GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTES:
Updated date:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS number | 111-82-0 |
| Chemical name | Methyl dodecanoate |
| Substance ID | 23A5175 |
| Fiscal year of classification conducted | FY2011 |
| Classifier(s) (Ministries) | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| New/Revised | New |
| Download in Excel format | Excel file |
| Item | Information |
|---|---|
| Guidance used for classification (External link) |
Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government （July, 2010）
Environmental Hazards: UN GHS Document （4th revised edition） |
| Definitions / Abbreviations (Excel file) | Definitions / Abbreviations |
| Model Label by MHLW (External link) | MHLW Website （in Japanese Only） |
| Model SDS by MHLW (External link) | MHLW Website （in Japanese Only） |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 3 | Aerosols | Not applicable | - | - | - | Not an aerosol product. |
| 4 | Oxidizing gases | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 5 | Gases under pressure | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 6 | Flammable liquids | Not classified | - | - | - | A flash point of 139 degrees C [closed cup] (eChemPortal (ECHA CHEM) (Access on Dec.2011)) is above 93 degrees C. |
| 7 | Flammable solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not classified | - | - | - | It is conceivable that it does not ignite at normal temperatures from an ignition point of 220 degrees C (eChemPortal (ECHA CHEM) (Access on Dec.2011)). |
| 10 | Pyrophoric solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | No established test method suitable for liquid substances. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | An organic compound that contains oxygen which is not chemically bonded to elements other than carbon or hydrogen. |
| 14 | Oxidizing solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 15 | Organic peroxides | Not applicable | - | - | - | An organic compound that does not contain -O-O- structure. |
| 16 | Corrosive to metals | Classification not possible | - | - | - | No data. |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Not classified | - | - | - | From an LD50 value of >2000 mg/kg bw and no deaths at 2000 mg/kg in rats (Report on Toxicity Tests of Chemical Substances, MHLW (Access on Dec. 2011)), it was classified as "Not classified." |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | No data. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | No data. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Not classified | - | - | - |
From an LC50 value of >5 mg/L in 4 hours for rats (HPVIS related information eChemPortal (ECHA CHEM) (Access on Dec.2011), equivalent to List 2), it was classified as "Not classified." Besides, a reference value of mists was applied because there is the information that the saturated vapour concentration is 0.047 mg/L and administration method is "inhalation: aerosol." |
| 2 | Skin corrosion/irritation | Category 2 |  |
H315 |
P302+P352 P332+P313 P264 P280 P321 P362 |
From PII = 3.89 in a test using 3 rabbits (ECETOC TR66 (1995)), it was classified in Category 2. |
| 3 | Serious eye damage/eye irritation | Category 2B | No pictogram |
H320 |
P305+P351+P338 P337+P313 P264 |
A test using rabbits (3 animals, 24 hours, OECD TG405, GLP) reported that slight erythema in the conjunctiva reversed within 72 hours (HPVIS related information eChemPortal (ECHA CHEM) (Access on Dec.2011)). And there are two results as slightly irritating (OECD TG405) and one result as not irritating (GLP compliance) in other rabbit tests (above IUCLID (2000)). From the above, it was classified in Category 2B. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | No data. |
| 4 | Skin sensitization | Classification not possible | - | - | - | A test using guinea pigs (OECD TG406, GLP) reported not sensitizing (HPVIS related information eChemPortal (ECHA CHEM) (Access on Dec.2011)). But due to data from List 2 and no positive rate data of the positive control, it was classified as "Classification not possible" due to lack of data. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - |
The classification is not possible due to no in vivo test data. Besides, an Ames test (OECD TG471, 472, GLP) and a chromosomal aberration test using CHL cells (OECD TG 473, GLP) reported negative results as in vitro tests (Report on Toxicity Tests of Chemical Substances, MHLW (Access on Dec. 2011), HPVIS related information eChemPortal (ECHA CHEM) (Access on Dec.2011)). |
| 6 | Carcinogenicity | Classification not possible | - | - | - | No data. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - |
In a combined repeated dose toxicity study with reproductive/developmental toxicity test in rats (dose period: 14 days before mating through mating and gestation by lactation day 3, OECD TG 422, GLP), parent animals did not show test substance-related effects on sexual function and fertility including copulation ability, fertility ability, and observations in sex cycle and delivery. And child animals did not show dose-related abnormalities in external tests of neonates and steadily increased in body weights until lactation day 4. And they did not show stillborn and offspring died before lactation day 4, and dose-related abnormal signs in necropsy on lactation day 4. (Report on Toxicity Tests of Chemical Substances, MHLW (Access on Dec. 2011)) From the above, it corresponds to "Not classified" in sexual function and fertility, but it was classified as "Classification not possible" due to no data on teratogenicity. |
| 8 | Specific target organ toxicity - Single exposure | Category 3 （Narcotic effects） | |
H336 |
P304+P340 P403+P233 P261 P271 P312 P405 P501 |
On the basis that 4-hour inhalation exposure at 5.6mg/L in rats (OECD TG436, GLP) caused lethargy, round-back posture, and labored breathing after 1-hour exposure and the round-back posture persisted by day 2 (HPVIS related information eChemPortal (ECHA CHEM) (Access on Dec.2011)), it was classified in Category 3 (narcotic effects). Besides, administration by oral gavage at 2000 mg/kg in rats reported no death in both males and females and no abnormal pathological signs except soft stool in all animals considered to be effects of corn oil (Report on Toxicity Tests of Chemical Substances, MHLW (Access on Dec. 2011)). From the report, it corresponds to "Not classified" in an oral route. |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - |
A combined repeated oral dose toxicity study with reproductive/developmental toxicity test in rats (doses; 0, 250, 500 and 1000 mg/kg/day, dose period; 41 to 55 days, OECD TG 422, GLP) reported NOEL of 1000 mg/kg [converted to a 90-day equivalent: 455.6 to 611.1 mg/kg]. And signs observed more in groups dosed of test substance than in control group in necropsy and pathological test were not observed and indications of dose-related effects were not reported (Report on Toxicity Tests of Chemical Substances, MHLW (Access on Dec. 2011)). From the above, it is judged to be "Not classified" in the oral route, but it was classified as "Classification not possible" due to no data in other routes. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | No data. |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 1 |  |
H400 |
P273 P391 P501 |
It was classified in Category 1 from 48-hour EC50 = 0.23 mg/L for crustacea (Daphnia magna) and so on (Results of Eco-toxicity tests of chemicals conducted by Ministry of the Environment in Japan, 2004). |
| 11 | Hazardous to the aquatic environment （Long-term） | Category 2 | |
H411 |
P273 P391 P501 |
It was classified in Category 2 from rapid degradability (degradation by BOD: 78 % (the existing chemicals survey program, 2004)), 72-hour NOEC = 0.040 mg/L for algae (Pseudokirchneriella subcapitata), and 21-day NOEC = 0.081 mg/L for crustacea (Daphnia magna) (Results of Eco-toxicity tests of chemicals conducted by Ministry of the Environment in Japan, 2004). |
| 12 | Hazardous to the ozone layer | Classification not possible | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
NOTES:
|
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Updated date:
|
2016/10/31 Addition of Rationale for the classification |