GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTES:
Updated date:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS number | 75-19-4 |
| Chemical name | Cyclopropane |
| Substance ID | 23A5121 |
| Fiscal year of classification conducted | FY2011 |
| Classifier(s) (Ministries) | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| New/Revised | New |
| Download in Excel format | Excel file |
| Item | Information |
|---|---|
| Guidance used for classification (External link) |
Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government （July, 2010）
Environmental Hazards: UN GHS Document （4th revised edition） |
| Definitions / Abbreviations (Excel file) | Definitions / Abbreviations |
| Model Label by MHLW (External link) | MHLW Website （in Japanese Only） |
| Model SDS by MHLW (External link) | MHLW Website （in Japanese Only） |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Symbol Signal word |
Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | "Gases" according to GHS definition. |
| 2 | Flammable gases （including chemically unstable gases） | Category 1 |  |
H220 |
P210 P377 P381 P403 |
Due to explosive limits of 2.41 to 10.3 (% by vol in air) (Merck (14th, 2006) which is not more than 13 %, it was classified in Category 1. Besides, it is classified in Class 2.1 in UNRTDG (UN 1027). |
| 3 | Aerosols | Not applicable | - | - | - | Not an aerosol product. |
| 4 | Oxidizing gases | Not classified | - | - | - | Because it is classified as flammable gases, it was classified as "Not classified." |
| 5 | Gases under pressure | Low pressure liquefied gas |  |
H280 |
P410+P403 |
A critical temperature of 124.4 degrees C (Hommel (1996)) is above + 65 degrees C. |
| 6 | Flammable liquids | Not applicable | - | - | - | "Gases" according to GHS definition. |
| 7 | Flammable solids | Not applicable | - | - | - | "Gases" according to GHS definition. |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | "Gases" according to GHS definition. |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | "Gases" according to GHS definition. |
| 10 | Pyrophoric solids | Not applicable | - | - | - | "Gases" according to GHS definition. |
| 11 | Self-heating substances and mixtures | Not applicable | - | - | - | "Gases" according to GHS definition. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | "Gases" according to GHS definition. |
| 13 | Oxidizing liquids | Not applicable | - | - | - | "Gases" according to GHS definition. |
| 14 | Oxidizing solids | Not applicable | - | - | - | "Gases" according to GHS definition. |
| 15 | Organic peroxides | Not applicable | - | - | - | "Gases" according to GHS definition. |
| 16 | Corrosive to metals | Classification not possible | - | - | - | No established test method suitable for gas substances. |
| Hazard class | Classification |
Symbol Signal word |
Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Classification not possible | - | - | - | No data. |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | No data. |
| 1 | Acute toxicity （Inhalation: Gases） | Not classified | - | - | - | From an LC50 value of > 20000 ppmV/4h based on a 2-hour LCLo of 282 mg/L for mice (163927 ppmV) (converted to a 4-hour equivalent value: 115914 ppmV) (PATTY (5th, 2001)), it was classified as "Not classified." |
| 1 | Acute toxicity （Inhalation: Vapours） | Not applicable | - | - | - | "Gases" according to GHS definition. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Not applicable | - | - | - | "Gases" according to GHS definition. |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | No data. |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | No data. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | No data. |
| 4 | Skin sensitization | Classification not possible | - | - | - | No data. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - |
Due to no in vivo test data, the classification is not possible. Besides, an Ames test in an in vitro test reports a negative (HSDB (2003)). |
| 6 | Carcinogenicity | Classification not possible | - | - | - |
No data. Besides, it is classified in Group 3 as Anaesthetics, volatile in IARC (IARC Suppl. 7 (1987)). |
| 7 | Reproductive toxicity | Classification not possible | - | - | - |
Lack of data. Besides, Birth Defects (3rd, 2000) reports that many anesthetics show teratogenicity in animal tests, skeletal anomalies predominate with general inhalation anesthetics, and cyclopropane induced multiple defects in mice and rats. But details of the data are unknown due to no more description. |
| 8 | Specific target organ toxicity - Single exposure | Category 3 （Narcotic effects） |  |
H336 |
P304+P340 P403+P233 P261 P271 P312 P405 P501 |
This substance used as an inhalation anesthetic shows anesthesia and CNS depression (PATTY (5th, 2001)). PATTY (5th, 2001) reports that mice exposed to 5.8 mmol/L exhibited anesthesia in 3 minutes recovered in 1.5 minutes, and HSDB (2003) reports that recovery is rapid, usually within 10 minutes after inhalation irrespective of the duration of exposure, therefore it was classified in Category 3 (narcotic effects). |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | No data. |
| 10 | Aspiration hazard | Not applicable | - | - | - | "Gases" according to GHS definition. |
| Hazard class | Classification |
Symbol Signal word |
Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | No data. |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | No data. |
| 12 | Hazardous to the ozone layer | Classification not possible | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
NOTES:
|
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Updated date:
|
2016/7/29 Addition of Rationale for the classification |