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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	92-88-6
Chemical Name	4,4'-Dihydroxydiphenyl
Substance ID	24A6070
Classification year (FY)	FY2012
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	New
Classification result in other fiscal year
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Solid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Solid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Solid (GHS definition)
6	Flammable liquids	Not applicable	- -	-	-	Solid (GHS definition)
7	Flammable solids	Classification not possible	- -	-	-	No data available.
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not applicable	- -	-	-	Solid (GHS definition)
10	Pyrophoric solids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of > 638 deg C (an acute oral toxicity test with rats for 4,4'-dihydroxydiphenyl, JECDB (Access on July 2012)).
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No data available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	- -	-	-	Solid (GHS definition)
14	Oxidizing solids	Not applicable	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure.
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Not classified	- -	-	-	It was classified as "Not classified" because there were no dead animals after administration of 2,000 mg/kg to rats (OECD TG423, GLP) (JECDB (Access on July 2012)), and an LD50 value was estimated to be > 2,000 mg/kg.
1	Acute toxicity (Dermal)	Category 4	Warning	H312	P302+P352 P362+P364 P280 P312 P321 P501	It was classified in Category 4 based on an LD50 value of 1,780 mg/kg for rabbits (RTECS (2003): the original article, Toxicology and Applied Pharmacology: 28, 313, 1974) after confirming the description in the original article.
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.
2	Skin corrosion/irritation	Classification not possible	- -	-	-	Data are lacking. Besides, it is described in the original article of List 3 information (RTECS (2003): the original article, Toxicology and Applied Pharmacology: 28, 313, 1974) that the degree of irritation was rated as 3 on a scale from 1 to 10 (maximum 10) in a test with rabbits, but the details are unknown.
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	Data are lacking. Besides, it is described in the original article of List 3 information (RTECS (2003): the original article, Toxicology and Applied Pharmacology: 28, 313, 1974) that the degree of irritation was rated as 3 on a scale from 1 to 10 (maximum 10) in a test with rabbits, but the details are unknown.
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.
4	Skin sensitization	Classification not possible	- -	-	-	No data available.
5	Germ cell mutagenicity	Category 2	Warning	H341	P308+P313 P201 P202 P280 P405 P501	It was reported to be positive in a micronucleus test with bone marrow after oral administration to mice (in vivo somatic cell mutagenicity test) (RTECS (2003): the original article, Mutation Research: 208, 61, 1988), and weak responses were observed at multiple sampling time points, although it is a finding with one dose of 40 mg/kg. Therefore, it was classified in Category 2. Besides, as for in vitro tests, it is reported that it was negative in an Ames test (JECDB (2004)), and positive in a chromosomal aberration test with CHL cells of Chinese hamsters (JECDB (2004)).
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.
7	Reproductive toxicity	Classification not possible	- -	-	-	In a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test with rats (OECD TG422, GLP), changes in urine such as turbidity of urine and a decrease in urine specific gravity were observed at the observation of general conditions, but no abnormalities from treatment with this substance were observed in delivery and lactation condition in addition to mating results such as estrus cycle, copulation index, fertility index, and the average number of estrus until copulation, and all pregnant animals delivered live newborns in the treated group like the control group. And the administration of this substance did not affect developmental parameters such as the number of corpus lutea, the number of implantations, implantation index, the number of newborns, delivery index, the number of live pups, live birth index, and viability index, and no abnormal morphology was seen in any newborn (JECDB (2004)). Therefore, there was no evidence of adverse effects on sexual function/fertility, but data are insufficient on effects on the development of offspring including teratogenicity. Therefore, it was classified as "Classification not possible."
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	It is reported that there were no dead animals after a single oral administration of 2,000 mg/kg bw, the upper limit of the guidance value range, to rats (OECD TG423, GLP), no adverse effects of the administration occurred in general status or body weights, and there were no abnormal findings at necropsy (JECDB (Access on July 2012)). Therefore, it corresponds to "Not classified" in oral administration. However, effects on the other routes (inhalation, dermal) are unknown due to no data. Therefore, it was classified as "Classification not possible" for specific target organ toxicity (single exposure).
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	In a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test with rats (OECD TG422, GLP), there were no deaths or slaughter in a moribund condition, no effects of the treatment were observed in general status, blood biochemical examination, necropsy, or histopathological examination, and the only changes were findings in urine; turbidity of urine and calcium oxalate-like crystal in urinary sediment occurred at or above 40 mg/kg/day (converted guidance value: about 20 mg/kg/day), and urine became cloudy with elapse of time after excretion at 200 mg/kg (converted guidance value: about 100 mg/kg/day) (JECDB (2004)). From the above, apparent treatment-related effects were only the changes in urine, and because no adverse effects were found at doses within the guidance value range (100 mg/kg/day or below), it corresponds to "Not classified" in the oral route. However, because effects in the other routes (inhalation, dermal) are unknown, it was classified as "Classification not possible" for specific target organ toxicity (repeated exposure).
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Category 2	- -	H401	P273 P501	It was classified in Category 2 from 48-hour EC50 = 1.8 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2003)).
11	Hazardous to the aquatic environment (Long-term)	Category 2	-	H411	P273 P391 P501	If chronic toxicity data are used, then it is classified in Category 2 due to being not rapidly degradable (not readily degradable, BOD 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 2002)), and 21-day NOEC = 0.11 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2003)). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 3 due to being not rapidly degradable (not readily degradable, BOD 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 2002)), and 96-hour LC50 = 13 mg/L for fish (Oryzias latipes) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2003)). By drawing a comparison between the above results, it was classified in Category 2.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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