Item | Information |
---|---|
CAS RN | 4418-26-2 |
Chemical Name | Sodium dehydroacetate |
Substance ID | 24A6021 |
Classification year (FY) | FY2012 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | New |
Classification result in other fiscal year | |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Solid (GHS definition) |
5 | Gases under pressure | Not applicable |
- |
- | - | Solid (GHS definition) |
6 | Flammable liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
7 | Flammable solids | Classification not possible |
- |
- | - | No data available. |
8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
9 | Pyrophoric liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
10 | Pyrophoric solids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 360 deg C (GESTIS (Access on May 2012)). |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to solid (melting point <= 140 deg C) substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | The substance does not contain metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) but contains sodium. Because this is ionically bonded, and there are data that it is 30% soluble in water (Gangolli (2nd, 1999)), therefore it is estimated that it does not react vigorously with water. |
13 | Oxidizing liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
14 | Oxidizing solids | Not applicable |
- |
- | - | The substance is an organic compound containing oxygen (but not halogen) which is chemically bonded only to carbon or hydrogen except for ionic bonding to sodium. |
15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure. |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 |
P301+P312
P264 P270 P330 P501 |
It was classified in Category 4 based on an LD50 value of 500 mg/kg for rats (RTECS (2010), the original article: Journal of the American College of Toxicology, Vol. 4 (3), Pg. 123, 1985) after confirming the description in the original article. |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | No data available. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | No data available. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | No data available. |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | No data available. |
3 | Serious eye damage/eye irritation | Not classified |
- |
- | - | In a test in which 0.1 mL of this substance was sprayed to the conjunctival sac of six rabbits from a distance of 6 inches for 48 seconds, the average irritation score (maximum 110) was 5, 1, 2, 0 at 1, 2, 3, 4 days after the application, respectively, and it was judged as minimally irritant, equivalent to the control group (RTECS (2010), the original article: Journal of the American College of Toxicology, Vol. 4 (3), Pg. 123, 1985). Therefore, it was classified as "Not classified." Besides, the content above was based on the original article of RTECS (2010), but it is described in RTECS (2010) that the test result was a mild irritation. |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. |
4 | Skin sensitization | Classification not possible |
- |
- | - | No data available. |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | It is described that it was weakly positive in a micronucleus test with mice (in vivo mutagenicity test) (HSDB (2003)), but the details are unknown. Therefore, it was classified as "Classification not possible." Besides, as for in vitro tests, it is reported that it was negative in an Ames test (HSDB (2003)), and positive in a chromosomal aberration test with fibroblast of Chinese hamsters (HSDB (2003)). |
6 | Carcinogenicity | Classification not possible |
- |
- | - | No data available. |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | In a test by oral administration to rats on gestational days 6-17, maternal and fetal weight gain was suppressed, and skeletal variations occurred in fetuses, but no teratogenicity was observed (Teratogenic (12th, 2007), corresponding to List 2). And in a test by oral administration to mice on gestational days 6-15, fetal lethality increased at the high dose (200 mg/kg), and 14th rib costa was found at all doses, but there were no significant defects including these (Teratogenic (12th, 2007)). The increased fetal lethality may be secondary effects of general toxicity, but the details are unknown. From the above, no teratogenicity or adverse effects on the development of offspring were seen. However, because data on sexual function and fertility are insufficient, it was classified as "Classification not possible." |
8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | No data available. |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | No data available. Besides, as related information, there is a report on an increase in lipid droplets in centrilobular and midlobular hepatocytes after 3-day or 7-day intraperitoneal administration of 120-300 mg/kg/day of this substance to mice, and an increase in liver weights mainly due to hyperplasia and fatty degeneration of the liver (the highest dose) in a test with rats fed diets containing 13 food additives including this substance for 1, 3, and 12 months (HSDB (2003)). |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Classification not possible |
- |
- | - | No data available. |
11 | Hazardous to the aquatic environment (Long-term) | Classification not possible |
- |
- | - | No data available. |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. |
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