GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTES:
Updated date:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS number | 135-88-6 |
| Chemical name | 2-(N-Phenylamino)naphthalene |
| Substance ID | 23A5088 |
| Fiscal year of classification conducted | FY2011 |
|
Classifier(s) (Ministries) |
Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| New/Revised | New |
| Classification in other fiscal years | FY2013 (latest) |
| Download in Excel format | Excel file |
| Item | Information |
|---|---|
|
Guidance used for classification (External link) |
Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document （4th revised edition） |
|
Definitions / Abbreviations (Excel file) |
Definitions / Abbreviations |
|
Model Label by MHLW (External link) |
MHLW Website （in Japanese Only） |
|
Model SDS by MHLW (External link) |
MHLW Website （in Japanese Only） |
|
OECD/eChemPortal (External link) |
eChemPortal |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - |
There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - |
"Solids" according to GHS definition. |
| 3 | Aerosols | Not applicable | - | - | - |
Not an aerosol product. |
| 4 | Oxidizing gases | Not applicable | - | - | - |
"Solids" according to GHS definition. |
| 5 | Gases under pressure | Not applicable | - | - | - |
"Solids" according to GHS definition. |
| 6 | Flammable liquids | Not applicable | - | - | - |
"Solids" according to GHS definition. |
| 7 | Flammable solids | Classification not possible | - | - | - |
No data. |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - |
There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not applicable | - | - | - |
"Solids" according to GHS definition. |
| 10 | Pyrophoric solids | Classification not possible | - | - | - |
No data. |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | No established test method suitable for solid substances with a melting point of 140 degrees C or lower. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - |
Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - |
"Solids" according to GHS definition. |
| 14 | Oxidizing solids | Not applicable | - | - | - |
An organic compound that does not contain oxygen, fluorine, or chlorine. |
| 15 | Organic peroxides | Not applicable | - | - | - |
An organic compound that does not contain -O-O- structure. |
| 16 | Corrosive to metals | Classification not possible | - | - | - |
No established test method suitable for solid substances. |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Not classified | - | - | - |
From an LD50 value of 8730 mg/kg bw for rats (IARC 16 (1978)), it was classified as "Not classified." |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - |
No data. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - |
"Solids" according to GHS definition. |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - |
No data. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - |
No data. |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - |
No data. Besides, it is classified in R36/38 by EU (EC-JRC (ESIS) (Access on June 2011)). |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - |
No data. Besides, it is classified in R36/38 by EU (EC-JRC (ESIS) (Access on June 2011)). |
| 4 | Respiratory sensitization | Classification not possible | - | - | - |
No data. |
| 4 | Skin sensitization | Category 1 |
 |
H317 |
P302+P352 P333+P313 P261 P272 P280 P321 P363 P501 |
It was classified in Category 1 because it is listed as a sensitizing substance in "Contact Dermatitis (Frosch) (4th, 2006)" (corresponding to List 1). Besides, it is reported that an occupational allergic disease was observed in rubber-processing workers due to additives such as this substance. (HSDB (2009)) In addition, it is classified in R43 by EU (EC-JRC (ESIS) (Access on June 2011)). |
| 5 | Germ cell mutagenicity | Not classified | - | - | - |
From a negative result in a chromosomal aberration test using rat bone marrow (in vivo somatic cell mutagenicity test) (ACGIH (2001)), it was classified as "Not classified." Besides, as in vitro tests, negatives in both an Ames test (ACGIH (2001), NTP DB (Access on June 2011)) and a chromosomal aberration test using Chinese hamster lung fibroblasts or CHO cells (NTP DB (Access on June 2011)), and a positive in a gene mutation test using L5178Y mouse lymphoma cells (NTP DB (Access on June 2011)) were reported. |
| 6 | Carcinogenicity | Classification not possible | - | - | - |
It was classified as "Classification not possible" because it is classified in Group 3 by IARC (IARC suppl.7 (1987)) and in A4 by ACGIH (ACGIH (2001)). Besides, in a 2-year diet administration test in rats and mice, evidence of carcinogenicity in male and female rats and male mice was not found, but it was concluded that renal tubular cell adenomas and adenocarcinomas occurred in female mice as rare kidney tumors were equivocal evidence of carcinogenicity. (NTP TR333 (1988)) In addition, it is classified in Carc. 2 in EU. (EC-JRC (ESIS) (Access on June 2011)) |
| 7 | Reproductive toxicity | Classification not possible | - | - | - |
No data. |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - |
Lack of data. Besides, it is reported that venous congestion, and resulting from it, vascular changes in the liver, lung, and brain were observed after oral administration in rats at the dose equal to the LD50 value (8730 mg/kg) (NTP TR333 (1988)), but the further details are unknown. |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - |
In diet administration tests for 13 weeks (2500 to 40000 ppm) or 103 weeks (2500 to 5000 ppm) in rats and mice, a kidney as the primary target organ in both animal species, a dose-dependent increase in nephropathy characterized by renal tubular epithelial degeneration and hyperplasia, and other effects on bone marrow, testis, and thymus were observed, but in a low dose group (2500 ppm [rats: 125 mg/kg/day, mice: 375 mg/kg/day]), any of those changes including the kidney were not observed. (NTP TR333 (1988)) From the dose in the low-dose group above the upper limit of a range of Guidance values (100 mg/kg/day), it corresponds to "Not classified" in an oral route. But there are no or insufficient data in other routes (dermal, inhalation), therefore, it was classified as "Classification not possible" in specific target organ toxicity (repeated exposure). |
| 10 | Aspiration hazard | Classification not possible | - | - | - |
No data. |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 1 |
 |
H400 |
P273 P391 P501 |
It was classified in Category 1 from 48-hour LC50 = 0.30 to 0.68 mg/L for crustacea (Daphnia magna) (CICAD 9, 1998). |
| 11 | Hazardous to the aquatic environment （Long-term） | Category 1 |
|
H410 |
P273 P391 P501 |
If chronic toxicity data are used, then it is classified in Category 1 from lack of rapid degradability (hardly degradable, a degradation rate by BOD: 0 % (the existing chemicals survey program, 2002)), and 21-day NOEC = 0.02 mg/L for crustacea (Daphnia magna) (CICAD 9, 1998). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 1 from lack of rapid degradability (hardly degradable, a degradation rate by BOD: 0 % (the existing chemicals survey program, 2002)), and 96-hour LC50 = 0.44 to 0.74 mg/L for fish (Oncorhynchus mykiss) (CICAD 9, 1998). From the above results, it was classified in Category 1. |
| 12 | Hazardous to the ozone layer | Classification not possible | - | - | - |
This substance is not listed in Annexes to the Montreal Protocol. |
NOTES:
|
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |
Updated date:
|
2017/3/31 Addition of Rationale for the classification |