GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTES:
Updated date:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS number | 538-93-2 |
| Chemical name | Isobutylbenzene |
| Substance ID | 23A5131 |
| Fiscal year of classification conducted | FY2011 |
| Classifier(s) (Ministries) | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| New/Revised | New |
| Download in Excel format | Excel file |
| Item | Information |
|---|---|
| Guidance used for classification (External link) |
Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government （July, 2010）
Environmental Hazards: UN GHS Document （4th revised edition） |
| Definitions / Abbreviations (Excel file) | Definitions / Abbreviations |
| Model Label by MHLW (External link) | MHLW Website （in Japanese Only） |
| Model SDS by MHLW (External link) | MHLW Website （in Japanese Only） |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 3 | Aerosols | Not applicable | - | - | - | Not an aerosol product. |
| 4 | Oxidizing gases | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 5 | Gases under pressure | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 6 | Flammable liquids | Category 3 |  |
H226 |
P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
A flash point of 55 degrees C [closed cup] (NFPA (13th, 2006)), which is >= 23 degrees C and <= 60 degrees C, corresponds to Category 3. Besides, "UN2709 butylbenzenes" is classified in class 3PGIII in UNRTDG. |
| 7 | Flammable solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not classified | - | - | - | It is conceivable that it does not to ignite at normal temperatures from an ignition temperature of 427 degrees C (CRC (91st, 2010)). |
| 10 | Pyrophoric solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | No established test method suitable for liquid substances. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | An organic compound does not contain oxygen or halogen. |
| 14 | Oxidizing solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 15 | Organic peroxides | Not applicable | - | - | - | An organic compound that does not contain -O-O- structure. |
| 16 | Corrosive to metals | Classification not possible | - | - | - | No data. |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Not classified | - | - | - | From an LDLo value of 5000 mg/kg bw for rats (IUCLID (2000)), it was classified as "Not classified." |
| 1 | Acute toxicity （Dermal） | Not classified | - | - | - | On the basis that a test administrated 2000 mg/kg to rats (OECD TG 402) reported no death and an LD50 value of > 2000 mg/kg (IUCLID (2000)), it was classified as "Not classified." |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | No data. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | No data. |
| 2 | Skin corrosion/irritation | Category 2 |  |
H315 |
P302+P352 P332+P313 P264 P280 P321 P362 |
Clear erythema and slight edema observed in a test applied 0.5 mL to rabbits for 4 hours (OECD TG 404) recovered in 8 days after application, and it was assessed as moderately irritating (IUCLID (2000)). On the basis of the assessment, it was classified in Category 2. |
| 3 | Serious eye damage/eye irritation | Not classified | - | - | - |
It was assessed as slightly irritating in a test applied 0.1 mL to 3 rabbits (OECD TG 405). However, no iritis, corneal opacity in 1 only animal after 24 hours, conjunctival redness in 2 animals, a group average score 1.3 less than 2, and recovery in 7 days were reported (IUCLID (2000)). On the basis of the report, it was classified as "Not classified." |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | No data. |
| 4 | Skin sensitization | Not classified | - | - | - | On the basis that a maximization test using guinea pigs (OECD TG 406) reported no erythema and edema in a challenge and no evidence of delayed contact hypersensitivity from a positive rate of 0% (0/20) (IUCLID (2000)), it was classified as "Not classified." |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - |
The classification is not possible due to no in vivo test data. Besides, a negative in an Ames test is reported as an in vitro test (IUCLID (2000)). |
| 6 | Carcinogenicity | Classification not possible | - | - | - | No data. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | No data. |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - |
A dermal administration test of 2000 mg/kg in rats did not show death or systemic signs, but it showed only slight or clear erythema on skin sites of application, and normal observations in necropsy (IUCLID (2000)). Therefore, it corresponds to "Not classified" in dermal administration. But it was classified as "Classification not possible" in specific target organ toxicity (single exposure) because effects on other routes (oral, inhalation) are unknown due to no data. |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | No data. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | No data. |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | No data. |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | No data. |
| 12 | Hazardous to the ozone layer | Classification not possible | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
NOTES:
|
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Updated date:
|
2016/9/2 Addition of Rationale for the classification |