GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTES:
Updated date:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS number | 107-14-2 |
| Chemical name | Chloroacetonitrile |
| Substance ID | 23A5079 |
| Fiscal year of classification conducted | FY2011 |
| Classifier(s) (Ministries) | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| New/Revised | New |
| Download in Excel format | Excel file |
| Item | Information |
|---|---|
| Guidance used for classification (External link) |
Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government （July, 2010）
Environmental Hazards: UN GHS Document （4th revised edition） |
| Definitions / Abbreviations (Excel file) | Definitions / Abbreviations |
| Model Label by MHLW (External link) | MHLW Website （in Japanese Only） |
| Model SDS by MHLW (External link) | MHLW Website （in Japanese Only） |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | It is a liquid at normal temperatures (Ullmanns (E) (6th, 2003)). |
| 3 | Aerosols | Not applicable | - | - | - | Not an aerosol product. |
| 4 | Oxidizing gases | Not applicable | - | - | - | It is a liquid at normal temperatures (Ullmanns (E) (6th, 2003)). |
| 5 | Gases under pressure | Not applicable | - | - | - | It is a liquid at normal temperatures (Ullmanns (E) (6th, 2003)). |
| 6 | Flammable liquids | Category 3 |  |
H226 |
P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
A flash point of 56 degrees C [closed-cup] (IMDG (2010), which is >= 23 degrees C and <= 60 degrees C, corresponds to Category 3. |
| 7 | Flammable solids | Not applicable | - | - | - | It is a liquid at normal temperatures (Ullmanns (E) (6th, 2003)). |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Classification not possible | - | - | - | No data. |
| 10 | Pyrophoric solids | Not applicable | - | - | - | It is a liquid at normal temperatures (Ullmanns (E) (6th, 2003)). |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | No established test method suitable for liquid substances. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | An organic compound that contains chlorine which is not chemically bonded to elements other than carbon. |
| 14 | Oxidizing solids | Not applicable | - | - | - | It is a liquid at normal temperatures (Ullmanns (E) (6th, 2003)). |
| 15 | Organic peroxides | Not applicable | - | - | - | An organic compound that does not contain -O-O- structure. |
| 16 | Corrosive to metals | Classification not possible | - | - | - | No data. |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 3 |  |
H301 |
P301+P310 P264 P270 P321 P330 P405 P501 |
On the basis of an LD50 value of 152.8 mg/kg bw for rats (EHC 216 (2000)), it was classified in Category 3. |
| 1 | Acute toxicity （Dermal） | Category 2 | |
H310 |
P302+P350 P262 P264 P270 P280 P310 P322 P361 P363 P405 P501 |
On the basis of an LD50 value of 0.071 mL/kg (84.4 mg/kg) for rabbits (RTECS (2008), original literature; American Industrial Hygiene Association Journal. Vol. 23, Pg. 95, 1962.), it was classified in Category 2. Besides, it is classified in T; R24 in EU classification (EC-JRC (ESIS) (Access on June. 2011)). |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | It is a liquid at normal temperatures (Ullmanns (E) (6th, 2003)). |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - |
Lack of data. Besides, RTECS reported that 250 ppm exposure (vapour) to rats caused 1 death in 6 animals and resulted in an LCLo value of 250 ppm (0.772 mg/L) (RTECS (2008), original literature; American Industrial Hygiene Association Journal. Vol. 23, Pg. 95, 1962.). And it is classified in T; R23 in EU classification. (EC-JRC (ESIS) (Access on June. 2011)) |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | No data. |
| 2 | Skin corrosion/irritation | Not classified | - | - | - | On the basis that 24-hour open application of 0.01 mL undiluted this substance to rabbits which showed only slight congestion in blood capillary (RTECS (2008), original literature; American Industrial Hygiene Association Journal. Vol. 23, Pg. 95, 1962.) rated as Grade 2 (mild irritant) on a scale of 1 to 10, it was classified as "Not classified" in JIS classification (Category 3 in UN GHS classification). |
| 3 | Serious eye damage/eye irritation | Category 2 |  |
H319 |
P305+P351+P338 P337+P313 P264 P280 |
The degree of injury observed 24 hours after application to rabbits was rated as 5 (the most severe injuries are rated 10) on a scale of 1 to 10 (HSDB (2003)), but it was classified in Category 2 without sub-categorization due to unknown details on a recovery period and so on. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | No data. |
| 4 | Skin sensitization | Classification not possible | - | - | - | No data. |
| 5 | Germ cell mutagenicity | Not classified | - | - | - |
On the basis of a negative in a micronucleus test using mouse bone marrow (in vivo somatic cell mutagenicity test) (IARC 52 (1991)), it was classified as "Not classified." Besides, a negative in an Ames test in an in vitro test was reported (NTP DB Study (1981), IARC 52 (1991)). |
| 6 | Carcinogenicity | Classification not possible | - | - | - |
From Group 3 classification in an IARC carcinogenicity evaluation, it was classified as "Classification not possible." Besides, a test observed 10-week-old A/J mice until the age of 9 months after 3-time oral administration in a week for 8 weeks reported a slightly increased incidence of animals with lung tumors. (IARC 52 (1991)) |
| 7 | Reproductive toxicity | Classification not possible | - | - | - |
A 55 mg/kg/day oral administration screening test in rats on day 7 to 21 of gestation reported significant decreased maternal weight gains, but no effects on pregnancy, a proportion of resorptions, pup survival or growth (IARC 52 (1991)). But it was classified as "Classification not possible" due to lack of data because effects on sexual function and fertility by exposures prior to mating are unknown. |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - | No data. |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | No data. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | No data. |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 2 | - |
H401 |
P273 P501 |
It was classified in Category 2 from 96-hour LC50 = 1.35mg/L for fish (Pimephales promelas) (AQUIRE, 2012). |
| 11 | Hazardous to the aquatic environment （Long-term） | Category 2 |  |
H411 |
P273 P391 P501 |
Reliable chronic toxicity data are not obtained. Due to no obtaining appropriate data on rapid degradability and acute toxicity Category 2, it was classified in Category 2. |
| 12 | Hazardous to the ozone layer | Classification not possible | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
NOTES:
|
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Updated date:
|
2016/9/2 Addition of Rationale for the classification |