GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 2439-35-2
Chemical Name 2-(Dimethylamino)ethyl acrylate
Substance ID 23B5520
Classification year (FY) FY2011
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2006  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition)
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Liquid (GHS definition)
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Liquid (GHS definition)
5 Gases under pressure Not applicable
-
-
- - Liquid (GHS definition)
6 Flammable liquids Category 4
-
Warning
H227 P370+P378
P403+P235
P210
P280
P501
It corresponds to Category 4 from a flash point of 61.7-68 deg C [closed-cup] (SIDS (2003)), which is > 60 deg C and <= 93 deg C.
7 Flammable solids Not applicable
-
-
- - Liquid (GHS definition)
8 Self-reactive substances and mixtures Type G
-
-
- - There is a chemical group associated with self-reactive properties (unsaturated bond, acrylate) present in the molecule, but commercial products are classified in Type G because there are classified in Division 6.1 in UNRTDG (UN3302, 16th, 2009) and are stabilized by hydroquinone derivatives, etc. (IMDG (2010)) (e.g., hydroquinone monomethyl ether (Chemical Substance Hazard Data (CERI, 2001))).
9 Pyrophoric liquids Not classified
-
-
- - It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 209 deg C (SIDS (2003)).
10 Pyrophoric solids Not applicable
-
-
- - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible
-
-
- - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- - The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable
-
-
- - Liquid (GHS definition)
15 Organic peroxides Not applicable
-
-
- - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Classification not possible
-
-
- - No data available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Category 4


Warning
H302 P301+P312
P264
P270
P330
P501
It was classified in Category 4 based on an LD50 value of 455 mg/kg for rats (OECD TG401, GLP) (SIDS (2003)).
1 Acute toxicity (Dermal) Category 3


Danger
H311 P302+P352
P361+P364
P280
P312
P321
P405
P501
Among two LD50 values for rats of 419 mg/kg and 891 mg/kg (both, OECD TG402, GLP) (SIDS (2003)), and an LD50 value of 50-200 mg/kg for rabbits (SIDS (2003)), based on data in rats according to the test guideline and GLP, it was classified in Category 3.
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Category 1


Danger
H330 P304+P340
P403+P233
P260
P271
P284
P310
P320
P405
P501
Both two LC50 values for rats of 0.927 mg/L/1 hour (158 ppm/1 hour = 83 ppm/4 hours) [OECD TG403, GLP] and 0.22 mg/L/4 hours (37.6 ppm/4 hours) (SIDS (2003)) correspond to Category 1. Besides, because the test concentrations were lower than 90% of the saturated vapour pressure concentration (671 ppm), the reference value of gases was applied as a vapour with little mist.
1 Acute toxicity (Inhalation: Dusts and mists) Category 2


Danger
H330 P304+P340
P403+P233
P260
P271
P284
P310
P320
P405
P501
It was classified in Category 2 based on an LC50 value of 0.066 mg/L/4 hours for rats [OECD TG403, GLP] (SIDS (2003)). Besides, the reference value of mists was applied because it is described that the test was conducted on aerosols (SIDS (2003)).
2 Skin corrosion/irritation Category 1


Danger
H314 P301+P330+P331
P303+P361+P353
P305+P351+P338
P304+P340
P260
P264
P280
P310
P321
P363
P405
P501
In a test in which 0.5 mL of the undiluted test substance was applied to six rabbits for 4 hours (OECD TG 404), corrosivity was seen in all the animals, and the primary dermal irritation index (PDII) was 8 (SIDS (2003)). Therefore, it was classified in Category 1. Besides, other than the above, results of two Draize tests with rabbits were reported, PII was 8 and 7.6, and it was assessed as corrosive in both (SIDS (2003)).
3 Serious eye damage/eye irritation Category 1


Danger
H318 P305+P351+P338
P280
P310
In a test in which 0.1 mL of the undiluted test substance was instilled into the eyes of two rabbits, and the eyes were rinsed 4 seconds after the instillation, both the animals displayed corneal, iris, conjunctival lesions within 1 hour, and it was judged as corrosive (SIDS (2003)). Therefore, it was classified in Category 1. Besides, it was also reported to be corrosive in another Draize test with rabbits (SIDS (2003)).
4 Respiratory sensitization Classification not possible
-
-
- - No data available.
4 Skin sensitization Category 1A


Warning
H317 P302+P352
P333+P313
P362+P364
P261
P272
P280
P321
P501
In a guinea pig maximization test (OECD TG406, GLP), after induction by intradermal administration of 0.5% of this substance, it was judged as sensitizing with a positive rate of 100% (20/20) (SIDS (2003)). Therefore, it was classified in Category 1A.
5 Germ cell mutagenicity Not classified
-
-
- - It was classified as "Not classified" based on a negative result in a micronucleus test with bone marrow cells after intraperitoneal administration to mice (in vivo somatic cell mutagenicity test) (OECD TG474, GLP) (SIDS (2003)). Besides, as for in vitro tests, it was reported to be positive in an Ames test and chromosomal aberration tests with CHL/IU cells or human lymphocytes (Toxicity Testing Reports of Environmental Chemicals (Chemicals Investigation Promoting Committee)(1997), SIDS (2003)).
6 Carcinogenicity Classification not possible
-
-
- - No data available.
7 Reproductive toxicity Category 2


