GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 56-55-3
Chemical Name Benz[a]anthracene
Substance ID 23B5531
Classification year (FY) FY2011
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2006  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition)
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Solid (GHS definition)
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Solid (GHS definition)
5 Gases under pressure Not applicable
-
-
- - Solid (GHS definition)
6 Flammable liquids Not applicable
-
-
- - Solid (GHS definition)
7 Flammable solids Classification not possible
-
-
- - No data available.
8 Self-reactive substances and mixtures Not applicable
-
-
- - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable
-
-
- - Solid (GHS definition)
10 Pyrophoric solids Classification not possible
-
-
- - No data available.
11 Self-heating substances and mixtures Classification not possible
-
-
- - No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- - Solid (GHS definition)
14 Oxidizing solids Not applicable
-
-
- - Organic compounds containing no oxygen, fluorine or chlorine.
15 Organic peroxides Not applicable
-
-
- - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Classification not possible
-
-
- - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Classification not possible
-
-
- - No data available.
1 Acute toxicity (Dermal) Classification not possible
-
-
- - No data available.
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible
-
-
- - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - No data available.
2 Skin corrosion/irritation Classification not possible
-
-
- - No data available.
3 Serious eye damage/eye irritation Classification not possible
-
-
- - No data available.
4 Respiratory sensitization Classification not possible
-
-
- - No data available.
4 Skin sensitization Classification not possible
-
-
- - No data available.
5 Germ cell mutagenicity Category 2


Warning
H341 P308+P313
P201
P202
P280
P405
P501
It was classified in Category 2 from positive results in a chromosomal aberration test and a micronucleus test both with bone marrow after intraperitoneal administration to Chinese hamsters (in vivo somatic cell mutagenicity tests) (IARC 32 (1983)). Other than these, as in vivo somatic cell genotoxicity tests, there are reports on positive results in a sister chromatid exchange test with bone marrow after intraperitoneal administration to Chinese hamsters (IARC 32 (1983)), a DNA adduct formation test with the rat lung, and a DNA binding test with the mouse skin (EHC 202 (1998)). On the other hand, as for in vitro tests, mostly positive results were obtained in Ames tests (EHC 202 (1998), IARC 32 (1983)) and gene mutation tests with mouse lymphoma cells (NTP DB (Access on Oct. 2011)). Besides, there is a report on a positive result in a chromosomal aberration test with oocytes after oral administration to mice (in vivo germ cell mutagenicity test) (IARC 32 (1983)), but it was not used for classification because its reliability and validity are unknown.
6 Carcinogenicity Category 2


Warning
H351 P308+P313
P201
P202
P280
P405
P501
It was classified in Category 2 because IARC classified it in Group 2B (IARC 92 (2010)). Besides, it was classified in A2 by ACGIH (ACGIH (2001)), B2 by EPA (IRIS (1997)), and R by NTP (NTP RoC (12th, 2011)). Furthermore, in a test by intraperitoneal administration to mice, increases in lung and liver tumors were reported (IARC 92 (2010)). This substance is a relatively weak carcinogen compared to its alkyl derivatives or benzo[a]pyrene, but it acts as an initiator in tumor production in the mouse skin (ACGIH (2001)).
7 Reproductive toxicity Classification not possible
-
-
- - Data are lacking. Besides, it is described that subcutaneous injection of 5 mg/rat daily to two rats from the first day of pregnancy resulted in fetal death and resorption (IARC 32 (1983)).
8 Specific target organ toxicity - Single exposure Classification not possible
-
-
- - No data available.
9 Specific target organ toxicity - Repeated exposure Classification not possible
-
-
- - No data available.
10 Aspiration hazard Classification not possible
-
-
- - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1


Warning
H400 P273
P391
P501
It was classified in Category 1 from 3.7-day LC50 = 0.0018 mg/L for fish (Pimephales promelas) and 1.96-day LC50 = 0.0018 mg/L for crustacea (Daphnia magna) (both EHC, 1998).
11 Hazardous to the aquatic environment (Long-term) Category 1


Warning
H410 P273
P391
P501
Reliable chronic toxicity data were not obtained. It was classified in Category 1 because it is not rapidly degradable (BIOWIN), and it was classified in Category 1 in acute toxicity.
12 Hazardous to the ozone layer Classification not possible
-
-
- - This substance is not listed in the Annexes to the Montreal Protocol.


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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