NITE - Chemical Management Field

GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	88-53-9
Chemical Name	2-Amino-5-chloro-4-methylbenzenesulfonic acid
Substance ID	24A6066
Classification year (FY)	FY2012
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	New
Classification result in other fiscal year
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Solid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Solid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Solid (GHS definition)
6	Flammable liquids	Not applicable	- -	-	-	Solid (GHS definition)
7	Flammable solids	Classification not possible	- -	-	-	No data available.
8	Self-reactive substances and mixtures	Classification not possible	- -	-	-	There is a chemical group associated with self-reactive properties (haloanilines) in the molecule, but the classification is not possible due to no data.
9	Pyrophoric liquids	Not applicable	- -	-	-	Solid (GHS definition)
10	Pyrophoric solids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 360 deg C (IUCLID (2000)).
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No data available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	- -	-	-	Solid (GHS definition)
14	Oxidizing solids	Classification not possible	- -	-	-	The substance is an organic compound containing oxygen which is chemically bonded to the element other than carbon or hydrogen (sulfur). However, it was classified as "Classification not possible" due to no data.
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure.
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Not classified	- -	-	-	It was classified as "Not classified" because it is reported that there were no dead animals after administration of 2,000 mg/kg to rats (OECD Test Guideline 401; GLP-compliant), and an LD50 value was 2,000 mg/kg or above (JECDB (Access on July 2012)).
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	No data available.
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	It is reported that there were no deaths after 1-hour exposure to 10.7 mg/L in rats, and an LC50 value was > 10.7 mg/L/1 hour (converted 4-hour equivalent value: 2.675 mg/L/4 hours) (IUCLID (2000)). The result corresponds to Category 4 or "Not classified," but the category cannot be determined. Therefore, it was classified as "Classification not possible." Besides, it is described that the substance was in a dust state (IUCLID (2000)).
2	Skin corrosion/irritation	Not classified	- -	-	-	It was classified as "Not classified" in the Classification JIS (corresponding to Category 3 in UN GHS classification) because it was slightly irritating in a test by a 24-hour occlusive application of 500 mg to the rabbit skin (IUCLID (2000)).
3	Serious eye damage/eye irritation	Category 2A	Warning	H319	P305+P351+P338 P337+P313 P264 P280	Three tests with rabbits are described, and it is reported that it was moderately irritating, irritating, or not irritating (IUCLID (2000)). It was classified in Category 2A based on the results of being moderately irritating or irritating, corresponding to a more hazardous category. Besides, there is the information that a 2 g/L concentration (20 deg C) of this substance has pH 2-2.5 (IUCLID (2000)).
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.
4	Skin sensitization	Classification not possible	- -	-	-	No data available.
5	Germ cell mutagenicity	Not classified	- -	-	-	It was classified as "Not classified" based on a negative result in a micronucleus test by oral administration to mice (in vivo mutagenicity test) (IUCLID (2000)). Besides, as for in vitro tests, it is reported that it was negative in an Ames test (JECDB (Access on July 2012)), and a chromosomal aberration test with cultured Chinese hamster cells (CHL) gave a positive result, although the effects of a decrease in pH were suggested (JECDB (Access on July 2012)).
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.
7	Reproductive toxicity	Classification not possible	- -	-	-	No data available.
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	In a test by oral administration of 2,000 mg/kg to rats, transient diarrhea and loose stool were observed in both males and females, but no deaths were seen in males or females. No macroscopic abnormalities were found in males or females at pathological autopsy at the end of observation, and reduced weight gain was not observed in males or females (JECDB (Access on July 2012)). From the above, because there were no adverse effects at 2,000 mg/kg, the upper limit of the guidance value range, it corresponds to "Not classified" in the oral route. However, due to no data in the other routes, it was classified as "Classification not possible" for specific target organ toxicity (single exposure).
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	It is reported that in a 28-day repeated oral administration toxicity test with rats, no apparent effects of administration of the test substance were observed in any test item, and the NOEL was 1,000 mg/kg/day (converted guidance value: 311.1 mg/kg/day) above the guidance value range (JECDB (Access on July 2012)). Therefore, it corresponds to "Not classified" in oral administration. However, because effects in the other routes (inhalation, dermal) are unknown due to no data, it was classified as "Classification not possible" for specific target organ toxicity (repeated exposure).
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Not classified	- -	-	-	It was classified as "Not classified" from 96-hour LC50 = 6350 mg/L for fish (Danio rerio) (IUCLID, 2000).
11	Hazardous to the aquatic environment (Long-term)	Not classified	- -	-	-	Reliable chronic toxicity data were not obtained. It was classified as "Not classified" because it is not water-insoluble (water solubility = 2000 mg/L), and it was classified as "Not classified" in acute toxicity.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

To GHS Information