Item | Information |
---|---|
CAS RN | 2431-50-7 |
Chemical Name | 2,3,4-Trichloro-1-butene |
Substance ID | 24A6042 |
Classification year (FY) | FY2012 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | New |
Classification result in other fiscal year | |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Liquid (GHS definition) |
5 | Gases under pressure | Not applicable |
- |
- | - | Liquid (GHS definition) |
6 | Flammable liquids | Category 4 |
Warning |
H227 |
P370+P378
P403+P235 P210 P280 P501 |
It corresponds to Category 4 from a flash point of 63 deg C [closed-cup] (ICSC (2004)) > 60 deg C and <= 93 deg C. |
7 | Flammable solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
8 | Self-reactive substances and mixtures | Classification not possible |
- |
- | - | There is a chemical group associated with self-reactive properties (unsaturated bond) in the molecule, and there is information that explosive reactions may occur when there is a sudden thermal action (Hommel (1996)). Therefore, it may be applicable to the hazards of the higher precedence than Type G, but the classification is not possible due to no data. |
9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 530 deg C (GESTIS (Access on June 2012)). |
10 | Pyrophoric solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable |
- |
- | - | The substance is an organic compound containing chlorine (but not fluorine or oxygen) which is chemically bonded only to carbon or hydrogen. |
14 | Oxidizing solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure. |
16 | Corrosive to metals | Classification not possible |
- |
- | - | It is described that steel and aluminum are unsuitable as a container (GESTIS (Access on June. 2012)), but the classification is not possible due to no test data on the corrosion rate. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 |
P301+P312
P264 P270 P330 P501 |
It was classified in Category 4 based on LD50 values for rats of 341 mg/kg (Environmental Risk Assessment for Chemical Substances vol. 9 (Ministry of the Environment, 2011)) and 351 mg/kg (SIDS (Access on June 2012)). Besides, it was classified in Xn; R22 in EU classification (EC-JRC (ESIS) (Access on June 2012)). |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | No data available. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Category 2 |
Danger |
H330 |
P304+P340
P403+P233 P260 P271 P284 P310 P320 P405 P501 |
It was classified in Category 2 because a report on an LC50 value by 4-hour exposure of > 1.722 mg/L (264 ppm) for rats (SIDS (Access on June 2012)) corresponds to Category 2 or a less hazardous category, and it was classified in T; R23 in EU classification (EC-JRC (ESIS) (Access on June 2012)). Besides, because the test concentration was lower than 90% of the saturated vapour pressure concentration (15.0 mg/L), a reference value of gas was applied. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | No data available. |
2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 |
P302+P352
P332+P313 P362+P364 P264 P280 P321 |
It was classified in Category 2 because irritation was observed in a test in humans (SIDS (Access on June 2012)), and it was classified in Xi; R36/37/38 in EU classification (EC-JRC (ESIS) (Access on June 2012)). |
3 | Serious eye damage/eye irritation | Category 2 |
Warning |
H319 |
P305+P351+P338
P337+P313 P264 P280 |
It was classified in Category 2 because it is described that contact with vapour causes eye irritation and lacrimation in humans (SIDS (Access on June 2012)), and it was classified in Xi; R36/37/38 in EU classification (EC-JRC (ESIS) (Access on June 2012)). |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. |
4 | Skin sensitization | Classification not possible |
- |
- | - | No data available. |
5 | Germ cell mutagenicity | Not classified |
- |
- | - | It was classified as "Not classified" based on a negative result in a dominant lethal test by 5-day inhalation exposure in rats (in vivo heritable germ cell mutagenicity test) (IUCLID (2000), SIDS (Access on June 2012)). Besides, as for in vitro tests, it was reported to be positive in an Ames test (SIDS (Access on June 2012)). |
6 | Carcinogenicity | Category 2 |
Warning |
H351 |
P308+P313
P201 P202 P280 P405 P501 |
