Item | Information |
---|---|
CAS RN | 7783-99-5 |
Chemical Name | silver nitrite |
Substance ID | 23B5575 |
Classification year (FY) | FY2011 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | Revised |
Classification result in other fiscal year | FY2006 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Classification not possible |
- |
- | - | The substance is a nitrite containing a chemical group associated with explosive properties (N-O), but the classification is not possible due to no data. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Solid (GHS definition) |
5 | Gases under pressure | Not applicable |
- |
- | - | Solid (GHS definition) |
6 | Flammable liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
7 | Flammable solids | Classification not possible |
- |
- | - | No data available. |
8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | It was classified as an oxidizing solid. |
9 | Pyrophoric liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
10 | Pyrophoric solids | Classification not possible |
- |
- | - | No data available. |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | No data available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | Because a water solubility value was obtained, it is stable in water. |
13 | Oxidizing liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
14 | Oxidizing solids | Category 2 |
Danger |
H272 |
P370+P378
P210 P220 P221 P280 P501 |
It is an inorganic compound containing oxygen, which is chemically bonded to elements other than carbon or hydrogen (N, Ag). It was classified as oxidizing in MSDS (Sigma-Aldrich) (Access on Sept. 2011), and it states that it is classified in Division 5.1, PG II in UNRTDG (UN2627 (NITRITES, INORGANIC, N.O.S.)). Therefore, it was classified in Category 2. |
15 | Organic peroxides | Not applicable |
- |
- | - | It is an inorganic compound. |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Classification not possible |
- |
- | - | No data available. Besides, as for health hazards, please refer to those for sodium nitrite (CAS RN 7632-00-0) and silver nitrate (I) (CAS RN 7761-88-8), the related compounds. |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | No data available. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | No data available. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | No data available. |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | No data available. Besides, it is described that silver nitrate, the related compound, is highly corrosive and may cause burns in the skin (NIOSH Publications (1978), corresponding to List 2). |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | No data available. Besides, it is described that silver nitrate, the related compound, is highly corrosive and may cause burns and irreversible damage in the eye (NIOSH Publications (1978)). |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. |
4 | Skin sensitization | Classification not possible |
- |
- | - | Silver is generally not considered a metal having dermal sensitization potential, but there have been rare instances and case reports in the scientific literature of individuals who have demonstrated an allergic reaction to silver or silver-containing materials (PATTY (5th, 2001)). However, it was classified as "Classification not possible" because no information specific to this substance was obtained. |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | No data available. Besides, some silver compound was reported to be negative in an Ames test and a chromosomal aberration test with CHO cells (both, in vitro mutagenicity tests) (IRIS (2003)). |
6 | Carcinogenicity | Classification not possible |
- |
- | - | No data available. Besides, it is described in IARC that there is limited evidence in humans for the carcinogenicity of nitrite in food, nitrite in food is associated with an increased incidence of stomach cancer, and there is limited evidence in experimental animals for the carcinogenicity of nitrite. Furthermore, IARC classified ingested nitrate or nitrite under conditions that result in endogenous nitrosation in 2A for carcinogenicity (IARC 94 (2010)). |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | It is reported that no effect on fertility was found in a test by oral administration of silver compounds to experimental animals by drinking water (ATSDR (1990)), and silver and silver compounds have not been associated with reproductive toxicity (PATTY (5th, 2001)), but there are no data specific to this substance. It was classified as "Classification not possible" due to lack of data. |
8 | Specific target organ toxicity - Single exposure | Category 1 (blood) |
Danger |
H370 |
P308+P311
P260 P264 P270 P321 P405 P501 |
It was classified in Category 1 (blood) because it is described that nitrite interacts with hemoglobin in human blood to generate methemoglobin, and high concentrations of methemoglobin are associated with hypotension, rapid pulse, and rapid breathing as a result of the vasodilatory effects of nitrite (IARC 94 (2010)). Besides, it is reported that due to exposure to dust containing relatively high levels of silver compounds such as silver nitrate or silver oxide, breathing problems, lung and throat irritation were seen in workers in chemical manufacturing facilities, and one man developed respiratory effects such as audible crackles during breathing, rapid pulse, a low oxygen content of capillary blood, and thickening of the lung observed in chest radiograms 14 hours after he had been working with molten silver ingots, his symptoms progressed to acute respiratory failure, from which he eventually recovered fully (ATSDR (1990)). |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (skin) |
Danger |
H372 |
P260
P264 P270 P314 P501 |
There is no information specific to this substance, but in humans, there are many case reports and epidemiological surveys in which long-term exposure to silver compounds caused deposition of silver in the skin, mucous membrane, or eye, and argyria. The change is not a toxic effect but an undesirable condition that is usually permanent (EPA RED (1992)). Therefore, it was classified in Category 1 (skin). |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Classification not possible |
- |
- | - | No data available. |
11 | Hazardous to the aquatic environment (Long-term) | Classification not possible |
- |
- | - | No data available. |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. |
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