GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTES:
Updated date:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS number | 75-59-2 |
| Chemical name | Tetramethylammonium hydroxide |
| Substance ID | 23A5174 |
| Fiscal year of classification conducted | FY2011 |
| Classifier(s) (Ministries) | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| New/Revised | New |
| Download in Excel format | Excel file |
| Item | Information |
|---|---|
| Guidance used for classification (External link) |
Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government （July, 2010）
Environmental Hazards: UN GHS Document （4th revised edition） |
| Definitions / Abbreviations (Excel file) | Definitions / Abbreviations |
| Model Label by MHLW (External link) | MHLW Website （in Japanese Only） |
| Model SDS by MHLW (External link) | MHLW Website （in Japanese Only） |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | "Solids" according to GHS definition. |
| 3 | Aerosols | Not applicable | - | - | - | Not an aerosol product. |
| 4 | Oxidizing gases | Not applicable | - | - | - | "Solids" according to GHS definition. |
| 5 | Gases under pressure | Not applicable | - | - | - | "Solids" according to GHS definition. |
| 6 | Flammable liquids | Not applicable | - | - | - | "Solids" according to GHS definition. |
| 7 | Flammable solids | Classification not possible | - | - | - | No data. |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | "Solids" according to GHS definition. |
| 10 | Pyrophoric solids | Not classified | - | - | - | It is conceivable that it does not ignite at normal temperatures from an ignition point of 470 degrees C (GESTIS (Access on Dec. 2011)). |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | No established test method suitable for solid substances with a melting point of 140 degrees C or lower. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | "Solids" according to GHS definition. |
| 14 | Oxidizing solids | Not applicable | - | - | - | An organic compound does not contain fluorine or chlorine but contains oxygen which is not chemically bonded to elements other than carbon or hydrogen. |
| 15 | Organic peroxides | Not applicable | - | - | - | An organic compound that does not contain -O-O- structure. |
| 16 | Corrosive to metals | Classification not possible | - | - | - |
No established test method suitable for solid substances. Besides, there is the information that this substance is corrosive to aluminum, tin, bronze, and zinc (Hommel (1996)). |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 2 |  |
H300 |
P301+P310 P264 P270 P321 P330 P405 P501 |
From an LD50 value of 34 to 50 mg/kg bw for rats (Report on Toxicity Tests of Chemical Substances, MHLW (2000)), it was classified in Category 2. |
| 1 | Acute toxicity （Dermal） | Category 2 | |
H310 |
P302+P350 P262 P264 P270 P280 P310 P322 P361 P363 P405 P501 |
From an LD50 value of 112 mg/kg bw for rats (SIAP (2006)), it was classified in Category 2. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | "Solids" according to GHS definition. |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | No data. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | No data. |
| 2 | Skin corrosion/irritation | Category 1 |  |
H314 |
P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280* P310 P321 P363 P405 P501 |
Edema, necrosis with severe erythema and hemorrhage were observed 24 hours after occlusive application of a pentahydrate of this substance moistened by water at doses of 25 to 1000 mg/kg to guinea pig skin and it was concluded to be "extremely severe corrosive irritant" to skin (SIAP (2006)). From the information, it was classified in Category 1. Besides, this substance is strong alkaline whose pH is 13.61 in a 10% aqueous solution (SIAP (2006)). |
| 3 | Serious eye damage/eye irritation | Category 1 | |
H318 |
P305+P351+P338 P280 P310 |
Because the pH of this substance is 13.61 in a 10% aqueous solution (SIAP (2006)) and a test using guinea pigs concluded that a pentahydrate of this substance was "extremely severe corrosive irritant" to skin (SIAP (2006)), it was classified in Category 1. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | No data. |
| 4 | Skin sensitization | Classification not possible | - | - | - | No data. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - |
The classification is not possible due to no in vivo test data. Besides, both an Ames test (OECD TG471, GLP) and a chromosomal aberration test using Chinese hamster CHL cells (OECD TG 473, GLP) reported negatives as in vitro tests (Report on Toxicity Tests of Chemical Substances, MHLW (2000)). |
| 6 | Carcinogenicity | Classification not possible | - | - | - | No data. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - |
As a result of an oral administration reproductive/developmental toxicity screening test in rats (OECD TG421, GLP), it was reported that general toxicity in parent animals in a high dose group such as decreases in food consumption and locomotor activity, incomplete eyelid opening/eyelid closure, decreased body weights were observed. But effects on reproductive parameters of days required for copulation, copulation index, fertility index, implantation index, gestation length, and delivery index were not observed. And effects on numbers of total offspring and live offspring, sex ratio, live birth index, and viability index, and external abnormality in neonates were not observed (SIAP (2006)). But it was classified as "Classification not possible" due to insufficient data on adverse effects on the development of the offspring including teratogenicity. |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (nervous system) |  |
H370 |
P307+P311 P260 P264 P270 P321 P405 P501 |
As a result of an acute oral toxicity test using rats (doses: 10, 15, 23, 34, 50 mg/kg (males), 23 mg/kg (females); OECD TG401, GLP), deaths at 34 mg/kg or higher and signs of a decrease in locomotor activity, hypothermia, incomplete eyelid opening/eyelid closure, ataxic gait, clonic convulsions, salivation, and bradypnea at 23 mg/kg or higher were observed. And an LD50 value of 34 to 50 mg/kg bw (males) was reported (Report on Toxicity Tests of Chemical Substances, MHLW (2000)). And as a result of an acute dermal toxicity test using rats (doses: 50, 100, 125 mg/kg (females), 100 mg/kg (males): GLP compliance), signs of a decrease in locomotor activity, irregular respiration, narrow palpebral fissure, and tonic-clonic convulsions were observed. And an LD50 value of 112 mg/kg (females) was reported. (SIAP (2006)). From signs such as ataxic gait, clonic convulsions, and salivation at 23 mg/kg in oral exposure and a sign of tonic-clonic convulsions at 100 mg/kg in dermal exposure in the above reports, it was classified in Category 1 (nervous system). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (nervous system) | |
H372 |
P260 P264 P270 P314 P501 |
As a result of a repeated dose 28-day oral toxicity test using rats (doses: 5, 10, 20 mg/kg/day) (OECD TG 407, GLP), a sign of salivation at 10 mg/kg/day (converted to a 90-day equivalent: 3.1 mg/kg/day) or higher was observed. And a dose-dependent decrease in heart weight at 5 mg/kg/day in males (converted to a 90-day equivalent: 1.55 mg/kg/day) or higher but histopathological changes were not observed. (Report on Toxicity Tests of Chemical Substances, MHLW (2000)) In addition, as a result of a 28-day repeated dermal administration toxicity test using rats (doses: males 5.5, 50, 120, 250 mg/kg/day, females 2.5, 5.5, 10, 50 mg/kg/day: OECD TG 410), convulsions and tremors followed by signs of lethargy were shown. And deaths at 50 mg/kg/day (converted to a 90-day equivalent: 15.5 mg/kg/day) or higher but no deaths and no clear toxic signs at 10 mg/kg/day or lower were observed. (SIAP (2006)) Because salvation, convulsions, and tremors were observed within a range of Category 1 in Guidance values in both oral and dermal routes in the above reports, it was classified in Category 1 (nervous system). |
| 10 | Aspiration hazard | Classification not possible | - | - | - | No data. |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | No data. |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | No data. |
| 12 | Hazardous to the ozone layer | Classification not possible | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
NOTES:
|
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Updated date:
|
2016/10/31 Addition of Rationale for the classification |