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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	4454-05-1
Chemical Name	3,4-Dihydro-2-methoxy-2H-pyran
Substance ID	24A6044
Classification year (FY)	FY2012
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	New
Classification result in other fiscal year
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Liquid (GHS definition)
6	Flammable liquids	Category 2	Danger	H225	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	It corresponds to Category 2 from a flash point of 16 deg C [unknown] (Lange (16th, 2005)) < 23 deg C and an initial boiling point of 128 deg C (CRC (91st, 2010)) > 35 deg C. Besides, there are data of 22.8 deg C [closed-cup] (SIDS (2003)).
7	Flammable solids	Not applicable	- -	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 210 deg C (SIDS (2003)).
10	Pyrophoric solids	Not applicable	- -	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14	Oxidizing solids	Not applicable	- -	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure.
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	Among LD50 values for rats described in an assessment document (SIDS (2003)), two with higher reliability by SIDS (1,640 mg/kg bw and 3,740 mg/kg bw) were adopted for classification. Among them, one corresponds to Category 4, and the other corresponds to "Not classified." From a safety point of view, the category with higher hazard was adopted, and it was classified in Category 4.
1	Acute toxicity (Dermal)	Not classified	- -	-	-	It was classified as "Not classified" in the Classification JIS (corresponding to Category 5 in UN GHS classification) based on the one with higher reliability (4,920 mg/kg bw) among LD50 values for rabbits described in an assessment document (SIDS (2003)).
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Liquid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Category 4	Warning	H332	P304+P340 P261 P271 P312	It was classified in Category 4 based on an LC50 value by 1-hour exposure for rats of 40.8-43.0 mg/L (converted 4-hour equivalent value: 4,307-4,538 ppm) (SIDS (2003)). Besides, because the toxicity value (40.8-43.0 mg/L) was lower than 90% of the saturated vapour pressure concentration (77 mg/L), a reference value of gasses was applied. Besides, there is a report on an LC50 value by 4-hour exposure for rats of > 6.1 mg/L (> 1,310 ppm) (SIDS (2003)), but the category cannot be determined with the data.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	In a test by a 4-hour occlusive application of 0.5 mL of the undiluted test substance to the skin of six rabbits, the average scores at 24, 48, 72 hours after removal of the patch were 2.0, 2.5, 2.5 for erythema and 3.3, 2.7, 2.3 for edema (SID (2003)). Because the average scores for edema were >= 2.3 and <= 4.0 on three consecutive days, it was classified in Category 2.
3	Serious eye damage/eye irritation	Not classified	- -	-	-	In a test in which 0.1 mL of undiluted this substance was applied to the conjunctival sac of rabbits (OECD TG405), mild to moderate conjunctivitis occurred 1 hour after the application, the average scores after 24, 48, 72 hours were 1.0, 0.8, 0.2 for conjunctival redness, 0.3, 0, 0 for chemosis, and all 0 for cornea and iris (SIDS (2003)). From the above, because all the average scores for three days were less than 1 for the conjunctiva, iris, and cornea, it was classified as "Not classified."
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.
4	Skin sensitization	Classification not possible	- -	-	-	Data are lacking. Besides, it is described that it was not sensitizing in a sensitization test with guinea pigs (Epicutaneous test) (IUCLID (2000)), but the test details are unknown.
5	Germ cell mutagenicity	Not classified	- -	-	-	It was classified as "Not classified" based on negative results in micronucleus tests with bone marrow cells after oral or inhalation exposure in mice (in vivo somatic cell mutagenicity test) (OECD TG474, GLP) (SIDS (2003)). Besides, as for in vitro tests, it is reported that it was positive in an Ames test, and an HGPRT test with cultured cells of Chinese hamsters was negative in CHO cells and positive in V79 cells (SIDS (2003)).
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.
7	Reproductive toxicity	Classification not possible	- -	-	-	No data available.
8	Specific target organ toxicity - Single exposure	Category 2 (nervous system), Category 3 (narcotic effects, respiratory tract irritation)	Warning	H371 H336 H335	P308+P311 P260 P264 P270 P405 P501 P304+P340 P403+P233 P261 P271 P312	Sluggishness, prostration, moribund appearance, lacrimation, unsteady gait, and tremors were observed in the groups of 1,000 mg/kg or above in an acute oral toxicity test with rats (LD50: 1,640 mg/kg) (SIDS (2003)), and apathy, ataxia, and closed eyes in the 1,000 mg/kg dose group, and apathy, ataxia, prostration, reduced or no reflexes, and labored breathing in the groups of 2,150 mg/kg or above were found in another acute oral toxicity test with rats (LD50 value: 3740 mg/kg) (SIDS (2003)). From the above, after oral administration to rats, neurobehavioral symptoms were seen at 1,000 mg/kg corresponding to the guidance value range for Category 2, and narcosis-like actions such as apathy and reduced reflexes were observed in the groups of 2,150 mg/kg or above. Therefore, it was classified in Category 2 (nervous system), Category 3 (narcotic effects). And it was classified in Category 3 (respiratory tract irritation) because it is described that there were no deaths in an inhalation test by exposure to vapour in rats (dose: 6.1 mg/L/4 hours), but irritation to the respiratory tract was found (SIDS (2003)).
9	Specific target organ toxicity - Repeated exposure	Category 1 (respiratory tract)	Danger	H372	P260 P264 P270 P314 P501	In a 2-week repeated inhalation exposure test with rats (vapour: 6 hours/day, total 9-time exposure) (GLP-compliant), findings were edema in the nasal cavity and squamous metaplasia in the respiratory mucosa in the low dose group (480 mg/m3, converted guidance value: 0.075 mg/L), mild to moderate rhinitis, cell degeneration or atrophy of the olfactory epithelium, squamous metaplasia in the epithelium of the nasal cavity and to a lesser degree in the larynx and trachea in the middle dose group (4,660 mg/m3, converted guidance value: 0.725 mg/L), and signs of respiratory distress, respiratory tract injury by histological examination, and deaths of all animals (30/30) in the high dose group (20,640 mg/m3, converted guidance value: 3.21 mg/L) (SIDS (2003)). From the above, because adverse effects on the respiratory tract were observed at or above the low dose (480 mg/m3, converted guidance value: 0.075 mg/L) corresponding to the guidance values for Category 1, it was classified in Category 1 (respiratory tract).
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Not classified	- -	-	-	It was classified as "Not classified" because toxicity values are > 100 mg/L for all of the algae, crustacea, and fish (SIDS, 2005).
11	Hazardous to the aquatic environment (Long-term)	Not classified	- -	-	-	Reliable chronic toxicity data were not obtained. It was classified as "Not classified" because it is not water-insoluble (water solubility: 18800 mg/L, PHYSPROP Database (2009)), and it corresponds to "Not classified" in acute toxicity for algae, crustacea, and fish (SIDS, 2005).
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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