Item | Information |
---|---|
CAS number | 55-68-5 |
Chemical name | Phenylmercury nitrate |
Substance ID | 23A5113 |
Fiscal year of classification conducted | FY2011 |
Classifier(s) (Ministries) | Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE) |
New/Revised | New |
Download in Excel format | Excel file |
Item | Information |
---|---|
Guidance used for classification (External link) |
Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010)
Environmental Hazards: UN GHS Document (4th revised edition) |
Definitions / Abbreviations (Excel file) | Definitions / Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Classification not possible | - | - | - | There is a chemical group associated with explosive properties present in the molecule (nitrate ester), but no data. |
2 | Flammable gases (including chemically unstable gases) | Not applicable | - | - | - | "Solids" according to GHS definition. |
3 | Aerosols | Not applicable | - | - | - | Not an aerosol product. |
4 | Oxidizing gases | Not applicable | - | - | - | "Solids" according to GHS definition. |
5 | Gases under pressure | Not applicable | - | - | - | "Solids" according to GHS definition. |
6 | Flammable liquids | Not applicable | - | - | - | "Solids" according to GHS definition. |
7 | Flammable solids | Classification not possible | - | - | - | No data. |
8 | Self-reactive substances and mixtures | Classification not possible | - | - | - | There is a chemical group associated with explosive properties present in the molecule (nitrate ester), but no data. |
9 | Pyrophoric liquids | Not applicable | - | - | - | "Solids" according to GHS definition. |
10 | Pyrophoric solids | Classification not possible | - | - | - | No data. |
11 | Self-heating substances and mixtures | Classification not possible | - | - | - | No data. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified | - | - | - | It contains a metal (Hg), but it is conceivable that it does not react vigorously with water from data on water solubility as 344 mg/L (25 degrees C) (SRC PhysProp (Access on July. 2011)). |
13 | Oxidizing liquids | Not applicable | - | - | - | "Solids" according to GHS definition. |
14 | Oxidizing solids | Classification not possible | - | - | - | Although an organic compound does not contain fluorine or chlorine but contains oxygen atoms which are chemically bonded to nitrogen, the classification is not possible due to lack of data. |
15 | Organic peroxides | Not applicable | - | - | - | An organic compound that does not contain -O-O- structure. |
16 | Corrosive to metals | Classification not possible | - | - | - | No established test method suitable for solid substances. |
Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Classification not possible | - | - | - |
No data. Besides, it is classified in T; R25 in EU classification (EC-JRC (ESIS) (Access on July. 2011)). |
1 | Acute toxicity (Dermal) | Classification not possible | - | - | - | No data. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable | - | - | - | It is a solid at normal temperatures (Merck (14th, 2006)). |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible | - | - | - | No data. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible | - | - | - | No data. |
2 | Skin corrosion/irritation | Category 2 |
H315 |
P302+P352 P332+P313 P264 P280 P321 P362 |
Positive results obtained in 24 out of 25 subjects by application of petrolatum containing 0.5% of this substance after induction in a human skin sensitization test, which reported a concentration with apparent irritation to be probably the cause, indicated irritation of this substance. (DFGMAK-Doc. 15 (2001)). Furthermore, there is information that a concentrated solution of phenylmercuric salts is irritating to skin (HSDB (2009)), therefore, it was classified in Category 2. Besides, this substance, phenylmercuric salts, and basic phenylmercuric nitrate are classified in C; R34 in EU classification (EC-JRC (ESIS) (Access on July. 2011)). |
|
3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | No data. |
4 | Respiratory sensitization | Classification not possible | - | - | - | No data. |
4 | Skin sensitization | Category 1A |
H317 |
P302+P352 P333+P313 P261 P272 P280 P321 P363 P501 |
Mercury itself or its compound is designated as a sensitizing substance (skin; Group 1) by Japan Society for Occupational Health (Journal of Occupational Health Vol.52 (2010)). Multiple reports suspected this substance to be a skin sensitizer in humans - 7 out of 759 (0.9%) dermatitis patients who reacted to preparation containing 0.05% of this substance, showed sensitization (DFGMAK-Doc. 15 (2001)), sensitization to this substance occurred in 1.7% in tests with 950 patients every year from 1990 to 1994 (DFGMAK-Doc. 15 (2001)), and this substance in spermicide caused allergic balanitis (DFGMAK-Doc. 15 (2001)). Therefore, it is classified in Category 1A. Besides, the DFG designates an organomercury compound as Sh (MAK/BAT (2010)). |
|
5 | Germ cell mutagenicity | Classification not possible | - | - | - | No data. |
6 | Carcinogenicity | Classification not possible | - | - | - | No data. |
7 | Reproductive toxicity | Category 2 |
H361 |
P308+P313 P201 P202 P281 P405 P501 |
There is no information about this substance, but animal tests show reproductive toxicity of mercury (ACGIH (2001)). Phenylmercuric acetate, which shows teratogenicity in multiple animals species such as central nervous system, eye, and tail defects in mice, multiple anomalies in rats and rabbits, and exencephaly in hamsters, is reported to be a potent teratogen (BirthDefects (3rd,2000), corresponding to List 2). In addition, oral administration to hamsters, rats, rabbits from 5th to 12th day of pregnancy reported fetal resorption, dead fetuses, and retardation of development, and teratogenic effects such as diminished cranial ossification, edemata of a body, hematoma, and open eyes (HSDB (2009)). From the above, corresponding to Category 1 is conceivable, but it was classified in Category 2 due to data about an analog substance. |
|
8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - | No data. |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (central nervous system, kidney) |
H372 |
P260 P264 P270 P314 P501 |
There is no information about this substance, but ACGIH-TLV (2011) describes central nervous system changes and kidney effects about aryl mercury compounds. From the information that a farmer who used phenylmercuric acetate developed severe neurological toxicity (ATSDR (1999)), and from the information that kidney damage at 0.042mg/kg/day or higher and renal lesions in both males and females at 0.21mg/kg/day or higher were observed in a 2-year diet administration test in rats (IRIS (2002)) (both are within range of Category 1 in Guidance values), it was classified in Category 1 (central nervous system, kidney). |
|
10 | Aspiration hazard | Classification not possible | - | - | - | No data. |
Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Classification not possible | - | - | - | No data. |
11 | Hazardous to the aquatic environment (Long-term) | Classification not possible | - | - | - | No data. |
12 | Hazardous to the ozone layer | Classification not possible | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
2016/8/17 Addition of Rationale for the classification |