NITE - Chemical Management Field

GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	86-74-8
Chemical Name	Carbazole
Substance ID	24A6061
Classification year (FY)	FY2012
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	New
Classification result in other fiscal year
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Solid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Solid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Solid (GHS definition)
6	Flammable liquids	Not applicable	- -	-	-	Solid (GHS definition)
7	Flammable solids	Classification not possible	- -	-	-	It is combustible from a flash point of 220 deg C (MSDS (Sigma-Aldrich) (Access on July 2012)), but the classification is not possible due to no data in the prescribed test.
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not applicable	- -	-	-	Solid (GHS definition)
10	Pyrophoric solids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 540 deg C (NITE Chemical Risk Information Platform (NITE-CHRIP) (Access on July 2012)) (original reference: ACROS-web (ACROS-MSDS)).
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No data available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	- -	-	-	Solid (GHS definition)
14	Oxidizing solids	Not applicable	- -	-	-	Organic compounds containing no oxygen, fluorine or chlorine.
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure.
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Not classified	- -	-	-	It was classified as "Not classified" based on an LD50 value of > 5,000 mg/kg for rats (IARC 32 (1983)).
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	No data available.
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.
2	Skin corrosion/irritation	Classification not possible	- -	-	-	It is reported that it was not irritating in a test in which a 10% suspension of this substance in 0.5% carboxymethylcellulose was applied to the rabbit skin (Draize Test) (IUCLID (2000)), but it was insufficient because exposure time and application amount are unknown, and the application concentration (10%) was low. Therefore, it was classified as "Classification not possible" due to lack of data.
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	It is reported that it was not irritating in an eye irritation test with rabbits (Draize Test) (IUCLID (2000)), but application amount and application concentration are unknown. Therefore, it was classified as "Classification not possible" due to lack of data.
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.
4	Skin sensitization	Classification not possible	- -	-	-	No data available.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	The classification is not possible due to no in vivo test data. Besides, as for in vitro tests, there is a report on a negative result in an Ames test (IARC 32 (1983), NTP DB (1990)).
6	Carcinogenicity	Category 2	Warning	H351	P308+P313 P201 P202 P280 P405 P501	It was classified in Category 2 because IARC classified it in Group 2B for carcinogenicity (Agents Classified by the IARC Monographs, Volumes 1–105 (2012)). Besides, in a 96-week diet administration test with mice, in the treated groups, there is a report on significant increases in the incidences of neoplastic nodules and hepatocellular carcinoma in the liver, the occurrence of papilloma in the forestomach, which was not observed in the control group, and a significant increase in the incidence of squamous cell carcinoma (in the high dose group) (IARC 32 (1983)).
7	Reproductive toxicity	Classification not possible	- -	-	-	In a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test by oral administration to rats (OECD TG422, GLP), in the groups of 200 and 1,000 mg/kg, there were lower values in body weights or weight gain in males and females, no treatment-related effects were observed in reproductive parameters such as copulation index, fertility index, and delivery index in parent animals, and no treatment-related changes were found in parameters of the development of offspring such as the number of pups born, the number of live pups born, live birth index, and viability index on day 4 of lactation (Safety Test (Ministry of Economy, Trade and Industry (METI, 2009)), corresponding to List 2). Therefore, it was judged that there were no adverse effects on sexual function and fertility, but data on effects on the development of offspring including teratogenicity are insufficient. Therefore, it was classified as "Classification not possible."
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	No data available.
9	Specific target organ toxicity - Repeated exposure	Category 2 (liver)	Warning	H373	P260 P314 P501	In a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test by oral administration to rats (OECD TG422, GLP), lower values in albumin and total protein in females in the groups of 200 and 1,000 mg/kg, and higher values in ALT and lower values in blood glucose in males in the 1,000 mg/kg group were observed, and as for organ weights, higher values in relative liver weights in males in the groups of 200 and 1,000 mg/kg, and higher values in relative kidney weights in males in the 1,000 mg/kg group were found. Histopathological examination revealed centrilobular hepatocellular hypertrophy of the liver in males in the groups of 200 and 1,000 mg/kg, tubular dilatation and regeneration epithelium in the kidney in males and females in the 1,000 mg/kg group, and increased hyaline droplets in the proximal tubules in males in the 1,000 mg/kg group (Safety Test (Ministry of Economy, Trade and Industry (METI, 2009))). From the above, toxicity was seen in the liver and kidney as a result of repeated administration, and kidney toxicity was at 1,000 mg/kg/day (converted guidance value: 467 mg/kg) above the guidance value range. However, because liver toxicity was observed at or above 200 mg/kg/day (converted guidance value: 93 mg/kg) corresponding to the guidance values for Category 2, it was classified in Category 2 (liver).
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Not classified	- -	-	-	It was classified as "Not classified" because acute toxicity is not reported for algae, crustacea, and fish at concentrations close to water solubility (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2003)).
11	Hazardous to the aquatic environment (Long-term)	Category 1	Warning	H410	P273 P391 P501	If chronic toxicity data are used, then it is classified in Category 1 due to being not rapidly degradable (BOD 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1977)), and 72-hour NOEC = 0.067 mg/L for algae (Pseudokirchneriella subcapitata) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2008)). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified as "Not classified" because it is not rapidly degradable (BOD 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1977)), and acute toxicity is not reported for algae, crustacea, and fish at concentrations close to water solubility (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2003)). By drawing a comparison between the above results, it was classified in Category 1.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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