GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTES:
Updated date:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS number | 558-25-8 |
| Chemical name | Methanesulfonyl fluoride |
| Substance ID | 23A5188 |
| Fiscal year of classification conducted | FY2011 |
| Classifier(s) (Ministries) | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| New/Revised | New |
| Download in Excel format | Excel file |
| Item | Information |
|---|---|
| Guidance used for classification (External link) |
Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government （July, 2010）
Environmental Hazards: UN GHS Document （4th revised edition） |
| Definitions / Abbreviations (Excel file) | Definitions / Abbreviations |
| Model Label by MHLW (External link) | MHLW Website （in Japanese Only） |
| Model SDS by MHLW (External link) | MHLW Website （in Japanese Only） |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | It is a liquid at normal temperatures (GESTIS (Access on Dec. 2011)). |
| 3 | Aerosols | Not applicable | - | - | - | Not an aerosol product. |
| 4 | Oxidizing gases | Not applicable | - | - | - | It is a liquid at normal temperatures (GESTIS (Access on Dec. 2011)). |
| 5 | Gases under pressure | Not applicable | - | - | - | It is a liquid at normal temperatures (GESTIS (Access on Dec. 2011)). |
| 6 | Flammable liquids | Classification not possible | - | - | - | No data. |
| 7 | Flammable solids | Not applicable | - | - | - | It is a liquid at normal temperatures (GESTIS (Access on Dec. 2011)). |
| 8 | Self-reactive substances and mixtures | Classification not possible | - | - | - | There is a chemical group present in the molecule associated with a self-reactive property (sulfonyl halides), but the classification is not possible due to no data. |
| 9 | Pyrophoric liquids | Classification not possible | - | - | - | No data. |
| 10 | Pyrophoric solids | Not applicable | - | - | - | It is a liquid at normal temperatures (GESTIS (Access on Dec. 2011)). |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | No established test method suitable for liquid substances. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Classification not possible | - | - | - | No data. |
| 14 | Oxidizing solids | Not applicable | - | - | - | It is a liquid at normal temperatures (GESTIS (Access on Dec. 2011)). |
| 15 | Organic peroxides | Not applicable | - | - | - | An organic compound that does not contain -O-O- structure. |
| 16 | Corrosive to metals | Classification not possible | - | - | - | No data. |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 1 |  |
H300 |
P301+P310 P264 P270 P321 P330 P405 P501 |
From an LD50 value of 2 mg/kg bw for rats (HSDB (2007)), it was classified in Category 1. |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - |
Lack of data. Besides, even in original literature, details of a reported LD50 value of 24 mg/kg bw for rats (GESTIS (Access on Dec. 2011)) from List 3 are unknown. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | It is a liquid at normal temperatures (GESTIS (Access on Dec. 2011)). |
| 1 | Acute toxicity （Inhalation: Vapours） | Category 1 | |
H330 |
P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501 |
From an LC50 value of 1 ppm/7h (= 1.32 ppm/4h) for rats in a 7-hour exposure (HSDB (2007)), it was classified in Category 1. Besides, a reference value of gasses as a vapour with hardly included mist was applied because the LC50 value (1 ppm) is lower than 90 % of the saturated vapour pressure concentration (14342 ppm). |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | No data. |
| 2 | Skin corrosion/irritation | Category 1 |  |
H314 |
P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501 |
From the information that it is extremely destructive to tissues of skin (HSDB (2007)), it was classified in Category 1. |
| 3 | Serious eye damage/eye irritation | Category 1 | |
H318 |
P305+P351+P338 P280 P310 |
From the information that it is extremely destructive to tissues of eyes (HSDB (2007)), it was classified in Category 1. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | No data. |
| 4 | Skin sensitization | Classification not possible | - | - | - | No data. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | No data. |
| 6 | Carcinogenicity | Classification not possible | - | - | - | No data. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | No data. |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (nervous system, respiratory system) |  |
H370 |
P307+P311 P260 P264 P270 P321 P405 P501 |
This substance is known as an acetylcholinesterase inhibitor and a potent methylating agent (HSDB (2007)). Extremely toxic as an LC50 value (vapour) of 1.0 to 1.2 ppm (converted to a 4-hour equivalent: 0.0053 to 0.0064 mg/L) for rats in a 7-hour inhalation exposure (vapour) and the main symptoms caused by the acetylcholinesterase inhibition before deaths were reported. (RTECS (2009): original literature American Industrial Hygiene Association Journal (1979)) The information that inhalation in humans may be fatal as a result of spasm, inflammation and edema of the larynx and bronchi, chemical pneumonitis, and pulmonary edema (HSDB (2007)) indicates effects on the respiratory system as a methylating agent. The above information from List 2 corresponds to Category 2, but it was classified in Category 1 (nervous system, respiratory system) by the expert judgment. |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (nervous system) | |
H372 |
P260 P264 P270 P314 P501 |
Severe clinical signs by exposure of this substance known as an acetylcholinesterase inhibitor and a potent methylating agent to humans include muscle fasciculation, weakness, respiratory failure, central nervous system depression, confusion, delirium, and coma (HSDB (2007)). The above information from List 2 corresponds to Category 2, but it was classified in Category 1 (nervous system) by the expert judgment. Besides, as animal tests, 3-month inhalation exposure (vapour) to rats at low concentrations of 20 or 100 ppb (seven hours/day, five days/week) reported no adverse effects except significantly decreased cholinesterase in red blood cell and brain at 100 ppb (RTECS (2009): original literature American Industrial Hygiene Association Journal (1979)). |
| 10 | Aspiration hazard | Classification not possible | - | - | - | No data. |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | No data. |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | No data. |
| 12 | Hazardous to the ozone layer | Classification not possible | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
NOTES:
|
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Updated date:
|
2016/10/31 Addition of Rationale for the classification |