NITE - Chemical Management Field

GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	288-32-4
Chemical Name	Imidazole
Substance ID	24A6013
Classification year (FY)	FY2012
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	New
Classification result in other fiscal year
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Solid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Solid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Solid (GHS definition)
6	Flammable liquids	Not applicable	- -	-	-	Solid (GHS definition)
7	Flammable solids	Classification not possible	- -	-	-	There is information that it is combustible (ICSC (J) (2012)), but there are no data in the prescribed test.
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not applicable	- -	-	-	Solid (GHS definition)
10	Pyrophoric solids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 480 deg C (ICSC (2008)).
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to solid (melting point <= 140 deg C) substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	- -	-	-	Solid (GHS definition)
14	Oxidizing solids	Not applicable	- -	-	-	Organic compounds containing no oxygen, fluorine or chlorine.
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure.
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	It was classified in Category 4 based on an LD50 value of 960-970 mg/kg for rats (SIDS (2004)).
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	No data available.
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	In a test in which 0.5 mL of paste-like test substance containing 80% of this substance and water was applied to the rabbit skin for 4 hours, severe erythema developed overnight and persisted by day 8 after the observation period, slight necrosis appeared overnight, and necrosis in all layers was pathologically observed after the observation period. As a result, this substance was assessed to be corrosive (SIDS (2004)). Therefore, it was classified in Category 1.
3	Serious eye damage/eye irritation	Category 2A	Warning	H319	P305+P351+P338 P337+P313 P264 P280	In a test in which 100 mg of the undiluted test substance was applied to the rabbit eye (OECD TG405; GLP), the irritation index, MMAS (equivalent to AOI), was 59.3, and it was assessed to be irritating (SIDS (2004)). Therefore, it was classified in Category 2A. And it is reported that in another test with rabbits using almost the same conditions as in the above (Federal Register 38 No. 178), the irritation index was 57.4, and it was irritating (SIDS (2004)), and it would also be classified in Category 2A with the results.
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.
4	Skin sensitization	Classification not possible	- -	-	-	No data available.
5	Germ cell mutagenicity	Not classified	- -	-	-	It was classified as "Not classified" based on a negative result in a micronucleus test with bone marrow after single oral administration to mice (OECD TG 474 GLP) (SIDS (2004)). Besides, as for in vitro tests, it was reported to be negative in an Ames test (SIDS (2004)).
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	It is reported that in a developmental toxicity test by oral administration to rats on days 6-19 of gestation (OECD TG 414; GLP), at the highest dose of 180 mg/kg/day where general maternal toxicity such as reduced food intake and reduced body weight gain appeared, an increase in the postimplantation loss occurred together with a high rate of late resorptions, and as external and skeletal malformations indicating teratogenicity, anasarca, cleft palate, shortened scapula, etc. significantly appeared (SIDS (2004)). Therefore, it was classified in Category 2.
8	Specific target organ toxicity - Single exposure	Category 2 (nervous system)	Warning	H371	P308+P311 P260 P264 P270 P405 P501	In an acute toxicity test with rats orally dosed 500-5,000 mg/kg (LD50 = 960-970 mg/kg), convulsions, disequilibria, lateral posture, and death were observed within 1 hour after administration, and survivors showed apathy, minor disequilibria, and accelerated respiration. Oral administration of 1,000 mg/kg to mice caused irregular respiration, piloerection, and closed eyelids (in some animals) after 15-30 minutes, and at 2,000 mg/kg, squatting posture was found in some animals including dead one (SIDS (2004)). Besides, the sign of trembling was also reported at 150 mg/kg, although it was after intraperitoneal administration to rats (SIDS (2004)). From the above, it was classified in Category 2 (nervous system) based on the general signs found within the dose range corresponding to the guidance values for Category 2.
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	In a 90-day repeated oral administration test with rats (OECD TG 408; GLP), centrilobular liver cell hypertrophy in males and females at the high dose of 180 mg/kg/day and accumulation of alpha 2-microglobulin in the proximal tubules the renal cortex in males at 180 mg/kg/day were reported as significant changes, but the dose was above the guidance value range (SIDS (2004)). On the other hand, in a 28-day repeated oral administration test with rats, decreases in hemoglobin and hematocrit values at or above 125 mg/kg/day (converted guidance value: 38.9 mg/kg/day), a decrease in red blood cell count at or above 250 mg/kg/day (converted guidance value: 77.8 mg/kg/day), hepatomegaly at or above 125 mg/kg/day, and an increase in kidney weights in males at or above 250 mg/kg/day were reported (SIDS (2004)). These findings were not adopted as evidence of the classification because effects in the kidney were most likely alpha 2-microglobulin nephropathy specific to male rats, and the changes in blood parameters in the 28-day repeated dose test were not seen in the 90-day repeated dose test, which was conducted later according to the international test guideline. And as for the liver, centrilobular liver cell hypertrophy at 180 mg/kg/day above the guidance value range after 90-day administration, hepatomegaly at or above 125 mg/kg/day (converted guidance value: 38.9 mg/kg/day) and increases in creatinine and ALT in males at 500 mg/kg/day (155.6 mg/kg/day) after 28-day administration were reported (SIDS (2004)), however, it was impossible to judge if there are adverse effects around the upper limit of the guidance values (100 mg/kg/day) due to lack of data. Therefore, it was classified as "Classification not possible."
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Not classified	- -	-	-	It was classified as "Not classified" because acute toxicity is not reported at 100 mg/L for algae, crustacea, and fish (SIDS, 2005).
11	Hazardous to the aquatic environment (Long-term)	Not classified	- -	-	-	If chronic toxicity data are used, then it is classified as "Not classified" due to rapid degradability (a degradation rate by BOD: 90% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 2003)), and 72-hour NOEC = 25 mg/L for algae (Desmodesmus subspicatus) (SIDS, 2005). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified as "Not classified" because it is not water-insoluble (water solubility = 159100 mg/L, PHYSPROP Database (2009)), and it corresponds to "Not classified" in acute toxicity for crustacea and fish (SIDS, 2005). From the above results, it was classified as "Not classified."
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

To GHS Information