Item | Information |
---|---|
CAS RN | 1072-52-2 |
Chemical Name | 2-(1-Aziridinyl)ethanol |
Substance ID | 24A6006 |
Classification year (FY) | FY2012 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | New |
Classification result in other fiscal year | |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Liquid (normal temperatures) (Sax (11th, 2004)) |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Liquid (normal temperatures) (Sax (11th, 2004)) |
5 | Gases under pressure | Not applicable |
- |
- | - | Liquid (normal temperatures) (Sax (11th, 2004)) |
6 | Flammable liquids | Category 4 |
Warning |
H227 |
P370+P378
P403+P235 P210 P280 P501 |
From a flash point of 85 deg C [open-cup] (HSDB (2006)), it was judged to be >60 deg C and <= 93 deg C in the prescribed closed-cup method, therefore it was classified in Category 4. Besides, there are data on a flash point of 67 deg C [unkonwn] (Lange (18th, 2005)), it was not adopted due to the unknown test method. |
7 | Flammable solids | Not applicable |
- |
- | - | Liquid (normal temperatures) (Sax (11th, 2004)) |
8 | Self-reactive substances and mixtures | Classification not possible |
- |
- | - | The substance does not contain chemical groups associated with explosive properties but contains a chemical group associated with explosive properties (aziridines), but there are no data. |
9 | Pyrophoric liquids | Classification not possible |
- |
- | - | No data available. |
10 | Pyrophoric solids | Not applicable |
- |
- | - | Liquid (normal temperatures) (Sax (11th, 2004)) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. |
14 | Oxidizing solids | Not applicable |
- |
- | - | Liquid (normal temperatures) (Sax (11th, 2004)) |
15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure. |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 3 |
Danger |
H301 |
P301+P310
P264 P270 P321 P330 P405 P501 |
It was classified in Category 3 from an LD50 value of 74 mg/kg for rats (HSDB (2006)). |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Data are lacking. Besides, as data in List 3, there is a report on an LD50 value of 71 microL/kg (= 77.2 mg/kg) for rabbits (RTECS (1998): the original article, Union Carbide Data Sheet (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817): 11/17/1964), corresponding to Category 2. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Liquid (normal temperatures) (Sax (11th, 2004)) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | No data available. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | No data available. |
2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 |
P302+P352
P332+P313 P362+P364 P264 P280 P321 |
This substance was classified in Category 2 because it is described that it was an irritant to the skin in humans (HSDB (2006)), and it is reported that there was severe irritation in a standard Draize test in which 500 microL was applied to the rabbit skin for 24 hours (RTECS (1998)). |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 |
P305+P351+P338
P280 P310 |
This substance it was classified in Category 1 because it is described that it was an irritant to the eye in humans (HSDB (2006)), and the extent of the corneal injury was rated 8 on a scale from 1 to 10 (most severe injury: 10) in a test by application to the rabbit eye (HSDB (2006)). |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. |
4 | Skin sensitization | Classification not possible |
- |
- | - | No data available. |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | The classification is not possible due to no in vivo test data. Besides, as for in vitro tests, it is reported that it was positive in both of an Ames test and a chromosomal aberration test with CHO cells (NTP DB (Access on Dec. 2011)). |
6 | Carcinogenicity | Classification not possible |
- |
- | - | It was classified as "Classification not possible" because it was classified in Group 3 in the IARC's carcinogenicity assessment (IARC Supplement 7 (1987)). Besides, it is reported that after subcutaneous injection to mice, the animals developed lymphosarcoma, fibrosarcoma, and adenosarcoma at injection sites, which were not observed in the control group (IARC 9 (1975)). |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | No data available. |
8 | Specific target organ toxicity - Single exposure | Category 1 (liver) |
Danger |
H370 |
P308+P311
P260 P264 P270 P321 P405 P501 |
It was classified in Category 1 (liver) because it is reported that liver necrosis occurred after single oral administration of the dose of 125-1,000 mg/kg bw corresponding to Category 1-2 to rats (IARC 9 (1975)). |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | Data are lacking. Besides, it is reported that 5-day oral administration of 10 mg/kg to rats caused depletion of the bone marrow and atrophy of the lymph nodes, thymus, and spleen (IARC 9 (1975)), but the details for classification are unknown. |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Classification not possible |
- |
- | - | No data available. |
11 | Hazardous to the aquatic environment (Long-term) | Classification not possible |
- |
- | - | No data available. |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. |
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