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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	151-56-4
Chemical Name	Aziridine
Substance ID	23B5511
Classification year (FY)	FY2011
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Liquid (GHS definition)
6	Flammable liquids	Category 2	Danger	H225	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	It corresponds to Category 2 from a flash point of -11 deg C [closed-cup] (HSDB (2006)), which is < 23 deg C, and an initial boiling point of 55 deg C (Hommel (1991)), which is > 35 deg C.
7	Flammable solids	Not applicable	- -	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Type G	- -	-	-	There is a chemical group associated with self-reactive properties (strained ring) present in the molecule, but commercial products including a stabilizer are classified in Division 6.1, Subsidiary Risk 3, PG I in UNRTDG (UN 1185) and are classified in Type G. Beside, maritime transport is prohibited for a pure substance, which is estimated to be Type A.
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 322 deg C (HSDB (2006)).
10	Pyrophoric solids	Not applicable	- -	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	- -	-	-	Organic compounds containing no oxygen, fluorine or chlorine.
14	Oxidizing solids	Not applicable	- -	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure.
16	Corrosive to metals	Classification not possible	- -	-	-	No data available. Besides, there is information that steel and stainless steel are resistant as a container (Hommel (1996)).

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 2	Danger	H300	P301+P310 P264 P270 P321 P330 P405 P501	It was classified in Category 2 based on an LD50 value of 15 mg/kg for rats (PATTY (5th, 2001)).
1	Acute toxicity (Dermal)	Category 1	Danger	H310	P302+P352 P361+P364 P262 P264 P270 P280 P310 P321 P405 P501	It was classified in Category 1 based on an LD50 value of 13 mg/kg bw for rabbits (PATTY (5th, 2001)).
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Liquid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Category 1	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	Both two LC50 values for rats [56 ppm by 2-hour exposure (converted 4-hour equivalent value: 39.6 ppm) (PATTY (5th, 2001)) and 15 ppm by 8-hour exposure (converted 4-hour equivalent value: 21.2 ppm) (ACGIH (2009))] correspond to Category 1. Besides, because the LC50 values were lower than the saturated vapour pressure concentration (280000 ppm), the reference value of gasses was applied as a vapour with little mist.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	It is reported that 24-hour non-occluded application of a 100 ppm concentration caused severe skin irritation in rabbits (HSDB (2006)), and it is described that depending on the concentration and length of exposure, signs of skin irritation include inflammation and blistering to deep necrosis, but skin irritation is evident after only 5 minutes. Therefore, it was classified in Category 1. Besides, the EU classified it in C; R34 (EC-JRC (ESIS) (Access on Sept. 2011)).
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	It is described that ethyleneimine has a potent irritating effect on the skin and mucous membranes, characterized by causing severe damage to the eye (Japanese journal of industrial health Vol. 32 (1990)). It was classified in Category 1 because application of 0.005 mL of the undiluted test substance or 0.5 mL of a 15% aqueous solution to the rabbit eye caused severe corneal injury, and it was assessed to be corrosive (IUCLID (2000)). Besides, the EU classified it in C; R34 (EC-JRC (ESIS) (Access on Sept. 2011)).
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.
4	Skin sensitization	Classification not possible	- -	-	-	In humans, there is one report that two laboratory workers developed skin sensitization (ACGIH (2001), Japanese Journal of industrial health Vol. 32 (1990)), but the details are unknown as to whether it was found in multiple dermatology clinics. Because no other data are indicating the sensitizing potential of this substance, and "SEN" was not assigned in ACGIH-TLV (2011), it was classified as "Classification not possible."
