GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTES:
Updated date:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS number | 1929-77-7 |
| Chemical name | S-Propyl N,N-dipropylthiocarbamate |
| Substance ID | 23A5095 |
| Fiscal year of classification conducted | FY2011 |
|
Classifier(s) (Ministries) |
Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| New/Revised | New |
| Download in Excel format | Excel file |
| Item | Information |
|---|---|
|
Guidance used for classification (External link) |
Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document （4th revised edition） |
|
Definitions / Abbreviations (Excel file) |
Definitions / Abbreviations |
|
Model Label by MHLW (External link) |
MHLW Website （in Japanese Only） |
|
Model SDS by MHLW (External link) |
MHLW Website （in Japanese Only） |
|
OECD/eChemPortal (External link) |
eChemPortal |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - |
There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - |
It is a liquid at normal temperatures. (Merck (14th, 2006)) |
| 3 | Aerosols | Not applicable | - | - | - |
Not an aerosol product. |
| 4 | Oxidizing gases | Not applicable | - | - | - |
It is a liquid at normal temperatures. (Merck (14th, 2006)) |
| 5 | Gases under pressure | Not applicable | - | - | - |
It is a liquid at normal temperatures. (Merck (14th, 2006)) |
| 6 | Flammable liquids | Not classified | - | - | - |
Because a flash point of above 93 degrees C in a prescribed closed-cup test method may be judged from 121 degrees C [unkown] (Gangolli (2nd, 1999)), it was classified as "Not classified." |
| 7 | Flammable solids | Not applicable | - | - | - |
It is a liquid at normal temperatures. (Merck (14th, 2006)) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - |
There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Classification not possible | - | - | - |
No data. |
| 10 | Pyrophoric solids | Not applicable | - | - | - |
It is a liquid at normal temperatures. (Merck (14th, 2006)) |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - |
No established test method suitable for liquid substances. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - |
Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - |
An organic compound that contains oxygen which is not chemically bonded to elements other than carbon or hydrogen. |
| 14 | Oxidizing solids | Not applicable | - | - | - |
It is a liquid at normal temperatures. (Merck (14th, 2006)) |
| 15 | Organic peroxides | Not applicable | - | - | - |
An organic compound that does not contain -O-O- structure. |
| 16 | Corrosive to metals | Classification not possible | - | - | - |
No data. |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 4 |
 |
H302 |
P301+P312 P264 P270 P330 P501 |
From an LD50 value of 1780 mg/kg for rats (EHC 76 (1988)), it was classified in Category 4. |
| 1 | Acute toxicity （Dermal） | Not classified | - | - | - |
From an LD50 value of >5000 mg/kg for rats (HSDB (2010)), it was classified as "Not classified." |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - |
It is a liquid at normal temperatures. (Merck (14th, 2006)) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - |
No data. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - |
No data. |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - |
No data. Besides, details of the information that it is "no skin irritation" (HSDB (2010)) is unknown. |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - |
No data. Besides, details of the information that it is "irritating to eyes" (HSDB (2010)) is unknown. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - |
No data. |
| 4 | Skin sensitization | Classification not possible | - | - | - |
No data. |
| 5 | Germ cell mutagenicity | Not classified | - | - | - |
From a negative result in a micronucleus test using bone marrow after an oral administration to mice (in vivo somatic cell mutagenicity test) (HSDB (2010)), it was classified as "Not classified." Besides, an Ames test reported a negative as an in vitro test. (HSDB (2010)) |
| 6 | Carcinogenicity | Classification not possible | - | - | - |
No data. |
| 7 | Reproductive toxicity | Category 2 |
 |
H361 |
P308+P313 P201 P202 P281 P405 P501 |
In a developmental toxicity test using rats by oral administration on day 6 to 20 of gestation, increased numbers of fetuses with moderate-to-serious skeletal anomalies were observed at the dose where maternal animals showed general toxicity such as decreased body weight gain and increased liver weights. (HSDB (2010)) And in a two-generation reproductive test using rats, a decrease in fetal body weights and a decreased number of the normal offspring judged by skeletal analysis were reported. (HSDB (2010)) Therefore it was classified in Category 2. Besides, adverse effects on sexual function and fertility were not reported in the two-generation reproductive test in rats. (IRIS (2004)) |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - |
Lack of data. Besides, there is the information that neuron cell lesions and neurotoxicity symptoms observed in an acute neurotoxicity test was consistent with cholinesterase inhibition, but doses were unknown (IRIS RED (1999)). |
| 9 | Specific target organ toxicity - Repeated exposure |
Category 2 (blood system) |
|
H373 |
P260 P314 P501 |
In a 1-year oral administration test (capsule) in dogs, increases in hemosiderin deposition and extramedullary hematopoiesis in the spleen at 20 mg/kg/day or higher, and anemia with significant decreases in hemoglobin levels, hematocrit, and red blood cell counts, and also elevated platelet counts, brown pigment accumulation in liver reticuloendothelial cells and kidney tubular epithelium, hypercellular sternal bone marrow, and so on at 100 mg/kg/day were observed. (HSDB (2010)) The above signs are within a range of Category 2 in Guidance values, therefore, it was classified in Category 2 (blood system). Besides, occasional axonal degeneration in cervical and lumbar spinal cord observed at 100 mg/kg/day (HSDB (2010)) was not used as a basis for classification because that was from List 2 data and was a low frequent change observed only in the high-dose group (100 mg/kg/day) corresponding to the upper limit in Guidance values. |
| 10 | Aspiration hazard | Classification not possible | - | - | - |
No data. |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 1 |
 |
H400 |
P273 P391 P501 |
It was classified in Category 1 from 96-hour LC50 = 0.23 mg/L for crustacea (Asellus communis) (EHC 76, 1988). |
| 11 | Hazardous to the aquatic environment （Long-term） | Category 1 |
|
H410 |
P273 P391 P501 |
Reliable chronic toxicity data were not obtained. Due to lack of rapid degradability (BIOWIN), and acute toxicity Category 1, it was classified in Category 1. |
| 12 | Hazardous to the ozone layer | Classification not possible | - | - | - |
This substance is not listed in Annexes to the Montreal Protocol. |
NOTES:
|
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |
Updated date:
|
2017/3/31 Addition of Rationale for the classification |