Item | Information |
---|---|
CAS number | 1214-39-7 |
Chemical name | 6-(Benzylamino)purine |
Substance ID | 23A5149 |
Fiscal year of classification conducted | FY2011 |
Classifier(s) (Ministries) | Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE) |
New/Revised | New |
Download in Excel format | Excel file |
Item | Information |
---|---|
Guidance used for classification (External link) |
Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010)
Environmental Hazards: UN GHS Document (4th revised edition) |
Definitions / Abbreviations (Excel file) | Definitions / Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable | - | - | - | There are no chemical groups associated with explosive properties present in the molecule. |
2 | Flammable gases (including chemically unstable gases) | Not applicable | - | - | - | "Solids" according to GHS definition. |
3 | Aerosols | Not applicable | - | - | - | Not an aerosol product. |
4 | Oxidizing gases | Not applicable | - | - | - | "Solids" according to GHS definition. |
5 | Gases under pressure | Not applicable | - | - | - | "Solids" according to GHS definition. |
6 | Flammable liquids | Not applicable | - | - | - | "Solids" according to GHS definition. |
7 | Flammable solids | Classification not possible | - | - | - | No data. |
8 | Self-reactive substances and mixtures | Not applicable | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
9 | Pyrophoric liquids | Not applicable | - | - | - | "Solids" according to GHS definition. |
10 | Pyrophoric solids | Classification not possible | - | - | - | No data. |
11 | Self-heating substances and mixtures | Classification not possible | - | - | - | No data. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable | - | - | - | "Solids" according to GHS definition. |
14 | Oxidizing solids | Not applicable | - | - | - | An organic compound does not contain oxygen, fluorine, or chlorine. |
15 | Organic peroxides | Not applicable | - | - | - | An organic compound that does not contain -O-O- structure. |
16 | Corrosive to metals | Classification not possible | - | - | - | No established test method suitable for solid substances. |
Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
H302 |
P301+P312 P264 P270 P330 P501 |
On the basis of an LD50 value of 1300 mg/kg bw for rats (EPA RED (1994)), it was classified in Category 4. | |
1 | Acute toxicity (Dermal) | Not classified | - | - | - | On the basis of an LD50 value of > 5000 mg/kg bw for rabbits (EPA RED (1994)), it was classified as "Not classified." |
1 | Acute toxicity (Inhalation: Gases) | Not applicable | - | - | - | "Solids" according to GHS definition. |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible | - | - | - | No data. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Category 4 |
H332 |
P304+P340 P261 P271 P312 |
On the basis of an LC50 value of 5.2 mg/L in a 1-hour exposure to rats (converted to a 4-hour equivalent; 1.30 mg/L) (EPA RED (1994)), it was classified in Category 4. Besides, the test condition is considered to be dust because the test concentration is above the saturated vapour concentration (4.92E-08 mg/L). |
|
2 | Skin corrosion/irritation | Not classified | - | - | - |
As a result of an application of this substance (moistened by 0.5 mL of water) to six rabbits for 4 hours, all erythema showed in all animals after 30 to 60 minutes was cleared after 5 days, no edema was observed, and it was assessed as mild to slight irritant with a primary irritation index of 0.7. (HSDB (2009)) Therefore, it was classified as "Not classified" in JIS classification (Category 3 in UN GHS classification). |
3 | Serious eye damage/eye irritation | Category 2B |
|
H320 |
P305+P351+P338 P337+P313 P264 |
Because it was reported that moderate conjunctivitis shown in a test applied 50 mg to rabbits was cleared in 7 days (EPA RED (1994)), it was classified in Category 2B. |
4 | Respiratory sensitization | Classification not possible | - | - | - | No data. |
4 | Skin sensitization | Classification not possible | - | - | - |
There is the information that a test using 20 guinea pigs reported no skin sensitization (HSDB (2009)), but it was classified as "Classification not possible" due to unknown details in test method and so on. Besides, there is the information that it is not a skin sensitizer in humans (EPA RED FACTS (1994)). |
5 | Germ cell mutagenicity | Not classified | - | - | - |
On the basis of a negative result in a micronucleus test by oral administration to mice (in vivo mutagenicity test) (EPA RED (1994)), it was classified as "Not classified." Besides, a negative result in an Ames test was reported as an in vitro test (EPA RED (1994)). |
6 | Carcinogenicity | Classification not possible | - | - | - | No data. |
7 | Reproductive toxicity | Category 2 |
H361 |
P308+P313 P201 P202 P281 P405 P501 |
Because an oral administration developmental toxicity test using rats reported an increased incidence of hydrocephalus, unossified sternebrae, incompletely ossified phalanges, and malaligned sternebrae in fetuses at a dose of 175 mg/kg/day where general toxicity in maternal animals including decreases in weight gain and food consumption was observed (EPA RED (1994)), it was classified in Category 2. | |
8 | Specific target organ toxicity - Single exposure | Category 3 (Respiratory tract irritation) |
H335 |
P304+P340 P403+P233 P261 P271 P312 P405 P501 |
From the information that an inhalation toxicity test in rats reported that the main sign was labored breathing in treatment groups of 4.7 mg/L/4h or higher and the information that it is irritating to respiratory tract (HSDB (2009)), it was classified in Category 3 (respiratory tract irritation). Besides, there is the information that oral administration at 940 to 3000 mg/kg to rats reported that the main signs were decreased activity, ataxia, dyspnea, and tremors (EPA RED (1994)). |
|
9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - |
Because a NOEL of 1500 ppm (111 mg/kg/day) in a 13-week rat oral administration (diet) test which reported no adverse effects except decreases in weight gain and food consumption (EPA RED (1994)) is above a range of Category 2 in Guidance values, it corresponds to "Not classified" in an oral route. But it was classified as "Classification not possible" in specific target organ toxicity (repeated exposures) due to no data in other routes. |
10 | Aspiration hazard | Classification not possible | - | - | - | No data. |
Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 3 | - |
H402 |
P273 P501 |
From 48-hour EC50 = 20.5 mg/L for crustacea (Daphnia magna) (U.S. EPA: RED, 1994), it was classified in Category 3. |
11 | Hazardous to the aquatic environment (Long-term) | Category 3 | - |
H412 |
P273 P501 |
Reliable chronic toxicity data were not obtained. Due to lack of rapid degradability (BIOWIN), and acute toxicity Category 3, it was classified in Category 3. |
12 | Hazardous to the ozone layer | Classification not possible | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
2016/10/13 Addition of Rationale for the classification |