Warning
H361 P308+P313
P201
P202
P280
P405
P501
In a developmental toxicity test by oral administration to pregnant rats during the organogenesis period (OECD TG414, GLP), an increase in post-implantation loss and an increase in malformations and anomalies such as dwarf fetuses, adactyly, cleft palate, hydrocephaly, and testicular ectopia were seen at a dose (100 mg/kg/day) where maternal animals showed general toxicity, including death (SIDS (2003)). Therefore, it was classified in Category 2. Besides, in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test by oral administration to rats (4-100 mg/kg/day) (OECD TG422, GLP), transiently reduced weight gain and decreased food consumption in paternal animals and death of two maternal animals were observed in the 100 mg/kg group, but there were no effects on sexual function and fertility, and no changes were found in the birth or survival of offspring (JECDB (Access on Sept. 2011)).
8 Specific target organ toxicity - Single exposure Category 1 (respiratory system, systemic toxicity)


Danger
H370 P308+P311
P260
P264
P270
P321
P405
P501
In an acute toxicity test by 4-hour inhalation (aerosol) in rats (LC50 = 0.066 mg/L) (OECD TG403, GLP), symptoms of gasping, rales, and lethargy were seen, and necropsy of dead animals revealed congestion and swelling of the lung and pulmonary edema (SIDS (2003)). Also, in an acute toxicity test by 1-hour inhalation (vapour) in rats (converted 4-hour equivalent value: LC50 = 0.486 mg/L) (OECD TG403, GLP), labored respiration and rales were observed, and at necropsy, dead animals had necrosis and purulent exudate in the nasal cavity, larynx, and trachea, and survived animals showed epithelial hyperplasia with keratinization in the larynx (SIDS (2003)). From the above, because doses were within the guidance value range for Category 1, it was classified in Category 1 (respiratory system). On the other hand, hypokinesia, sedation, piloerection, dyspnea, and tonic-clonic convulsions followed by death were found in an acute oral toxicity test with rats (80-2,000 mg/kg; LD50 = 455 mg/kg) (OECD TG401, GLP), and in an acute dermal toxicity test (200-2,000 mg/kg; LD50 = 419 mg/kg) (OECD TG402, GLP), a decrease in spontaneous activity was seen in all animals at all doses (SIDS (2003)), and the above effects were observed at doses corresponding to the guidance value range for Category 1 in both the routes. However, because it was impossible to specify the target organ, it was classified in Category 1 (systemic toxicity).
9 Specific target organ toxicity - Repeated exposure Category 2 (systemic toxicity)


Warning
H373 P260
P314
P501
In a 13-week repeated oral administration test with rats (OECD TG408, GLP), at the highest dose of 50 mg/kg/day, in addition to a high incidence of mortality, respiratory difficulties and a sign of ill health before death, and ptyalism and loud breathing in surviving animals were seen (SIDS (2003)). In histopathological investigations, effects related to the test substance were observed in the lung and forestomach for both dead and surviving animals, but it is mentioned that the lesions in the lung were caused by reflux of stomach contents (SIDS (2003)). Furthermore, it is reported that in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test by oral administration to rats (OECD TG 422, GLP), two females died in the highest dose of 100 mg/kg (converted guidance value: about 47 mg/kg/day), congestion, hemorrhage, and edema in the lung were found, and changes in the lung were considered to be a possible cause of death, and major pathological changes were lesions in the forestomach mucosa such as thickening, ulcer, and hyperplasia (JECDB (Access on Sept. 2011)). From the above, death occurred at doses corresponding to the guidance values for Category 2, and there were lesions in the forestomach and sporadic lung disorders, which were mentioned to be a possible cause of death. However, this substance is corrosive, and lesions in the forestomach were considered to be caused by local irritation, while lung disorders occurred in dead animals, which were not sufficient to specify the target organ. Therefore, it was classified in Category 2 (systemic toxicity).
10 Aspiration hazard Classification not possible
-
-
- - In experimental animals, there is a report on alveolar hemorrhage and edema and congestion in the lung, which were considered likely to be an irritative effect of regurgitation of stomach contents, and death by oral administration (SIDS (2003)), and because kinematic viscosity was 1.31 mm2/s (25 deg C) (viscosity 1.23 mPa・s, density 0.94 g/cm3 (SIDS (2003))), it corresponds to Category 2 in UN GHS classification. However, because Category 2 is not used in Classification JIS, it was classified as "Classification not possible."

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1


Warning
H400 P273
P391
P501
It was classified in Category 1 from 72-hour ErC50 = 0.88 mg/L for algae (Desmodesmus subspicatus) (SIDS, 2004).
11 Hazardous to the aquatic environment (Long-term) Category 2


-
H411 P273
P391
P501
If chronic toxicity data are used, then it is classified in Category 2 due to being rapidly degradable (it hydrolyzes in water to generate acrylic acid (readily biodegradable) and N,N-dimethylethanolamine (readily biodegradable) (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1993)), and 72-hour NOEC = 0.025 mg/L for algae (Pseudokirchneriella subcapitata) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 1996)).
If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified as "Not classified" due to being rapidly degradable (it hydrolyzes in water to generate acrylic acid (readily biodegradable) and N,N-dimethylethanolamine (readily biodegradable) (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1993)), and a low bioaccumulation estimate (log Kow = 0.42 (PHYSPROP Database, 2009)), despite 96-hour LC50 = 8.49 mg/L for fish (Oryzias latipes) (Environmental Risk Assessment for Chemical Substances Vol. 3 (Ministry of the Environment, 2004)).
From the above results, it was classified in Category 2.
12 Hazardous to the ozone layer Classification not possible
-
-
- - This substance is not listed in the Annexes to the Montreal Protocol.


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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