GHS Classification Result

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GENERAL INFORMATION

Item Information
CAS number 111-43-3
Chemical name Dipropyl ether
Substance ID 23A5167
Fiscal year of classification conducted FY2011
Classifier(s) (Ministries) Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
New/Revised New
Download in Excel format Excel file

REFERENCE INFORMATION

Item Information
Guidance used for classification (External link) Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010)
Environmental Hazards: UN GHS Document (4th revised edition)
Definitions / Abbreviations (Excel file) Definitions / Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS

Hazard class Classification Pictogram
(Code: symbol)
Signal word
Code
(Hazard statement)
Code
(Precautionary statement)
Rationale for the classification
1 Explosives Not applicable - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable - - - "Liquids" according to GHS definition.
3 Aerosols Not applicable - - - Not an aerosol product.
4 Oxidizing gases Not applicable - - - "Liquids" according to GHS definition.
5 Gases under pressure Not applicable - - - "Liquids" according to GHS definition.
6 Flammable liquids Category 2

Danger
H225
P303+P361+P353
P370+P378
P403+P235
P210
P233
P240
P241
P242
P243
P280
P501
A flash point of 21 degrees C [closed-cup] (ICSC (J) (2002)) which is < 23 degrees C, and a boiling point of 90.5 degrees C (ICSC (J) (2002)), correspond to Category 2.
Besides, it is classified in class 3PGII in UNRTDG (UN2384).
7 Flammable solids Not applicable - - - "Liquids" according to GHS definition.
8 Self-reactive substances and mixtures Not applicable - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - It is conceivable that it does not ignite at normal temperatures from an auto-ignition temperature of 188 degrees C (ICSC (J) (2002)).
10 Pyrophoric solids Not applicable - - - "Liquids" according to GHS definition.
11 Self-heating substances and mixtures Classification not possible - - - No established test method suitable for liquid substances.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - An organic compound does not contain fluorine or chlorine but contains oxygen which is not chemically bonded to elements other than carbon.
14 Oxidizing solids Not applicable - - - "Liquids" according to GHS definition.
15 Organic peroxides Not applicable - - - An organic compound that does not contain -O-O- structure.
16 Corrosive to metals Classification not possible - - - No data.

HEALTH HAZARDS

Hazard class Classification Pictogram
(Code: symbol)
Signal word
Code
(Hazard statement)
Code
(Precautionary statement)
Rationale for the classification
1 Acute toxicity (Oral) Classification not possible - - - No data.
1 Acute toxicity (Dermal) Classification not possible - - - No data.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - "Liquids" according to GHS definition.
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - An LC50 value is estimated to be more than 5304 ppm/4h from the information that a 30-minute inhalation exposure test up to the concentration of 15000 ppm in rats (converted to a 4-hour exposure equivalent concentration: 5304 ppm) reported no deaths (PATTY (5th, 2001)).
But it was classified as "Classification not possible" because the category cannot be determined.
Besides, a reference value of gasses as vapour with hardly included mist was applied because the test concentration is lower than 90 % of the saturated vapour pressure concentration (82237 ppm).
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - No data.
2 Skin corrosion/irritation Classification not possible - - - Lack of data.
Besides, there is the information that this substance is irritating to the skin (HSDB (2009)), but further details are unknown.
3 Serious eye damage/eye irritation Classification not possible - - - Lack of data.
Besides, there is the information that this substance is irritating to eyes (HSDB (2009)), but further details are unknown.
4 Respiratory sensitization Classification not possible - - - No data.
4 Skin sensitization Classification not possible - - - No data.
5 Germ cell mutagenicity Classification not possible - - - No data.
6 Carcinogenicity Classification not possible - - - No data.
7 Reproductive toxicity Classification not possible - - - No data.
8 Specific target organ toxicity - Single exposure Category 3 (Respiratory tract irritation, Narcotic effects)

Warning
H335
H336
P304+P340
P403+P233
P261
P271
P312
P405
P501
In a 30-minute inhalation exposure test in mice, the dose calculated to reduce the respiratory rate by 50 % (RD50) was reported to be11200 ppm, the anesthetic dose as defined by depression of the righting reflex was reported to be 11600 ppm, and all adverse responses were recoverable after cessation of exposure. (PATTY (5th, 2001))
Furthermore, in an inhalation test in mice, a mixed response appeared after cessation of the sensory irritation response due to pulmonary irritation and anesthesia resulted in a decrease in respiratory rate and tidal volume. (HSDB (2009))
On the other hand, there is the information that this substance is irritating the respiratory tract in human (HSDB (2009)).
From the above, it was classified in Category 3 (respiratory tract irritation, narcotic effects).
Besides, it is classified in R67 in EU classification (EC-JRC (ESIS) (Access on Nov. 2011)).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - No data.
10 Aspiration hazard Classification not possible - - - No data.

ENVIRONMENTAL HAZARDS

Hazard class Classification Pictogram
(Code: symbol)
Signal word
Code
(Hazard statement)
Code
(Precautionary statement)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - No data.
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - No data.
12 Hazardous to the ozone layer Classification not possible - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTES:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
   and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.



Updated date:
2016/11/16 Addition of Rationale for the classification

List of GHS Classification Results