GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 99-71-8
Chemical Name p-sec-Butylphenol
Substance ID 24A6080
Classification year (FY) FY2012
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised New
Classification result in other fiscal year  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition)
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Solid (GHS definition)
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Solid (GHS definition)
5 Gases under pressure Not applicable
-
-
- - Solid (GHS definition)
6 Flammable liquids Not applicable
-
-
- - Solid (GHS definition)
7 Flammable solids Classification not possible
-
-
- - No data available. Besides, there is information on a flash point of 116 deg C [closed-cup] (MSDS (Sigma-Aldrich) (2010)).
8 Self-reactive substances and mixtures Not applicable
-
-
- - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable
-
-
- - Solid (GHS definition)
10 Pyrophoric solids Classification not possible
-
-
- - No data available.
11 Self-heating substances and mixtures Classification not possible
-
-
- - Test methods applicable to solid (melting point <= 140 deg C) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- - Solid (GHS definition)
14 Oxidizing solids Not applicable
-
-
- - The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
15 Organic peroxides Not applicable
-
-
- - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Classification not possible
-
-
- - There is information that it is corrosive to steel, bronze, brass, copper, and compounds containing copper (Hommel (1996)), but the classification is not possible due to no data in a corrosion rate test.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Category 4


Warning
H302 P301+P312
P264
P270
P330
P501
It was classified in Category 4 based on an LD50 value of 1,650 mg/kg for rats (HPVIS (2009), corresponding to List 2).
1 Acute toxicity (Dermal) Classification not possible
-
-
- - No data available.
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible
-
-
- - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - No data available.
2 Skin corrosion/irritation Category 1


Danger
H314 P301+P330+P331
P303+P361+P353
P305+P351+P338
P304+P340
P260
P264
P280
P310
P321
P363
P405
P501
In a test by a 4-hour semi-occlusive application of 0.5 mL of the undiluted solution of this substance liquefied by heating to the rabbit skin (GLP-compliant), all six animals showed necrosis, PII (primary irritation index) was 7.25, and it was concluded to be corrosive (HPVIS (2009)). Therefore, it was classified in Category 1.
3 Serious eye damage/eye irritation Category 1


Danger
H318 P305+P351+P338
P280
P310
There are no data, but because it is corrosive to the skin (Category 1), it was classified in Category 1.
4 Respiratory sensitization Classification not possible
-
-
- - No data available.
4 Skin sensitization Classification not possible
-
-
- - No data available.
5 Germ cell mutagenicity Classification not possible
-
-
- - The classification is not possible due to no in vivo test data. Besides, as for in vitro tests, there is a report on a negative result in both an Ames test and a chromosomal aberration test with cultured Chinese hamster cells (JECDB (Access on Aug. 2012)).
6 Carcinogenicity Classification not possible
-
-
- - No data available.
7 Reproductive toxicity Classification not possible
-
-
- - No data available.
8 Specific target organ toxicity - Single exposure Category 2 (systemic toxicity)


Warning
H371 P308+P311
P260
P264
P270
P405
P501
Lethargy, bloody eye discharge, bloody nasal discharge, labored breathing, tachypnea, anorexia, decreased body weights, hunchback position, muscle twitching, and calm were observed in an acute oral toxicity test with rats (dose range: 1,000-3,000 mg/kg). The dead animals showed hemorrhage in the gastrointestinal tract, liver, and lung, distention of the stomach, and discoloration of the liver and kidney (HPVIS (2009)), and an LD50 value was 1,650 mg/kg/bw. Because the target organ could not be specified, it was classified in Category 2 (systemic toxicity).
9 Specific target organ toxicity - Repeated exposure Category 2 (kidney)


Warning
H373 P260
P314
P501
It was classified in Category 2 (kidney) because papillary necrosis of the kidney was observed at or above 300 mg/kg/day (converted guidance value: 93.3 mg/kg/day) corresponding to the guidance values for Category 2 at histological examination at the end of a treatment period in a 28-day repeated oral administration test with rats (Toxicity Test Guidelines specified by the Chemical Substances Control Law, GLP) (JECDB (Access on Aug. 2012)). In the test, hyperplasia of the mucosal epithelium in the forestomach in all males and females, and papillary necrosis of the kidney in three females and two males were found in the 1,000 mg/kg/day group (converted guidance value: 311 mg/kg/day), and there is a report on papillary necrosis of the kidney and hyperplasia of the mucosal epithelium in the forestomach in one male in the 300 mg/kg/day group. And effects on the upper gastrointestinal tract (including the stomach) and kidney were also seen at higher doses (500 mg/kg/day or above) in another test by diet administration to rats for 6-24 months (HPVIS (2009)). Besides, because this substance is corrosive to the skin, effects on the stomach were judged as local effects and were not adopted for classification.
10 Aspiration hazard Classification not possible
-
-
- - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 2
-
-
H401 P273
P501
It was classified in Category 2 from 96-hour LC50 = 2.6 mg/L for fish (Oryzias latipes) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2004)).
11 Hazardous to the aquatic environment (Long-term) Category 2


-
H411 P273
P391
P501
If chronic toxicity data are used, then it is classified in Category 2 due to being not rapidly degradable (not readily degradable, BOD 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law)), and 72-hour NOEC = 0.44 mg/L for algae (Pseudokirchneriella subcapitata) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2004)).
If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 2 due to being not rapidly degradable (not readily degradable, BOD 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1980)), and 96-hour LC50 = 2.6 mg/L for fish (Oryzias latipes) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2004)).
From the above results, it was classified in Category 2.
12 Hazardous to the ozone layer Classification not possible
-
-
- - This substance is not listed in the Annexes to the Montreal Protocol.


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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