It is reported that in a 25-month inhalation exposure test with rats, out of 110 animals in the high dose group (after 12-week exposure to 2 ppm/6 hours, the dose was changed to 1.5 ppm//6 hours), 27% of males and 18% of females developed nasal neuroepithelioma and 3% of males developed malignant nasal neurinoma (SIDS (Access on June 2012)). This substance was classified in Category 2 because it was classified in Category 2 by Deutsche Forschungsgemeinschaft (MAK/BAT (2011)) and Carc. Cat. 3; R40 by the EU (EC-JRC (ESIS) (Access on June 2012)), and it was taken into account that nasal neuroepithelioma was an extremely rare and highly malignant tumor. |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | In a developmental toxicity test by inhalation exposure in pregnant rats during the organogenesis period, reduced weight gain was observed in maternal animals in the high dose group, but there were no malformations in fetuses (Environmental Risk Assessment for Chemical Substances vol. 9 (Ministry of the Environment, 2011)). And as a result of 5-day inhalation exposure in male rats to investigate fertility, decreases in food consumption and body weight were found during inhalation, but there were no adverse effects on gestation index, the number of implantations, postimplantation loss, etc. after mating with females (IUCLID (2000)). From the above reports, no adverse effects on sexual function/fertility and the development of offspring were seen, but exposure effects on sexual function/fertility were obtained only in males, and there were no female data. Therefore, it was classified as "Classification not possible" due to lack of data. |
8 | Specific target organ toxicity - Single exposure | Category 3 (Respiratory tract irritation) |
Warning |
H335 |
P304+P340
P403+P233 P261 P271 P312 P405 P501 |
It was classified in Category 3 (respiratory tract irritation) because it was irritating to the eyes, skin, and respiratory tract in humans, and it caused cough, sore throat, lethargy, nausea by inhalation (Environmental Risk Assessment for Chemical Substances vol. 9 (Ministry of the Environment, 2011)), and inhalation exposure caused a decrease in respiratory rate (RD50 = 58.1 ppm) in rats (IUCLID (2000)). Besides, it was classified in Xi; R36/37/38 in EU classification (EC-JRC (ESIS) (Access on June 2012)). |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (respiratory organs) |
Danger |
H372 |
P260
P264 P270 P314 P501 |
There is a report on hyperplasia and metaplasia of the respiratory epithelium at 0.017 mg/L in a 13-week inhalation exposure test with rats (Environmental Risk Assessment for Chemical Substances vol. 9 (Ministry of the Environment, 2011)), hyperplasia and metaplasia of the epithelium in the nasal cavity, bronchus, and lung and increased lung weight at 13 mg/m3 (converted guidance value: 0.004 mg/L) and 54 mg/m3 (converted guidance value: 0.016 mg/L) in a 4-week inhalation exposure test with rats (Environmental Risk Assessment for Chemical Substances vol. 9 (Ministry of the Environment, 2011)), and inflammatory changes in the olfactory epithelium at 0.001 mg/L, dyspnea and findings of chronic respiratory disease, increased lung weight, increased mortality, etc. at 0.01 (0.013) mg/L in a 25-month inhalation exposure test with rats (Environmental Risk Assessment for Chemical Substances vol. 9 (Ministry of the Environment, 2011)). Because all the above findings were observed within the guidance value range for Category 1, it was classified in Category 1 (respiratory system). Besides, it is described that long-term or repeated exposure may have effects on the respiratory tract and may result in tissue lesions in humans (Environmental Risk Assessment for Chemical Substances vol. 9 (Ministry of the Environment, 2011)). |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 1 |
Warning |
H400 |
P273
P391 P501 |
It was classified in Category 1 from 96-hour LC50 = 0.48 mg/L for fish (Lepomis macrochirus) (SIDS, 2001). |
11 | Hazardous to the aquatic environment (Long-term) | Category 1 |
Warning |
H410 |
P273
P391 P501 |
Reliable chronic toxicity data were not obtained. It was classified in Category 1 because it is not rapidly degradable (a degradation rate by BOD: 0% (SIDS, 2001)), and it corresponds to Category 1 in acute toxicity for fish (SIDS, 2001). |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. |
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