GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 142-83-6
Chemical Name 2,4-Hexadienal
Substance ID 24A6004
Classification year (FY) FY2012
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised New
Classification result in other fiscal year  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition)
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - The substance contains a chemical group associated with explosive properties, unsaturated C-C bond, but it is not 1,2-diene. Therefore, it was classified as "Not applicable."
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Liquid (GHS definition)
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Liquid (GHS definition)
5 Gases under pressure Not applicable
-
-
- - Liquid (GHS definition)
6 Flammable liquids Category 4
-
Warning
H227 P370+P378
P403+P235
P210
P280
P501
From a flash point of 67 deg C [closed-cup ] (Lange (16th, 2005)) > 60 deg C and <= 93 deg C, it corresponds to Category 4.
7 Flammable solids Not applicable
-
-
- - Liquid (GHS definition)
8 Self-reactive substances and mixtures Classification not possible
-
-
- - There is a chemical group associated with explosive properties (olefins ) in the molecule, and hazards are suggested such as causing severe polymerization or condensation (Hommel (1996)) or explosive polymerization (WebKis-Plus (Access on Apr. 2012)). However, the classification is not possible due to no test data.
9 Pyrophoric liquids Classification not possible
-
-
- - No data available.
10 Pyrophoric solids Not applicable
-
-
- - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible
-
-
- - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- - The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable
-
-
- - Liquid (GHS definition)
15 Organic peroxides Not applicable
-
-
- - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Not classified
-
-
- - There are no test data on corrosivity to metals. However, from a description that copper and aluminum are resistant (Hommel (1996)), it was classified as "Not classified."

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Category 3


Danger
H301 P301+P310
P264
P270
P321
P330
P405
P501
There is a report on two LD50 values for rats (300 mg/kg, 730 mg/kg) (JECFA 1094 (2004)), one each for Category 3 and Category 4. It was classified in Category 3, which was more hazardous.
1 Acute toxicity (Dermal) Category 3


Danger
H311 P302+P352
P361+P364
P280
P312
P321
P405
P501
It was classified in Category 3 based on an LD50 value of 270 microL/kg for rabbits (242.5 mg/kg) (PATTY (5th, 2001)).
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible
-
-
- - Data are lacking. Besides, there is a report on LCLo of 2,000 ppm/4 hours for rats (PATTY (5th, 2001)), but because the category cannot be determined, the classification is not possible. Because the toxicity value (2,000 ppm) was lower than 90% of the saturated vapour pressure concentration (6,329 ppm), a reference value of gas was applied.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - No data available.
2 Skin corrosion/irritation Category 1


Danger
H314 P301+P330+P331
P303+P361+P353
P305+P351+P338
P304+P340
P260
P264
P280
P310
P321
P363
P405
P501
In a test in which 0.5 mL of the undiluted test substance was applied to the rabbit skin for 4 hours, 4 out of 4 animals showed severe edema immediately after application and severe erythema 2-3 days after application, and the skin hardened and was stained brown. Furthermore, the treated skin was pitted on day 7 in two animals, and the primary skin irritation index was 7.08 (ECETOC TR66 (1995)). Therefore, it was classified in Category 1.
3 Serious eye damage/eye irritation Category 1


Danger
H318 P305+P351+P338
P280
P310
Although there are no eye irritation test data, because it was classified as a corrosive substance to the skin, it was classified in Category 1.
4 Respiratory sensitization Classification not possible
-
-
- - No data available.
4 Skin sensitization Classification not possible
-
-
- - Data are lacking. Besides, it is reported that there was one case of sensitization in a test on 59 volunteers given occlusive application of petroleum containing 1% of this substance (NTP TR509 (2003)), but the details on the test method and results are unknown.
5 Germ cell mutagenicity Not classified
-
-
- - It was classified as "Not classified" based on negative results in micronucleus tests with peripheral blood and bone marrow cells after repeated oral administration to mice (in vivo somatic cell mutagenicity test) (NTP DB (Access on Dec 2011)). Besides, as for in vitro tests, there are reports on positive (NTP DB (Access on Dec 2011), JECFA 1094 (2004)) or negative (JECFA 1094 (2004)) results in Ames tests.
6 Carcinogenicity Category 2


Warning
H351 P308+P313
P201
P202
P280
P405
P501
It was classified in Category 2 because it was classified in Group 2B in the IARC's carcinogenicity assessment (IARC 101 (2011)). Besides, it is reported that in 105-week oral administration tests with rats and mice, there was clear evidence of carcinogenicity in both animal species based on increased incidences of squamous cell neoplasms of the forestomach, and forestomach epithelial hyperplasia was observed and was associated with the administration of this substance (NTP TR509 (2003)).
7 Reproductive toxicity Classification not possible
-
-
- - No data available.
8 Specific target organ toxicity - Single exposure Classification not possible
-
-
- - No data available.
9 Specific target organ toxicity - Repeated exposure Classification not possible
-
-
- - Data are lacking. Besides, it is reported that in 14-week repeated oral administration tests with rats and mice, the incidence of forestomach hyperplasia was significantly increased at 120 mg/kg/day in both animal species (NTP TR509 (2003)), and in 16-day repeated oral administration tests with rats and mice, there were lesions indicative of forestomach necrosis and ulceration at 240 mg/kg/day (converted guidance value: 42.7 mg/kg/day) in both animal species, and forestomach epithelial hyperplasia was microscopically evident at 80 mg/kg/day (converted guidance value: 14.2 mg/kg/day) (NTP TR509 (2003)). Although effects were specifically observed in the forestomach of rats and mice within the dose range equivalent to the guidance values for Category 2, these were regarded as potential precursor lesions to neoplasia (NTP TR509 (2003)), and they were not adopted for specific target organ toxicity (repeated exposure) in this hazard class because the substance was classified in the carcinogenicity class.
10 Aspiration hazard Classification not possible
-
-
- - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible
-
-
- - No data available.
11 Hazardous to the aquatic environment (Long-term) Classification not possible
-
-
- - No data available.
12 Hazardous to the ozone layer Classification not possible
-
-
- - This substance is not listed in the Annexes to the Montreal Protocol.


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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