GHS Classification Result

日本語で表示

GENERAL INFORMATION

Item Information
CAS number 110-46-3
Chemical name Isopentyl nitrite
Substance ID 23A5080
Fiscal year of classification conducted FY2011
Classifier(s) (Ministries) Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
New/Revised New
Download in Excel format Excel file

REFERENCE INFORMATION

Item Information
Guidance used for classification (External link) Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010)
Environmental Hazards: UN GHS Document (4th revised edition)
Definitions / Abbreviations (Excel file) Definitions / Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS

Hazard class Classification Pictogram
(Code: symbol)
Signal word
Code
(Hazard statement)
Code
(Precautionary statement)
Rationale for the classification
1 Explosives Not classified - - - It contains a chemical group (N-O) associated with explosive properties, but it is judged not to correspond to superior explosives from 3PGII in UNRTDG (UN1113 pentyl nitrite).
Besides, HSDB says that "a stabilizer, such as diphenylamine or epoxolol, is added to the commercially available products." (HSDB (2003))
2 Flammable gases (including chemically unstable gases) Not applicable - - - It is a liquid at normal temperatures (Merck (14th, 2006)).
3 Aerosols Not applicable - - - Not an aerosol product.
4 Oxidizing gases Not applicable - - - It is a liquid at normal temperatures (Merck (14th, 2006)).
5 Gases under pressure Not applicable - - - It is a liquid at normal temperatures (Merck (14th, 2006)).
6 Flammable liquids Category 2

Danger
H225
P303+P361+P353
P370+P378
P403+P235
P210
P233
P240
P241
P242
P243
P280
P501
A flash point of -20 degrees C [closed cup] (IMDG (2010)) which is < 23 degrees C, and a boiling point of 97 to 99 degrees C (Merck (14th, 2006)) which is > 35 degrees C, correspond to Category 2.
7 Flammable solids Not applicable - - - It is a liquid at normal temperatures (Merck (14th, 2006)).
8 Self-reactive substances and mixtures Not classified - - - It contains a chemical group (N-O) associated with explosive properties, but it is judged not to correspond to a superior self-reactive property from 3PGII in UNRTDG (UN1113 pentyl nitrite).
9 Pyrophoric liquids Not classified - - - It is conceivable that it does not ignite at normal temperatures from an ignition point of 210 degrees C (Hommel (1996)).
10 Pyrophoric solids Not applicable - - - It is a liquid at normal temperatures (Merck (14th, 2006)).
11 Self-heating substances and mixtures Classification not possible - - - No established test method suitable for liquid substances.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Classification not possible - - - It contains oxygen which is chemically bonded to nitrogen other than carbon or hydrogen, but the classification is not possible due to no data.
14 Oxidizing solids Not applicable - - - It is a liquid at normal temperatures (Merck (14th, 2006)).
15 Organic peroxides Not applicable - - - An organic compound that does not contain -O-O- structure.
16 Corrosive to metals Classification not possible - - - No data.

HEALTH HAZARDS

Hazard class Classification Pictogram
(Code: symbol)
Signal word
Code
(Hazard statement)
Code
(Precautionary statement)
Rationale for the classification
1 Acute toxicity (Oral) Classification not possible - - - Lack of data.
Besides, details of a reported LD50 value of 505 mg/kg for rats (RTECS (2009)) from list 3 are unknown.
1 Acute toxicity (Dermal) Classification not possible - - - No data.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - It is a liquid at normal temperatures (Merck (14th, 2006)).
1 Acute toxicity (Inhalation: Vapours) Category 3

Danger
H331
P304+P340
P403+P233
P261
P271
P311
P321
P405
On the basis of an LC50 value of 716 ppm/4h for rats (RTECS (2009), original literature; FUNDAMENTAL AND APPLIED TOXICOLOGY 8, 101-106 (1987)) with confirmation of the description in the original literature, it was classified in Category 3.
Besides, a reference value of gasses as vapour with hardly included mist was applied because the LC50 value is lower than 90 % of the saturated vapour pressure concentration (4605 ppm).
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - No data.
2 Skin corrosion/irritation Classification not possible - - - No data.
3 Serious eye damage/eye irritation Classification not possible - - - No data.
Besides, there is the information that application of amyl nitrite to normal rabbit eyes caused only slight superficial injury. (HSDB (2003))
4 Respiratory sensitization Classification not possible - - - No data.
4 Skin sensitization Classification not possible - - - No data.
5 Germ cell mutagenicity Classification not possible - - - The classification is not possible due to no in vivo test data.
Besides, positives in both an Ames test and a chromosomal aberration test using CHO cells are reported respectively in in vitro tests (NTP DB (1981)).
6 Carcinogenicity Classification not possible - - - No data.
7 Reproductive toxicity Classification not possible - - - No data.
8 Specific target organ toxicity - Single exposure Category 1 (cardiovascular system, blood system, nervous system)

Danger
H370
P307+P311
P260
P264
P270
P321
P405
P501
This substance is used as medicines for angina and detoxification in cyanide poisoning.
There is the information that administration causes smooth muscle relaxation, peripheral vasodilation and lowering of blood pressure (Ethical pharmaceuticals (2010), corresponding to List 1), and an inhalation exposure of large doses causes symptoms such as flushing of the face, pulsatile headache, cyanosis, weakness, restlessness, and confusion (PATTY (5th, 2001)).
It was classified in Category 1 (cardiovascular system, blood system) because methemoglobinemia, cyanosis, and hemolytic anemia are described as serious adverse effects with unknown frequency in the drug package insert (Ethical pharmaceuticals (2010)).
It was classified in Category 1 (nervous system) because there is the information that nervous system symptoms such as dizziness, ataxia, syncope, sedative action, a sense of weakness are found by inhalation of nitrite esters in high concentrations in addition to the above symptoms (a meeting material of Committee on Designated Substances, Pharmaceutical Affairs and Food Sanitation Council, MHLW (2006)).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - No data.
10 Aspiration hazard Classification not possible - - - No data.

ENVIRONMENTAL HAZARDS

Hazard class Classification Pictogram
(Code: symbol)
Signal word
Code
(Hazard statement)
Code
(Precautionary statement)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - No data.
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - No data.
12 Hazardous to the ozone layer Classification not possible - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTES:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
   and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.



Updated date:
2016/9/2 Addition of Rationale for the classification

List of GHS Classification Results