5	Germ cell mutagenicity	Category 1B	Danger	H340	P308+P313 P201 P202 P280 P405 P501	Dominant lethal tests by intraperitoneal or intrascrotal administration to male mice (in vivo heritable germ cell mutagenicity tests) gave positive results in both the routes (IARC 71 (1999), IUCLID (2000)). Therefore, it was classified in Category 1B. Besides, it was reported to be positive in an unscheduled DNA synthesis test with germ cells by intraperitoneal administration to mice (in vivo germ cell genotoxicity test) (IUCLID (2000)). As for in vitro tests, it was reported to be positive in all of an Ames test, a gene mutation test with Chinese hamster ovary cells, and chromosomal aberration tests with human WI-36 cells or leukocytes (NTP DB (2000), IARC 71 (1999)).
6	Carcinogenicity	Category 2	Warning	H351	P308+P313 P201 P202 P280 P405 P501	It was classified in Category 2 because it was classified in 2B by IARC (IARC 71 (1999)), 2B by the Japan Society for Occupational Health (JSOH) (Recommendation of Occupational Exposure Limits (Japan Society For Occupational Health (JSOH), 2010)), and A3 by ACGIH (ACGIH-TLV (2008)). Besides, after oral administration (gavage followed by feeding) to mice for 77-78 weeks, significant increases in incidences of hepatoma and lung tumors were reported (IARC 9 (1975)).
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	After 20-day inhalation exposure of pregnant rats to the 10 mg/m3 level, body weight gain of maternal animals was significantly depressed, and the relative number of pregnant animals was decreased (ACGIH (2001)). Also, after oral administration of 1.04 or 2.6 mg/kg to pregnant rats during the organogenesis period, the high dose group showed notably decreased body weight and vaginal bleeding as toxicity in maternal animals, and at the same doses, a significant decrease in live implantations and a significant increase in fetuses with malformations (spondylolysis) were observed (IUCLID (2000)). Because adverse reproductive effects were seen at the doses where general toxicity occurred in parent animals in both the tests above, it was classified in Category 2.
8	Specific target organ toxicity - Single exposure	Category 1 (central nervous system, respiratory system, kidney, liver)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	It is mentioned that acute inhalation or dermal exposure of workers manifests itself in central nervous system effects, excess fluid in the lungs, damage to the liver and kidneys, and in some cases, death (ACGIH (2009)). Also, in humans, corrosivity to the respiratory tract and ulceration of the upper respiratory tract were seen after short-term exposure (Environmental Risk Assessment for Chemical Substances vol. 4 (Ministry of the Environment, 2005)). On the other hand, in animal tests, it is described that cause of death from massive overexposure is due to central nervous system effects (PATTY (5th, 2001)), and delayed lung injury with congestion, edema, and hemorrhage, and kidney damage with proteinuria, hematuria, etc. were reported after inhalation exposure (ACGIH (2009)). Based on the above knowledge, it was classified in Category 1 (central nervous system, respiratory system, kidney, liver).
9	Specific target organ toxicity - Repeated exposure	Category 1 (respiratory system, kidney, liver)	Danger	H372	P260 P264 P270 P314 P501	As findings in an animal test by inhalation exposure, there is a description of delayed lung injury with congestion, edema, and hemorrhage, proteinuria, hematuria, and increased BUN as well as necrotic degeneration of renal tubular epithelium, which was histologically found (PATTY (5th, 2001)). Furthermore, in a test by 1.5-month inhalation exposure (4 hours/day) of rats to 5 ppm (vapour) corresponding to the guidance values for Category 1 (converted guidance value: 1.67 ppm (0.003 mg/L)), catarrhal bronchitis, diminishing lymphatic elements in the lymph glands, and degenerative changes in the liver and kidney were reported (ACGIH (2001)). Therefore, it was classified in Category 1 (respiratory system, kidney, liver).
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Category 3	- -	H402	P273 P501	It was classified in Category 3 from 24-hour EC50 = 14 mg/L for crustacea (Daphnia magna) (HSDB, 2006, etc.).
11	Hazardous to the aquatic environment (Long-term)	Category 3	- -	H412	P273 P501	Reliable chronic toxicity data were not obtained. It was classified in Category 3 because appropriate data on rapid degradability were not obtained, and it was classified in Category 3 in acute toxicity.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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