NITE - Chemical Management Field

GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	54839-24-6
Chemical Name	Propylene glycol monoethyl ether acetate
Substance ID	24A6050
Classification year (FY)	FY2012
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	New
Classification result in other fiscal year
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Liquid (GHS definition)
6	Flammable liquids	Category 3	Warning	H226	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	It corresponds to Category 3 from a flash point of 53 deg C [closed-cup] (ICSC (2004)) >= 23 deg C and <= 60 deg C.
7	Flammable solids	Not applicable	- -	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 325 deg C (ICSC (2004)).
10	Pyrophoric solids	Not applicable	- -	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14	Oxidizing solids	Not applicable	- -	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure.
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Not classified	- -	-	-	It was classified as "Not classified" because it is reported that administration of 5 mL/kg bw to rats caused no death, and an LD50 value was > 5 mL/kg bw (4,700 mg/kg bw) (ECETOC TR95 vol. II (2005)).
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	No data available.
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Liquid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	There is a report on an LC50 value of > 6.99 mg/L/4 hours (1150 ppm) for rats (ECETOC TR95 vol. II (2005)), but because the category cannot be determined, the classification is not possible. Besides, because the exposure concentration was lower than 90% of the saturated vapour pressure concentration (12.27 mg/L), a reference value of gas was applied as a vapour with little mist.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.
2	Skin corrosion/irritation	Not classified	- -	-	-	It is reported that it had a low potential of irritancy in a test with rabbits (OECD TG404, GLP) (ECETOC TR95 vol. II (2005)). And it is described that the test results showed slight erythema in two out of three animals and slight edema in one, but it could not be evidence to classify this substance as an irritant (IUCLID (2000)). Therefore, it was classified as "Not classified" in the Classification JIS (corresponding to Category 3 in UN GHS classification).
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	In a test with rabbits (OECD TG405, GLP), there was hyperemia of the conjunctiva initially and slight irritation, but the symptoms disappeared by day 2, and there were no effects on the cornea or iris (ECETOC TR95 vol. II (2005)). And in another report of the test, it is described that the mean scores, parameters per site, were not high enough to classify it in R36 of the EU Risk Phrase, but positive responses were seen in all three animals, and as a result, it was judged as slightly irritating (IUCLID (2000)). Therefore, it was classified in Category 2B.
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.
4	Skin sensitization	Classification not possible	- -	-	-	It is reported that there was no evidence of delayed contact hypersensitivity in a maximization test guinea pigs (GLP-compliant) (ECETOC TR95 vol. II (2005)), and it was not sensitizing (IUCLID (2000)), but it is List 2 data, and the positive rate is unknown. Therefore, it was classified as "Classification not possible."
5	Germ cell mutagenicity	Classification not possible	- -	-	-	The classification is not possible due to no in vivo test data. Besides, as for in vitro tests, it is reported that it was negative in both an Ames test and a chromosomal aberration test with CHO cells of Chinese hamsters (ECETOC TR95 vol. II (2005)).
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.
7	Reproductive toxicity	Classification not possible	- -	-	-	No data available.
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	After oral administration of 4700 mg/kg far above the guidance value range to rats, non-specific signs of lethargy, salivation, and pallor of the extremities were observed, and all the animals returned to normal by day 4 (ECETOC TR95 vol. II (2005)). Therefore, it corresponds to "Not classified" in the oral route. On the other hand, as for inhalation administration, 4-hour exposure to 6.99 mg/L (vapour) caused no death, and the only effects were irritation of the eye and nose (ECETOC TR95 vol. II (2005)), but effects at the upper limit of the guidance value range (20 mg/L) are unknown due to no data, so the classification is not possible. Furthermore, because of no data on dermal administration, it was classified as "Classification not possible" for specific target organ toxicity (single exposure).
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	In a 28-day repeated inhalation exposure test with rats (vapour: 6 hours/day, 5 days/week: OECD TG412, GLP), the only effect was a reduced response to external stimuli observed at or above 292 ppm (converted guidance value: 0.551 mg/L), but there was no evidence of toxicity at necropsy and histopathological examination at the end of the test, and no adverse effects were shown even at 1,176 ppm (converted guidance value: 2.24 mg/L) above the guidance value range (ECETOC TR95 vol. II (2005)). Therefore, it corresponds to "Not classified" in the inhalation route, but effects in the other routes (oral, dermal) are unknown due to no data, so it was classified as "Classification not possible" for specific target organ toxicity (repeated exposure).
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Not classified	- -	-	-	It was classified as "Not classified" because toxicity values are > 100 mg/L for both crustacea and fish (IUCLID, 2000).
11	Hazardous to the aquatic environment (Long-term)	Not classified	- -	-	-	Reliable chronic toxicity data were not obtained. It was classified as "Not classified" because it is not water-insoluble (water solubility: 95000 mg/L, NITE, 2012), and it corresponds to "Not classified" in acute toxicity for crustacea and fish (IUCLID, 2000).
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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