GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 87-59-2
Chemical Name 2,3-Dimethylaniline
Substance ID 24A6062
Classification year (FY) FY2012
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised New
Classification result in other fiscal year  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition)
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Liquid (GHS definition)
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Liquid (GHS definition)
5 Gases under pressure Not applicable
-
-
- - Liquid (GHS definition)
6 Flammable liquids Not classified
-
-
- - A flash point of 96 deg C [closed-cup] (ICSC (J) (2007)) is 93 deg C.
7 Flammable solids Not applicable
-
-
- - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable
-
-
- - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified
-
-
- - It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 545 deg C (ICSC (J) (2007)).
10 Pyrophoric solids Not applicable
-
-
- - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible
-
-
- - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- - Organic compounds containing no oxygen, fluorine or chlorine.
14 Oxidizing solids Not applicable
-
-
- - Liquid (GHS definition)
15 Organic peroxides Not applicable
-
-
- - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Classification not possible
-
-
- - No data available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Category 4


Warning
H302 P301+P312
P264
P270
P330
P501
It was classified in Category 4 based on LD50 values for rats of 930 mg/kg (Initial Risk Assessment Report 208 (NITE, CERI, NEDO, 2005)) and 933 mg/kg (Environmental Risk Assessment for Chemical Substances vol. 7 (Ministry of the Environment, 2009)).
1 Acute toxicity (Dermal) Category 3


Danger
H311 P302+P352
P361+P364
P280
P312
P321
P405
P501
It was classified in Category 3 based on an LD50 value of 500-1,000 mg/kg for guinea pigs (Initial Risk Assessment Report 208 (NITE, CERI, NEDO, 2005)).
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible
-
-
- - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - No data available.
2 Skin corrosion/irritation Category 2


Warning
H315 P302+P352
P332+P313
P362+P364
P264
P280
P321
It was classified in Category 2 because it is reported that severe irritation was observed in a 24-hour occlusive application test with guinea pigs (Hazard Assessment Report Ver. 1.0, No. 208 (CERI, NITE, 2005)), and it is described that this substance and its isomer mixture irritate the skin in humans and may cause erythema and pain on contact with the skin (Environmental Risk Assessment for Chemical Substances vol. 5 (Ministry of the Environment, 2006)).
3 Serious eye damage/eye irritation Classification not possible
-
-
- - Data are lacking. Besides, it is described that this substance and its isomer mixture may irritate the eye (Environmental Risk Assessment for Chemical Substances vol. 5 (Ministry of the Environment, 2006)), but no data are quoted, and the details are unknown.
4 Respiratory sensitization Classification not possible
-
-
- - No data available.
4 Skin sensitization Classification not possible
-
-
- - No data available.
5 Germ cell mutagenicity Classification not possible
-
-
- - Data are lacking. Besides, it was reported to be negative in a DNA synthesis inhibition test with the testis after oral administration to mice (in vivo germ cell genotoxicity test) (Environmental Risk Assessment for Chemical Substances vol. 7 (Ministry of the Environment, 2009)). And as for in vitro tests, Ames tests gave both positive (JECDB (Access on July 2012), NTP DB (Access on June 2012)) and negative results (Initial Risk Assessment Report 208 (NITE, CERI, NEDO, 2005)), and it was reported to be positive in a chromosomal aberration test with CHL/IU cells (JECDB (Access on July 2012)).
6 Carcinogenicity Classification not possible
-
-
- - No data available. Besides, ACGIH classified it in A3 for carcinogenicity as mixed isomers.
7 Reproductive toxicity Classification not possible
-
-
- - No data available.
8 Specific target organ toxicity - Single exposure Classification not possible
-
-
- - It is described that exposure at high levels of this substance could cause lowering of consciousness and formation of methemoglobin (Environmental Risk Assessment for Chemical Substances vol. 7 (Ministry of the Environment, 2009)), but no specific data are quoted, and the details are unknown. Therefore, the classification is not possible due to lack of data. Besides, as data on 3,5-dimethylaniline, the isomer, it is reported that in an oral administration test with rats, blood methemoglobin level exceeded 5% after administration of 145 mg/kg or above (the control group, 4.96%) and reached the maximum of 32.7% at 3 hours after administration of 580 mg/kg (Environmental Risk Assessment for Chemical Substances vol. 7 (Ministry of the Environment, 2009)), and effects on the blood were observed.
9 Specific target organ toxicity - Repeated exposure Category 2 (blood, kidney, liver)


Warning
H373 P260
P314
P501
In a 28-day repeated dose toxicity test by oral administration to rats (Guidelines specified by the Chemical Substances Control Law, GLP), decreases in hemoglobin level, erythrocyte count, and hematocrit value and increased methemoglobin were observed at or above 60 mg/kg (converted guidance value: 18.7 mg/kg/day) corresponding to the guidance value range for Category 2, histopathological examination revealed increased deposits of hemosiderin in the spleen and increased hematopoiesis in the bone marrow, and these were considered to be increased hematopoiesis to compensate for anemia with methemoglobinemia (JECDB (Access on July 2012)). Therefore, it was classified in Category 2 (blood). And at 300 mg/kg (converted guidance value: 93.3 mg/kg/day) corresponding to the guidance value range for Category 2, an increase in urinary protein, increases in erythrocytes and leukocytes and an increase in small round epithelial cells in urinary sediment, and an increase in urea nitrogen were found, and histopathological examination showed basophilic changes in the renal tubules and mineralization of the inner medulla, increased incidence of eosinophilic bodies in the renal tubular epithelium in addition to papillary necrosis, dilatation of the renal tubules, and cellular infiltration in the cortical interstitium (JECDB (Access on July 2012)). Therefore, it was classified in Category 2 (kidney). Furthermore, it was classified in Category 2 (liver) because increases in activities of gamma-GTP and GPT, an increase in total cholesterol, hypertrophy of centrilobular hepatocytes, and bile duct proliferation at the histopathological examination were seen at 300 mg/kg, and these were considered to be slight hepatic disorders (JECDB (Access on July 2012)).
10 Aspiration hazard Classification not possible
-
-
- - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 2
-
-
H401 P273
P501
It was classified in Category 2 from 48-hour EC50 = 8.9 mg/L for crustacea (Daphnia magna) (Environmental Risk Assessment for Chemical Substances Vol. 7 (Ministry of the Environment, 2009); Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2003); ECETOC TR91, 2003).
11 Hazardous to the aquatic environment (Long-term) Category 1


Warning
H410 P273
P391
P501
If chronic toxicity data are used, it was classified in Category 1 due to being not rapidly degradable (BOD: 3% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1990)), and 21-day NOEC = 0.1 mg/L for crustacea (Daphnia magna) (Environmental Risk Assessment for Chemical Substances Vol. 7 (Ministry of the Environment, 2009); Hazard Assessment Report (CERI, NITE, 2005)).
12 Hazardous to the ozone layer Classification not possible
-
-
- - This substance is not listed in the Annexes to the Montreal Protocol.


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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