Item | Information |
---|---|
CAS number | 110-46-3 |
Chemical name | Isopentyl nitrite |
Substance ID | 23A5080 |
Fiscal year of classification conducted | FY2011 |
Classifier(s) (Ministries) | Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE) |
New/Revised | New |
Download in Excel format | Excel file |
Item | Information |
---|---|
Guidance used for classification (External link) |
Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010)
Environmental Hazards: UN GHS Document (4th revised edition) |
Definitions / Abbreviations (Excel file) | Definitions / Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not classified | - | - | - |
It contains a chemical group (N-O) associated with explosive properties, but it is judged not to correspond to superior explosives from 3PGII in UNRTDG (UN1113 pentyl nitrite). Besides, HSDB says that "a stabilizer, such as diphenylamine or epoxolol, is added to the commercially available products." (HSDB (2003)) |
2 | Flammable gases (including chemically unstable gases) | Not applicable | - | - | - | It is a liquid at normal temperatures (Merck (14th, 2006)). |
3 | Aerosols | Not applicable | - | - | - | Not an aerosol product. |
4 | Oxidizing gases | Not applicable | - | - | - | It is a liquid at normal temperatures (Merck (14th, 2006)). |
5 | Gases under pressure | Not applicable | - | - | - | It is a liquid at normal temperatures (Merck (14th, 2006)). |
6 | Flammable liquids | Category 2 |
H225 |
P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
A flash point of -20 degrees C [closed cup] (IMDG (2010)) which is < 23 degrees C, and a boiling point of 97 to 99 degrees C (Merck (14th, 2006)) which is > 35 degrees C, correspond to Category 2. | |
7 | Flammable solids | Not applicable | - | - | - | It is a liquid at normal temperatures (Merck (14th, 2006)). |
8 | Self-reactive substances and mixtures | Not classified | - | - | - | It contains a chemical group (N-O) associated with explosive properties, but it is judged not to correspond to a superior self-reactive property from 3PGII in UNRTDG (UN1113 pentyl nitrite). |
9 | Pyrophoric liquids | Not classified | - | - | - | It is conceivable that it does not ignite at normal temperatures from an ignition point of 210 degrees C (Hommel (1996)). |
10 | Pyrophoric solids | Not applicable | - | - | - | It is a liquid at normal temperatures (Merck (14th, 2006)). |
11 | Self-heating substances and mixtures | Classification not possible | - | - | - | No established test method suitable for liquid substances. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Classification not possible | - | - | - | It contains oxygen which is chemically bonded to nitrogen other than carbon or hydrogen, but the classification is not possible due to no data. |
14 | Oxidizing solids | Not applicable | - | - | - | It is a liquid at normal temperatures (Merck (14th, 2006)). |
15 | Organic peroxides | Not applicable | - | - | - | An organic compound that does not contain -O-O- structure. |
16 | Corrosive to metals | Classification not possible | - | - | - | No data. |
Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Classification not possible | - | - | - |
Lack of data. Besides, details of a reported LD50 value of 505 mg/kg for rats (RTECS (2009)) from list 3 are unknown. |
1 | Acute toxicity (Dermal) | Classification not possible | - | - | - | No data. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable | - | - | - | It is a liquid at normal temperatures (Merck (14th, 2006)). |
1 | Acute toxicity (Inhalation: Vapours) | Category 3 |
H331 |
P304+P340 P403+P233 P261 P271 P311 P321 P405 |
On the basis of an LC50 value of 716 ppm/4h for rats (RTECS (2009), original literature; FUNDAMENTAL AND APPLIED TOXICOLOGY 8, 101-106 (1987)) with confirmation of the description in the original literature, it was classified in Category 3. Besides, a reference value of gasses as vapour with hardly included mist was applied because the LC50 value is lower than 90 % of the saturated vapour pressure concentration (4605 ppm). |
|
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible | - | - | - | No data. |
2 | Skin corrosion/irritation | Classification not possible | - | - | - | No data. |
3 | Serious eye damage/eye irritation | Classification not possible | - | - | - |
No data. Besides, there is the information that application of amyl nitrite to normal rabbit eyes caused only slight superficial injury. (HSDB (2003)) |
4 | Respiratory sensitization | Classification not possible | - | - | - | No data. |
4 | Skin sensitization | Classification not possible | - | - | - | No data. |
5 | Germ cell mutagenicity | Classification not possible | - | - | - |
The classification is not possible due to no in vivo test data. Besides, positives in both an Ames test and a chromosomal aberration test using CHO cells are reported respectively in in vitro tests (NTP DB (1981)). |
6 | Carcinogenicity | Classification not possible | - | - | - | No data. |
7 | Reproductive toxicity | Classification not possible | - | - | - | No data. |
8 | Specific target organ toxicity - Single exposure | Category 1 (cardiovascular system, blood system, nervous system) |
H370 |
P307+P311 P260 P264 P270 P321 P405 P501 |
This substance is used as medicines for angina and detoxification in cyanide poisoning. There is the information that administration causes smooth muscle relaxation, peripheral vasodilation and lowering of blood pressure (Ethical pharmaceuticals (2010), corresponding to List 1), and an inhalation exposure of large doses causes symptoms such as flushing of the face, pulsatile headache, cyanosis, weakness, restlessness, and confusion (PATTY (5th, 2001)). It was classified in Category 1 (cardiovascular system, blood system) because methemoglobinemia, cyanosis, and hemolytic anemia are described as serious adverse effects with unknown frequency in the drug package insert (Ethical pharmaceuticals (2010)). It was classified in Category 1 (nervous system) because there is the information that nervous system symptoms such as dizziness, ataxia, syncope, sedative action, a sense of weakness are found by inhalation of nitrite esters in high concentrations in addition to the above symptoms (a meeting material of Committee on Designated Substances, Pharmaceutical Affairs and Food Sanitation Council, MHLW (2006)). |
|
9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | No data. |
10 | Aspiration hazard | Classification not possible | - | - | - | No data. |
Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Classification not possible | - | - | - | No data. |
11 | Hazardous to the aquatic environment (Long-term) | Classification not possible | - | - | - | No data. |
12 | Hazardous to the ozone layer | Classification not possible | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
2016/9/2 Addition of Rationale for the classification |