GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTES:
Updated date:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS number | 105-48-6 |
| Chemical name | Isopropyl chloroacetate |
| Substance ID | 23A5076 |
| Fiscal year of classification conducted | FY2011 |
| Classifier(s) (Ministries) | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| New/Revised | New |
| Download in Excel format | Excel file |
| Item | Information |
|---|---|
| Guidance used for classification (External link) |
Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government （July, 2010）
Environmental Hazards: UN GHS Document （4th revised edition） |
| Definitions / Abbreviations (Excel file) | Definitions / Abbreviations |
| Model Label by MHLW (External link) | MHLW Website （in Japanese Only） |
| Model SDS by MHLW (External link) | MHLW Website （in Japanese Only） |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Symbol Signal word |
Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | It is a liquid at normal temperatures (HSDB (2003)). |
| 3 | Aerosols | Not applicable | - | - | - | Not an aerosol product. |
| 4 | Oxidizing gases | Not applicable | - | - | - | It is a liquid at normal temperatures (HSDB (2003)). |
| 5 | Gases under pressure | Not applicable | - | - | - | It is a liquid at normal temperatures (HSDB (2003)). |
| 6 | Flammable liquids | Category 3 |  |
H226 |
P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
A flash point of 56 degrees C [closed-cup] (IUCLID (2000)) is >= 23 degrees C and <= 60 degrees C, therefore it corresponds to Category 3. Besides, it is classified in Class3PGIII in UNRTDG (UN2947). |
| 7 | Flammable solids | Not applicable | - | - | - | It is a liquid at normal temperatures (HSDB (2003)). |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | Containing neither chemical groups related to explosibility nor those related to self-reactivity. |
| 9 | Pyrophoric liquids | Not classified | - | - | - | It is conceivable that it does not ignite at normal temperatures from an ignition point of 415 degrees C (IUCLID (2000)). |
| 10 | Pyrophoric solids | Not applicable | - | - | - | It is a liquid at normal temperatures (HSDB (2003)). |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | No established test method suitable for liquid substances. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | An organic compound does not contain fluorine but contains oxygen and chlorine, and these elements are not chemically bonded to elements other than carbon. |
| 14 | Oxidizing solids | Not applicable | - | - | - | It is a liquid at normal temperatures (HSDB (2003)). |
| 15 | Organic peroxides | Not applicable | - | - | - | An organic compound that does not contain -O-O- structure. |
| 16 | Corrosive to metals | Classification not possible | - | - | - | No data. |
| Hazard class | Classification |
Symbol Signal word |
Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 2 |  |
H300 |
P301+P310 P264 P270 P321 P330 P405 P501 |
A reported LD50 value of <= 50 mg/kg for rats [Directive 84/449/EEC, B.1; GLP] (IUCLID (2000)) corresponds to Category 1 or Category 2, but it was classified in Category 2 by taking R25 in EU Classification (EC-JRC (ESIS) (Access on June. 2011)) into consideration. |
| 1 | Acute toxicity （Dermal） | Not classified | - | - | - | On the basis of an LD50 value of > 2000 mg/kg for rats [Directive 92/69/EEC, B.3; GLP] (IUCLID (2000)), it was classified as "Not classified" in Classification JIS (corresponding to Category 5 or "not classified" in UN GHS classification). |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | It is a liquid at normal temperatures (HSDB (2003)). |
| 1 | Acute toxicity （Inhalation: Vapours） | Category 3 | |
H331 |
P304+P340 P403+P233 P261 P271 P311 P321 P405 |
It was classified in Category 3 base on an LC50 value of 859 ppm/4h for rats [Directive 84/449/EEC, B.2; GLP] (IUCLID (2000)). Besides, a reference value of gasses as a vapour with hardly included mist was applied because the LC50 value (859 ppm) is lower than 90 % of the saturated vapour pressure concentration (5395 ppm). |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | No data. |
| 2 | Skin corrosion/irritation | Not classified | - | - | - | On the basis of a result as "not irritating" in a test using rats (Directive 84/449/EEC, B.4, GLP) (IUCLID (2000)), it was classified as "Not classified." |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | No data. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | No data. |
| 4 | Skin sensitization | Classification not possible | - | - | - | No data. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - |
The classification is not possible due to no in vivo test data. Besides, as in vitro tests, an Ames test using salmonella reports a negative, but a test using Escherichia coli without metabolic activation results in a partially slightly positive (IUCLID (2000)). |
| 6 | Carcinogenicity | Classification not possible | - | - | - | No data. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | No data. |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - | No data. |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | No data. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | No data. |
| Hazard class | Classification |
Symbol Signal word |
Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | No data. |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | No data. |
| 12 | Hazardous to the ozone layer | Classification not possible | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
NOTES:
|
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Updated date:
|
2016/6/29 Addition of Rationale for the classification |