Item | Information |
---|---|
CAS RN | 99-71-8 |
Chemical Name | p-sec-Butylphenol |
Substance ID | 24A6080 |
Classification year (FY) | FY2012 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | New |
Classification result in other fiscal year | |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Solid (GHS definition) |
5 | Gases under pressure | Not applicable |
- |
- | - | Solid (GHS definition) |
6 | Flammable liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
7 | Flammable solids | Classification not possible |
- |
- | - | No data available. Besides, there is information on a flash point of 116 deg C [closed-cup] (MSDS (Sigma-Aldrich) (2010)). |
8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
9 | Pyrophoric liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
10 | Pyrophoric solids | Classification not possible |
- |
- | - | No data available. |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to solid (melting point <= 140 deg C) substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
14 | Oxidizing solids | Not applicable |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. |
15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure. |
16 | Corrosive to metals | Classification not possible |
- |
- | - | There is information that it is corrosive to steel, bronze, brass, copper, and compounds containing copper (Hommel (1996)), but the classification is not possible due to no data in a corrosion rate test. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 |
P301+P312
P264 P270 P330 P501 |
It was classified in Category 4 based on an LD50 value of 1,650 mg/kg for rats (HPVIS (2009), corresponding to List 2). |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | No data available. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | No data available. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | No data available. |
2 | Skin corrosion/irritation | Category 1 |
Danger |
H314 |
P301+P330+P331
P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501 |
In a test by a 4-hour semi-occlusive application of 0.5 mL of the undiluted solution of this substance liquefied by heating to the rabbit skin (GLP-compliant), all six animals showed necrosis, PII (primary irritation index) was 7.25, and it was concluded to be corrosive (HPVIS (2009)). Therefore, it was classified in Category 1. |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 |
P305+P351+P338
P280 P310 |
There are no data, but because it is corrosive to the skin (Category 1), it was classified in Category 1. |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. |
4 | Skin sensitization | Classification not possible |
- |
- | - | No data available. |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | The classification is not possible due to no in vivo test data. Besides, as for in vitro tests, there is a report on a negative result in both an Ames test and a chromosomal aberration test with cultured Chinese hamster cells (JECDB (Access on Aug. 2012)). |
6 | Carcinogenicity | Classification not possible |
- |
- | - | No data available. |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | No data available. |
8 | Specific target organ toxicity - Single exposure | Category 2 (systemic toxicity) |
Warning |
H371 |
P308+P311
P260 P264 P270 P405 P501 |
Lethargy, bloody eye discharge, bloody nasal discharge, labored breathing, tachypnea, anorexia, decreased body weights, hunchback position, muscle twitching, and calm were observed in an acute oral toxicity test with rats (dose range: 1,000-3,000 mg/kg). The dead animals showed hemorrhage in the gastrointestinal tract, liver, and lung, distention of the stomach, and discoloration of the liver and kidney (HPVIS (2009)), and an LD50 value was 1,650 mg/kg/bw. Because the target organ could not be specified, it was classified in Category 2 (systemic toxicity). |
9 | Specific target organ toxicity - Repeated exposure | Category 2 (kidney) |
Warning |
H373 |
P260
P314 P501 |
It was classified in Category 2 (kidney) because papillary necrosis of the kidney was observed at or above 300 mg/kg/day (converted guidance value: 93.3 mg/kg/day) corresponding to the guidance values for Category 2 at histological examination at the end of a treatment period in a 28-day repeated oral administration test with rats (Toxicity Test Guidelines specified by the Chemical Substances Control Law, GLP) (JECDB (Access on Aug. 2012)). In the test, hyperplasia of the mucosal epithelium in the forestomach in all males and females, and papillary necrosis of the kidney in three females and two males were found in the 1,000 mg/kg/day group (converted guidance value: 311 mg/kg/day), and there is a report on papillary necrosis of the kidney and hyperplasia of the mucosal epithelium in the forestomach in one male in the 300 mg/kg/day group. And effects on the upper gastrointestinal tract (including the stomach) and kidney were also seen at higher doses (500 mg/kg/day or above) in another test by diet administration to rats for 6-24 months (HPVIS (2009)). Besides, because this substance is corrosive to the skin, effects on the stomach were judged as local effects and were not adopted for classification. |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 2 |
- |
H401 |
P273
P501 |
It was classified in Category 2 from 96-hour LC50 = 2.6 mg/L for fish (Oryzias latipes) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2004)). |
11 | Hazardous to the aquatic environment (Long-term) | Category 2 |
- |
H411 |
P273
P391 P501 |
If chronic toxicity data are used, then it is classified in Category 2 due to being not rapidly degradable (not readily degradable, BOD 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law)), and 72-hour NOEC = 0.44 mg/L for algae (Pseudokirchneriella subcapitata) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2004)). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 2 due to being not rapidly degradable (not readily degradable, BOD 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1980)), and 96-hour LC50 = 2.6 mg/L for fish (Oryzias latipes) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2004)). From the above results, it was classified in Category 2. |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. |
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