Item | Information |
---|---|
CAS RN | 88-18-6 |
Chemical Name | 2-tert-Butylphenol |
Substance ID | 24A6065 |
Classification year (FY) | FY2012 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | New |
Classification result in other fiscal year | |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Liquid (GHS definition) |
5 | Gases under pressure | Not applicable |
- |
- | - | Liquid (GHS definition) |
6 | Flammable liquids | Category 4 |
Warning |
H227 |
P370+P378
P403+P235 P210 P280 P501 |
It corresonds to Category 4 from a flash point of 80 deg C [closed-cup] (ICSC (J) (2004)) > 60 deg C and <= 93 deg C. |
7 | Flammable solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 335 deg C (ICSC (J) (2004)). |
10 | Pyrophoric solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. |
14 | Oxidizing solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure. |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. Besides, there is information that it attacks copper and its alloys (ICSC (J) (2004)). |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 |
P301+P312
P264 P270 P330 P501 |
There is a report on LD50 values for rats of 1,231 mg/kg for males and 1,414 mg/kg for females (JECDB (2000)), and there is a report on 789 mg/kg as combined data for males and females (USEPA/HPV (2001), corresponding to List 1), and all of the above correspond to Category 4. |
1 | Acute toxicity (Dermal) | Category 3 |
Danger |
H311 |
P302+P352
P361+P364 P280 P312 P321 P405 P501 |
There is a report on LD50 values for rats of 1,373 mg/kg for males and 705 mg/kg for females (USEPA/HPV (2001)), and it corresponds to Category 4 for males and Category 3 for females. Therefore, it was classified in Category 3 by adopting a more hazardous category for females. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | No data available. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Category 4 |
Warning |
H332 |
P304+P340
P261 P271 P312 |
It was classified in Category 4 based on an LC50 value of 1.07 mg/L/4 hours for rats (RTECS (2009): the original article, National Technical Information Service: OTS0558707). Besides, because the LC50 value (1.07 mg/L) was higher than the saturated vapour pressure concentration (0.0012 mg/L), a reference value of dust/mist was applied. |
2 | Skin corrosion/irritation | Category 1 |
Danger |
H314 |
P301+P330+P331
P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501 |
In a skin irritation test by a 4-hour semi-occlusive application of 0.5 mL of the undiluted test substance to six rabbits (OECD TG404; GLP-compliant), all animals showed necrosis at 1-7 days after the application, and the primary skin irritation index was 5.67 (ECETOC TR66 (1995)). Therefore, it was classified in Category 1. Besides, it is described that this substance is strongly irritating or caustic to the skin and eyes (BUA 231 (2001)). |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 |
P305+P351+P338
P280 P310 |
It was classified in Category 1 because it is reported that there was severe irritation in a test in which 100 microL of this substance was applied to the rabbit eye, and this substance is corrosive to the skin. Besides, it is described that this substance is strongly irritating or caustic to the skin and eyes (BUA 231 (2001)). |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. |
4 | Skin sensitization | Classification not possible |
- |
- | - | No data available. |
5 | Germ cell mutagenicity | Not classified |
- |
- | - | It was classified as "Not classified" from a negative result in a micronucleus test with mouse bone marrow cells (in vivo somatic cell mutagenicity test) (BUA 231 (2001) Summary). Besides, as for in vitro tests, it is reported that it was negative in an Ames test (JECDB (2012), USEPA/HPV (2001)), and positive in a chromosomal aberration test with fibroblast cell line, CHL/IU derived from Chinese hamster lung (JECDB (2012)). |
6 | Carcinogenicity | Classification not possible |
- |
- | - | No data available. |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | No data available. |
8 | Specific target organ toxicity - Single exposure | Category 2 (central nervous system) |
Warning |
H371 |
P308+P311
P260 P264 P270 P405 P501 |
In a single-dose toxicity test by oral administration to rats (doses: 500, 1,000, 2,000 mg/kg), both dead and surviving animals showed a decrease in locomotor activity, ataxic gait, prone position, lateral position, and hypothermia on Day 1 and abnormal gait on Day 2, and tremor and lacrimation were also observed in dead animals (JECDB (2000)). Abnormal gait and lacrimation were also found at the highest dose in a 28-day repeated oral administration test with rats on this substance, and it is described that it was impossible to deny the possibility that these signs were attributed to central nervous system disorders (JECDB (2000)). Therefore, it was classified in Category 2 (central nervous system) based on the above symptoms observed in the single-dose toxicity test. Besides, there is a report on lesions in the stomach at necropsy and histological examination, but these were regarded as local effects due to oral administration of a corrosive/irritating substance and were not adopted for the rationale for classification. |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | In a 28-day repeated dose toxicity test by oral administration to rats (doses: 0, 4, 20, 100, 500 mg/kg/day), ataxic gait at 500 mg/kg/day (converted guidance value: 156 mg/kg/day) above the guidance value range and transient salivation at or above 100 mg/kg/day (converted guidance value: 31 mg/kg/day) were observed, and higher values in relative liver weights were found at 500 mg/kg/day at the end of the treatment period, but no other changes related to the administration of the test substance were observed in body weights, food consumption, hematological examination, blood chemical examination, urine test, necropsy, or histopathological examination (JECDB (2000)), so it corresponds to "Not classified" in the oral route. However, effects in other routes are unknown due to no data, it was classified as "Classification not possible" for this hazard class. |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 2 |
- |
H401 |
P273
P501 |
It was classified in Category 2 from 72-hour EC50 = 1.3 mg/L for algae (Pseudokirchneriella subcapitata) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2010)). |
11 | Hazardous to the aquatic environment (Long-term) | Category 1 |
Warning |
H410 |
P273
P391 P501 |
If chronic toxicity data are used, then it is classified in Category 1 due to being not rapidly degradable (not readily degradable, BOD -3, -4, -4% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 2008)), and 72-hour NOEC = 0.098 mg/L for algae (Pseudokirchneriella subcapitata) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2010)). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 2 due to being not rapidly degradable (not readily degradable, BOD -3, -4, -4% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 2008)), 96-hour LC50 = 3.7 mg/L for fish (Oryzias latipes) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2010)), and 48-hour EC50 = 3.7 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2010)). By drawing a comparison between the above results, it was classified in Category 1. |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. |
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