GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 88-18-6
Chemical Name 2-tert-Butylphenol
Substance ID 24A6065
Classification year (FY) FY2012
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised New
Classification result in other fiscal year  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition)
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Liquid (GHS definition)
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Liquid (GHS definition)
5 Gases under pressure Not applicable
-
-
- - Liquid (GHS definition)
6 Flammable liquids Category 4
-
Warning
H227 P370+P378
P403+P235
P210
P280
P501
It corresonds to Category 4 from a flash point of 80 deg C [closed-cup] (ICSC (J) (2004)) > 60 deg C and <= 93 deg C.
7 Flammable solids Not applicable
-
-
- - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable
-
-
- - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified
-
-
- - It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 335 deg C (ICSC (J) (2004)).
10 Pyrophoric solids Not applicable
-
-
- - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible
-
-
- - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- - The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable
-
-
- - Liquid (GHS definition)
15 Organic peroxides Not applicable
-
-
- - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Classification not possible
-
-
- - No data available. Besides, there is information that it attacks copper and its alloys (ICSC (J) (2004)).

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Category 4


Warning
H302 P301+P312
P264
P270
P330
P501
There is a report on LD50 values for rats of 1,231 mg/kg for males and 1,414 mg/kg for females (JECDB (2000)), and there is a report on 789 mg/kg as combined data for males and females (USEPA/HPV (2001), corresponding to List 1), and all of the above correspond to Category 4.
1 Acute toxicity (Dermal) Category 3


Danger
H311 P302+P352
P361+P364
P280
P312
P321
P405
P501
There is a report on LD50 values for rats of 1,373 mg/kg for males and 705 mg/kg for females (USEPA/HPV (2001)), and it corresponds to Category 4 for males and Category 3 for females. Therefore, it was classified in Category 3 by adopting a more hazardous category for females.
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible
-
-
- - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Category 4


Warning
H332 P304+P340
P261
P271
P312
It was classified in Category 4 based on an LC50 value of 1.07 mg/L/4 hours for rats (RTECS (2009): the original article, National Technical Information Service: OTS0558707). Besides, because the LC50 value (1.07 mg/L) was higher than the saturated vapour pressure concentration (0.0012 mg/L), a reference value of dust/mist was applied.
2 Skin corrosion/irritation Category 1


Danger
H314 P301+P330+P331
P303+P361+P353
P305+P351+P338
P304+P340
P260
P264
P280
P310
P321
P363
P405
P501
In a skin irritation test by a 4-hour semi-occlusive application of 0.5 mL of the undiluted test substance to six rabbits (OECD TG404; GLP-compliant), all animals showed necrosis at 1-7 days after the application, and the primary skin irritation index was 5.67 (ECETOC TR66 (1995)). Therefore, it was classified in Category 1. Besides, it is described that this substance is strongly irritating or caustic to the skin and eyes (BUA 231 (2001)).
3 Serious eye damage/eye irritation Category 1


Danger
H318 P305+P351+P338
P280
P310
It was classified in Category 1 because it is reported that there was severe irritation in a test in which 100 microL of this substance was applied to the rabbit eye, and this substance is corrosive to the skin. Besides, it is described that this substance is strongly irritating or caustic to the skin and eyes (BUA 231 (2001)).
4 Respiratory sensitization Classification not possible
-
-
- - No data available.
4 Skin sensitization Classification not possible
-
-
- - No data available.
5 Germ cell mutagenicity Not classified
-
-
- - It was classified as "Not classified" from a negative result in a micronucleus test with mouse bone marrow cells (in vivo somatic cell mutagenicity test) (BUA 231 (2001) Summary). Besides, as for in vitro tests, it is reported that it was negative in an Ames test (JECDB (2012), USEPA/HPV (2001)), and positive in a chromosomal aberration test with fibroblast cell line, CHL/IU derived from Chinese hamster lung (JECDB (2012)).
6 Carcinogenicity Classification not possible
-
-
- - No data available.
7 Reproductive toxicity Classification not possible
-
-
- - No data available.
8 Specific target organ toxicity - Single exposure Category 2 (central nervous system)


Warning
H371 P308+P311
P260
P264
P270
P405
P501
In a single-dose toxicity test by oral administration to rats (doses: 500, 1,000, 2,000 mg/kg), both dead and surviving animals showed a decrease in locomotor activity, ataxic gait, prone position, lateral position, and hypothermia on Day 1 and abnormal gait on Day 2, and tremor and lacrimation were also observed in dead animals (JECDB (2000)). Abnormal gait and lacrimation were also found at the highest dose in a 28-day repeated oral administration test with rats on this substance, and it is described that it was impossible to deny the possibility that these signs were attributed to central nervous system disorders (JECDB (2000)). Therefore, it was classified in Category 2 (central nervous system) based on the above symptoms observed in the single-dose toxicity test. Besides, there is a report on lesions in the stomach at necropsy and histological examination, but these were regarded as local effects due to oral administration of a corrosive/irritating substance and were not adopted for the rationale for classification.
9 Specific target organ toxicity - Repeated exposure Classification not possible
-
-
- - In a 28-day repeated dose toxicity test by oral administration to rats (doses: 0, 4, 20, 100, 500 mg/kg/day), ataxic gait at 500 mg/kg/day (converted guidance value: 156 mg/kg/day) above the guidance value range and transient salivation at or above 100 mg/kg/day (converted guidance value: 31 mg/kg/day) were observed, and higher values in relative liver weights were found at 500 mg/kg/day at the end of the treatment period, but no other changes related to the administration of the test substance were observed in body weights, food consumption, hematological examination, blood chemical examination, urine test, necropsy, or histopathological examination (JECDB (2000)), so it corresponds to "Not classified" in the oral route. However, effects in other routes are unknown due to no data, it was classified as "Classification not possible" for this hazard class.
10 Aspiration hazard Classification not possible
-
-
- - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 2
-
-
H401 P273
P501
It was classified in Category 2 from 72-hour EC50 = 1.3 mg/L for algae (Pseudokirchneriella subcapitata) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2010)).
11 Hazardous to the aquatic environment (Long-term) Category 1


Warning
H410 P273
P391
P501
If chronic toxicity data are used, then it is classified in Category 1 due to being not rapidly degradable (not readily degradable, BOD -3, -4, -4% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 2008)), and 72-hour NOEC = 0.098 mg/L for algae (Pseudokirchneriella subcapitata) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2010)).
If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 2 due to being not rapidly degradable (not readily degradable, BOD -3, -4, -4% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 2008)), 96-hour LC50 = 3.7 mg/L for fish (Oryzias latipes) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2010)), and 48-hour EC50 = 3.7 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2010)).
By drawing a comparison between the above results, it was classified in Category 1.
12 Hazardous to the ozone layer Classification not possible
-
-
- - This substance is not listed in the Annexes to the Montreal Protocol.


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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