GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 17689-77-9
Chemical Name Ethyltriacetoxysilane
Substance ID 24A6046
Classification year (FY) FY2012
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised New
Classification result in other fiscal year  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition)
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Liquid (GHS definition)
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Liquid (GHS definition)
5 Gases under pressure Not applicable
-
-
- - Liquid (GHS definition)
6 Flammable liquids Classification not possible
-
-
- - There are data on a flash point: 104 deg C (open-cup) (SIDS (2005)), but no data in the prescribed closed-cup test method, therefore the classification is not possible.
7 Flammable solids Not applicable
-
-
- - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable
-
-
- - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Classification not possible
-
-
- - No data available.
10 Pyrophoric solids Not applicable
-
-
- - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible
-
-
- - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified
-
-
- - It contains a metalloid (Si), but from data on water solubility: 41.6 g/L (SIDS (2005)), it is estimated that it does not react vigorously with water.
13 Oxidizing liquids Classification not possible
-
-
- - The substance is an organic compound containing oxygen which is chemically bonded to the element other than carbon or hydrogen (Si). However, the classification is not possible due to no data on oxidization.
14 Oxidizing solids Not applicable
-
-
- - Liquid (GHS definition)
15 Organic peroxides Not applicable
-
-
- - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Classification not possible
-
-
- - No data available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Category 4


Warning
H302 P301+P312
P264
P270
P330
P501
It was classified in Category 4 based on an LD50 value of 1,462 mg/kg for rats [OECD TG401; GLP] (SIDS (2005)).
1 Acute toxicity (Dermal) Classification not possible
-
-
- - No data available. Besides, for acetic acid, the related substance, there is a report on an LD50 value of 1,060 mg/kg for rabbits (SIDS (2005)), corresponding to Category 4.
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible
-
-
- - No data available. Besides, for acetic acid, the related substance, there is a report on an LC50 value by 4-hour exposure for rats of 11.4 mg/L (4,641 ppm), corresponding to Category 4 (regardless of whether mist was mixed or not).
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - No data available.
2 Skin corrosion/irritation Category 1


Danger
H314 P301+P330+P331
P303+P361+P353
P305+P351+P338
P304+P340
P260
P264
P280
P310
P321
P363
P405
P501
In a test by a 3-minute semi-occlusive application of 0.5 mL of undiluted this substance to the rabbit skin, severe lesions were observed 72 hours after the application in four out of six animals, and reversibility was slight during a 14-day observation period. And the primary dermal irritation index (PDII) was 4.28, and it was judged as corrosive (SIDS (2005)). Therefore, it was classified in Category 1.
3 Serious eye damage/eye irritation Category 1


Danger
H318 P305+P351+P338
P280
P310
It was classified in Category 1 because it was classified as a corrosive substance in skin corrosion/irritation.
4 Respiratory sensitization Classification not possible
-
-
- - No data available.
4 Skin sensitization Classification not possible
-
-
- - No data available.
5 Germ cell mutagenicity Classification not possible
-
-
- - The classification is not possible due to no in vivo test data. Besides, as for in vitro mutagenicity tests, it was reported to be negative in an Ames test (SIDS (2005)).
6 Carcinogenicity Classification not possible
-
-
- - No data available.
7 Reproductive toxicity Classification not possible
-
-
- - No data available.
8 Specific target organ toxicity - Single exposure Category 2 (systemic toxicity)


Warning
H371 P308+P311
P260
P264
P270
P405
P501
In an acute oral toxicity test with rats (OECD TG401, GLP-compliant), deaths occurred at or above 1500 mg/kg corresponding to the guidance values for Category 2, and symptoms such as decreased activity, lethargy, lacrimation, salivation, irregular gait, hunched posture, and labored respiration are reported (SIDS (2005)), but the target organ cannot be specified. Therefore, it was classified in Category 2 (systemic toxicity). Besides, as remarkable findings at necropsy, discoloration, adhesions, and thickening of the mucous membranes in the stomach/gastrointestinal tract were dose-dependently observed (SIDS (2005)), but it was not adopted for the rationale for classification because the above findings in the gastrointestinal tract were regarded as local effects by oral administration of a corrosive substance (this substance was classified as a corrosive substance for the skin and eye).
9 Specific target organ toxicity - Repeated exposure Classification not possible
-
-
- - Data are lacking. Besides, after 7-day repeated oral administration to rats, gastrointestinal tract injury characterized by ulceration of the esophagus and stomach was observed at or above 100 mg/kg/day (SIDS (2005)), but all these effects were regarded as local effects due to irritation of acetic acid, which was produced by hydrolysis of this substance. And it is described that in a test by inhalation exposure to acetic acid for 3-35 days in rats and mice, decreased activity, behavioral changes, and reduced work capacity at or above 15 ppm, and decreased growth, increased kidney weights, and signs of kidney damage at 23-31 ppm were found (SIDS (2005)), but the details are unknown.
10 Aspiration hazard Classification not possible
-
-
- - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Not classified
-
-
- - it was classified as "Not classified" from 48-hour EC50 = 6000 mg/L for crustacea (Daphnia magna) for acetic acid (pH adjustment), the hydrolysis product (SIDS, 2006).
11 Hazardous to the aquatic environment (Long-term) Not classified
-
-
- - Reliable chronic toxicity data were not obtained. As for acetic acid, the hydrolysis product, it is not water-insoluble (water solubility: 243000 mg/L, PHYSPROP Database, 2009), and it corresponds to "Not classified" in acute toxicity for crustacea (SIDS, 2006), therefore the substance was classified as "Not classified."
12 Hazardous to the ozone layer Classification not possible
-
-
- - This substance is not listed in the Annexes to the Montreal Protocol.


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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