GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 115-19-5
Chemical Name 3-Methyl-1-butyn-3-ol
Substance ID 24A6009
Classification year (FY) FY2012
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised New
Classification result in other fiscal year  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition)
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Classification not possible
-
-
- - There is a chemical group associated with explosive properties (acetylenes) in the molecule, but the classification is not possible due to no data.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Liquid (GHS definition)
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Liquid (GHS definition)
5 Gases under pressure Not applicable
-
-
- - Liquid (GHS definition)
6 Flammable liquids Category 2


Danger
H225 P303+P361+P353
P370+P378
P403+P235
P210
P233
P240
P241
P242
P243
P280
P501
It corresponds to Category 2 from a flash point of 20 deg C [closed-cup] (Bretherick (7th, 2007)) < 23 deg C and an initial boiling point of 104-105 deg C (Merck (14th, 2006)) > 35 deg C.
7 Flammable solids Not applicable
-
-
- - Liquid (GHS definition)
8 Self-reactive substances and mixtures Classification not possible
-
-
- - There is a chemical group associated with explosive properties (acetylenes) in the molecule, but the classification is not possible due to no data.
9 Pyrophoric liquids Not classified
-
-
- - It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 350 deg C (ICSC (2009)).
10 Pyrophoric solids Not applicable
-
-
- - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible
-
-
- - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- - The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to hydrogen.
14 Oxidizing solids Not applicable
-
-
- - Liquid (GHS definition)
15 Organic peroxides Not applicable
-
-
- - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Classification not possible
-
-
- - No data available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Category 4


Warning
H302 P301+P312
P264
P270
P330
P501
It was classified in Category 4 based on an LD50 value of 1420 mg/kg for rats (SIDS (1998)). Besides, as other LD50 values, there is a report on 1950 mg/kg (IUCLID (2000)), etc., and it is described that acute oral toxicity was tested in rats with the comparable results of LD50 values within the range of 1,300-2,600 mg/kg (SIDS (1998)).
1 Acute toxicity (Dermal) Not classified
-
-
- - It was classified as "Not classified" in the Classification JIS (corresponding to Category 5 in UN GHS classification or "Not classified") based on an LD50 value of > 2,000 mg/kg for rats (OECD TG402, GLP-compliant) (SIDS (1998)).
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible
-
-
- - There is a report on an LC50 value (4-hour exposure) of > 21.3 mg/L (> 6,194 ppm) for rats (OECD TG403) (SIDS (1998)), but the category cannot be determined with the data alone. Therefore, the classification is not possible. Besides, because the test concentration was lower than 90% of the saturated vapour pressure concentration, a reference value of gas was applied.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - No data available.
2 Skin corrosion/irritation Not classified
-
-
- - It was classified as "Not classified" on the basis that only a slight redness was observed in a test by a 20-hour occlusive application of this substance without dilution to the rabbit skin (SIDS (1998)).
3 Serious eye damage/eye irritation Category 1


Danger
H318 P305+P351+P338
P280
P310
It was classified in Category 1 because, in a test in which 50 microL of this substance was applied to the conjunctival sac of rabbits, staphyloma formation indicating an irreversible effect was observed after eight days, and it was judged to be a severe irritant (SIDS (1998)), and it is described that classification with R41 is necessary according to EU criteria (SIDS (1998)).
4 Respiratory sensitization Classification not possible
-
-
- - No data available.
4 Skin sensitization Classification not possible
-
-
- - There was no indication that this substance was a sensitizer in a skin sensitization test with guinea pigs (Split Adjuvant Test) (SIDS (1998)), but because the test method is not the one approved by OECD, it was classified as "Classification not possible."
5 Germ cell mutagenicity Not classified
-
-
- - It was classified as "Not classified" based on a negative result in a micronucleus test with erythrocytes after intraperitoneal administration to mice (in vivo somatic cell mutagenicity test) (OECD TG474, GLP-compliant) (SIDS (1998)). Besides, as for in vitro tests, it was reported to be negative in an Ames test (SIDS (1998)).
6 Carcinogenicity Classification not possible
-
-
- - No data available.
7 Reproductive toxicity Classification not possible
-
-
- - In a developmental toxicity test (OECD TG 414, GLP-compliant) in which pregnant rats were orally administered during the organogenesis period, fetuses showed an increase in delayed ossification of the skull bones, thoracic vertebral bodies, and sternebrae as well as a significant increase in the number of rudimentary cervical ribs and extra ribs at the high dose (400 mg/kg) where clinical symptoms (apathy, unsteady gait, piloerection) and body weight loss appeared in maternal animals, but no malformations were observed (SIDS (1998)). The above effects in fetuses were not used for classification because these were variations or delayed ossification, and no adverse effects on the development of offspring were shown in the test. However, because there are no data on sexual function and fertility, and effects on these are unknown, it was classified as "Classification not possible."
8 Specific target organ toxicity - Single exposure Category 3 (Narcotic effects)


Warning
H336 P304+P340
P403+P233
P261
P271
P312
P405
P501
A narcotic effect is described as symptoms seen in acute toxicity tests by oral or inhalation administration to rats (SIDS (1998)), and there is the knowledge that slight sedative effects on central nervous system functions were observed in a pharmacological test (SIDS (1998)). Therefore, it was classified in Category 3 (narcotic effects).
9 Specific target organ toxicity - Repeated exposure Classification not possible
-
-
- - In a 4-week repeated oral administration test with rats, at the high dose of 600 mg/kg/day (converted guidance value; 185 mg/kg/day), in addition to effects such as increased mortality, signs of sedation and narcosis, and reduced weight gain, as hematological changes, decreases in the number of leukocytes, hemoglobin concentration, and lymphocytes and increases in polymorphonuclear neutrophils, polychromasia, anisocytosis, and anulocytes were observed, and part of them was also seen (although slightly) at the dose of 200 mg/kg/day (converted guidance value; 62 mg/kg/day). And pathological findings were limited to the animals in the high dose group that died during the treatment, and hyperemia, focal bleeding, and erosive/ulcerative gastritis indicating irritation of the upper gastrointestinal tract were found, but histopathological changes supporting hematological changes were not seen (SIDS (1998)). Therefore, because no adverse effects were shown at the dose within the guidance value range, it can be regarded as "Not classified" in the oral route. However, there are no data and effects are unknown in the other routes. Therefore, it was classified as "Classification not possible" for specific target organ toxicity (repeated exposure).
10 Aspiration hazard Classification not possible
-
-
- - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Not classified
-
-
- - It was classified as "Not classified" because toxicity values are > 100 mg/L for all of the algae, crustacea, and fish (SIDS, 2002).
11 Hazardous to the aquatic environment (Long-term) Not classified
-
-
- - Reliable chronic toxicity data were not obtained. It was classified as "Not classified" because it is not water-insoluble (water solubility = 1000000 mg/L, PHYSPROP Database, 2012), and it corresponds to "Not classified" in acute toxicity for algae, crustacea, and fish (SIDS, 2002).
12 Hazardous to the ozone layer Classification not possible
-
-
- - This substance is not listed in the Annexes to the Montreal Protocol.


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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