GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 90-05-1
Chemical Name 2-Methoxyphenol
Substance ID 24A6033
Classification year (FY) FY2012
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised New
Classification result in other fiscal year  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition)
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Solid (GHS definition)
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Solid (GHS definition)
5 Gases under pressure Not applicable
-
-
- - Solid (GHS definition)
6 Flammable liquids Not applicable
-
-
- - Solid (GHS definition)
7 Flammable solids Classification not possible
-
-
- - It is combustible from a flash point of 82 deg C (GESTIS (Access on June. 2012)), but the classification is not possible due to no data in the prescribed test.
8 Self-reactive substances and mixtures Not applicable
-
-
- - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable
-
-
- - Solid (GHS definition)
10 Pyrophoric solids Not classified
-
-
- - It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 385 deg C (GESTIS (Access on June 2012)).
11 Self-heating substances and mixtures Classification not possible
-
-
- - Test methods applicable to solid (melting point <= 140 deg C) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- - Solid (GHS definition)
14 Oxidizing solids Not applicable
-
-
- - The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
15 Organic peroxides Not applicable
-
-
- - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Classification not possible
-
-
- - It is a solid with a melting point of 55 deg C or lower, but the classification is not possible due to no data.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Category 4


Warning
H302 P301+P312
P264
P270
P330
P501
All three LD50 values for rats (520 mg/kg, 725 mg/kg (both Environmental Risk Assessment for Chemical Substances vol. 7 (Ministry of the Environment, 2009)), 1,500 mg/kg (PATTY (5th, 2001))) correspond to Category 4.
1 Acute toxicity (Dermal) Not classified
-
-
- - It was classified as "Not classified" in the Classification JIS (corresponding to Category 5 in UN GHS classification) based on an LD50 value of 4,600 mg/kg for rabbits (Environmental Risk Assessment for Chemical Substances vol. 7 (Ministry of the Environment, 2009)).
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible
-
-
- - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Category 4


Warning
H332 P304+P340
P261
P271
P312
It was classified in Category 4 based on an LC50 value by 2-hour exposure of 7.57 mg/L for mice (converted 4-hour equivalent value: 3.79 mg/L) (Environmental Risk Assessment for Chemical Substances vol. 7 (Ministry of the Environment, 2009)). Besides, because the LC50 value was higher than the saturated vapour pressure concentration (0.69 mg/L), it was regarded as a test on dust.
2 Skin corrosion/irritation Not classified
-
-
- - In a test in which 0.5 mL of this substance (100%) was applied to four rabbits for 4 hours (OECD TG404, GLP), erythema and edema were observed in all animals, the mean scores for erythema were not less than 1.3 and less than 2.3 in three out of four animals in evaluation at 24, 48, and 72 hours after removal of patches, the primary skin irritation index (PII) was 2.38 (ECETOC TR66 (1995)). Therefore, it was classified as "Not classified" in the Classification JIS (corresponding to Category 3 in UN GHS classification). Besides, there is also a report that strong irritation was shown in a test by a 24-hour application to rabbits (IUCLID (2000)). And it was classified in Xi: R36/38 in EU classification (EC-JRC (ESIS) (Access on June 2012)).
3 Serious eye damage/eye irritation Category 1


Danger
H318 P305+P351+P338
P280
P310
It was classified in Category 1 because it is described that severe irritation and necrosis were observed in a test by an application to rabbits (PATTY (5th, 2001)), and it is reported that an application of the small amount of undiluted this substance to the rabbit eye caused the serious injury of corneal necrosis and conjunctival damage (IUCLID (2000)). Besides, it was classified in Xi: R36/38 in EU classification (EC-JRC (ESIS) (Access on June 2012)).
4 Respiratory sensitization Classification not possible
-
-
- - No data available.
4 Skin sensitization Classification not possible
-
-
- - Data are lacking. Besides, it is reported that there were no positive sensitization reactions in a 48-hour patch test in 25 volunteers at a 2% concentration (Environmental Risk Assessment for Chemical Substances vol. 6 (Ministry of the Environment, 2008)), but the test details are unknown. Therefore, it was classified as "Classification not possible."
5 Germ cell mutagenicity Classification not possible
-
-
- - The classification is not possible due to no in vivo test data. Besides, as for in vitro tests, it was all negative in multiple Ames tests (JECFA 1002 (2001), NTP DB (1980)), but there is a report on positive results in a chromosomal aberration test with Syrian hamster embryo (SHE) cells (primary culture) and a chromosomal aberration test with human dental pulp fibroblast (primary culture) (Environmental Risk Assessment for Chemical Substances vol. 7 (Ministry of the Environment, 2009)).
6 Carcinogenicity Classification not possible
-
-
- - No data available.
7 Reproductive toxicity Classification not possible
-
-
- - No data available.
8 Specific target organ toxicity - Single exposure Category 1 (cardiovascular system), Category 3 (narcotic effects)



Danger
Warning
H370
H336
P308+P311
P260
P264
P270
P321
P405
P501
P304+P340
P403+P233
P261
P271
P312
It is reported that cardiovascular collapse occurred in a human who drank the unknown dose of this substance as an expectorant (Environmental Risk Assessment for Chemical Substances vol. 6 (Ministry of the Environment, 2008)). And it is described that this substance appears to be about one-third as toxic as phenol and to have pharmacological properties similar to phenol, and it causes muscular weakness, cardiovascular collapse, and paralysis of the vasomotor centers (PATTY (5th, 2001)). It was classified in Category 1 (cardiovascular system) based on the above knowledge. On the other hand, it was classified in Category 3 (narcotic effects) because drowsiness and coma were described as symptoms in an acute oral toxicity test with rats (LD50 value: 725 mg/kg) (IUCLID (2000)).
9 Specific target organ toxicity - Repeated exposure Classification not possible
-
-
- - In a test by 51-week diet administration of a 1.5% concentration to male rats, a significant increase in relative kidney weights was observed, and there is a report on slight to moderate hyperplasia in the forestomach, which was not found in the control group (Environmental Risk Assessment for Chemical Substances vol. 7 (Ministry of the Environment, 2009)), but data are lacking to assign a category. And effects in the other routes are unknown due to no data.
10 Aspiration hazard Classification not possible
-
-
- - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 3
-
-
H402 P273
P501
It was classified in Category 3 from 48-hour EC50 = 29.1 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 1998)).
11 Hazardous to the aquatic environment (Long-term) Category 3
-
-
H412 P273
P501
If chronic toxicity data are used, then it is classified in Category 3 due to rapid degradability (a degradation rate by BOD: 89.5% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1989)), and 21-day NOEC = 0.75 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 1998)).
If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified as "Not classified" due to its corresponding to "Not classified" in acute toxicity for fish (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 1998)), rapid degradability (a degradation rate by BOD: 89.5% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1989)), and a low bioaccumulation estimate (logKow = 1.32, PHYSPROP Database (2009)).
From the above results, it was classified in Category 3.
12 Hazardous to the ozone layer Classification not possible
-
-
- - This substance is not listed in the Annexes to the Montreal Protocol.


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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