GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTES:
Updated date:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS number | 56425-91-3 |
| Chemical name | Flurprimidol |
| Substance ID | 23A5064 |
| Fiscal year of classification conducted | FY2011 |
|
Classifier(s) (Ministries) |
Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| New/Revised | New |
| Download in Excel format | Excel file |
| Item | Information |
|---|---|
|
Guidance used for classification (External link) |
Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document （4th revised edition） |
|
Definitions / Abbreviations (Excel file) |
Definitions / Abbreviations |
|
Model Label by MHLW (External link) |
MHLW Website （in Japanese Only） |
|
Model SDS by MHLW (External link) |
MHLW Website （in Japanese Only） |
|
OECD/eChemPortal (External link) |
eChemPortal |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - |
There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - |
"Solids" according to GHS definition. |
| 3 | Aerosols | Not applicable | - | - | - |
Not an aerosol product. |
| 4 | Oxidizing gases | Not applicable | - | - | - |
"Solids" according to GHS definition. |
| 5 | Gases under pressure | Not applicable | - | - | - |
"Solids" according to GHS definition. |
| 6 | Flammable liquids | Not applicable | - | - | - |
"Solids" according to GHS definition. |
| 7 | Flammable solids | Classification not possible | - | - | - |
No data. |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - |
There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not applicable | - | - | - |
"Solids" according to GHS definition. |
| 10 | Pyrophoric solids | Classification not possible | - | - | - |
No data. |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | No established test method suitable for solid substances with a melting point of 140 degrees C or lower. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - |
Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - |
"Solids" according to GHS definition. |
| 14 | Oxidizing solids | Not applicable | - | - | - |
An organic compound that contains oxygen and fluorine which are not chemically bonded to elements other than carbon or hydrogen. |
| 15 | Organic peroxides | Not applicable | - | - | - |
An organic compound that does not contain -O-O- structure. |
| 16 | Corrosive to metals | Classification not possible | - | - | - |
No established test method suitable for solid substances. |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 4 |
 |
H302 |
P301+P312 P264 P270 P330 P501 |
From two LD50 values for rats (males 1413 mg/kg, females 1875 mg/kg) (Agricultural chemicals times supplement "Agricultural chemicals technology information" No. 18 (1995), corresponding to List 2), it was classified in Category 4. |
| 1 | Acute toxicity （Dermal） | Not classified | - | - | - |
From an LD50 value of >5000 mg/kg for rats (Agricultural chemicals times supplement "Agricultural chemicals technology information" No. 18 (1995)), it was classified as "Not classified." |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - |
"Solids" according to GHS definition. |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - |
No data. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Category 4 |
|
H332 |
P304+P340 P261 P271 P312 |
From an LC50 value of 1.1 mg/L/4 for rats (RTECS (2003): original literature; National Technical Information Service OTS0536993), it was classified in Category 4. Besides, an LC50 value of > 5.231 mg/L for rats whose exposure duration was unknown was described in another test. (Agricultural chemicals times supplement "Agricultural chemicals technology information" No. 18 (1995)) Furthermore, it was considered to be a test by dust because the LC50 value was higher than the saturated vapour pressure concentration (4.21E-06 mg/L). |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - |
It was assessed as slightly irritating from erythema in all animals and edema in 4 animals after application of a 50% preparation to 6 rabbits. (Agricultural chemicals times supplement "Agricultural chemicals technology information" No. 18 (1995)) But the test, details of which such as exposure duration, skin reaction intensity and duration were unknown, was conducted on the 50% preparation, therefore, it was classified as "Classification not possible" due to lack of data. |
| 3 | Serious eye damage/eye irritation | Category 2B |
|
H320 |
P305+P351+P338 P337+P313 P264 |
It was assessed as slightly irritating because irritating changes in cornea and conjunctiva in all animals and irritating changes in the iris in two animals observed after application of a 50% preparation of this substance in three rabbits reversed within 48 hours after application. (Agricultural chemicals times supplement "Agricultural chemicals technology information" No. 18 (1995)). Therefore, it was classified in Category 2B. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - |
No data. |
| 4 | Skin sensitization | Classification not possible | - | - | - |
It was reported that this substance was negative sensitizing in a Buehler test in guinea pigs on a 50% preparation. (Agricultural chemicals times supplement "Agricultural chemicals technology information" No. 18 (1995)) But it was classified as "Classification not possible" due to data from List 2 and unknown sensitized animal ratio. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - |
The classification is not possible due to no in vivo test data. Besides, both an Ames test and a chromosomal aberration test using Chinese hamster ovary cells reported negatives as in vitro tests. (Agricultural chemicals times supplement "Agricultural chemicals technology information" No. 18 (1995)) |
| 6 | Carcinogenicity | Classification not possible | - | - | - |
Lack of data. Besides, a 2-year diet administration test using rats and mice did not mention carcinogenicity. (IRIS (2002)) Furthermore, quoting from IRIS, it is remarked that "this substance/agent has not undergone a complete evaluation and determination under US EPA's IRIS program for evidence of human carcinogenic potential." (IRIS (2002)) |
| 7 | Reproductive toxicity | Category 2 |
 |
H361 |
P308+P313 P201 P202 P281 P405 P501 |
In a two-generation reproductive toxicity test by diet administration prior to mating in male and female rats, hepatocellular vacuolization and hypertrophy at 100 ppm (7.3 mg/kg/day) or higher in parent animals as general toxicity, decreased fertility and decreased survival in gestation with a decrease in litter size through two generations, changes in sex cycle accompanied by prolonged estrus, and decreased neonatal survival at the highest concentration of 1000 ppm (74 mg/kg/day) were also observed. (IRIS (2002)) Therefore it was classified in Category 2. Besides, in a developmental toxicity test by oral administration in an organogenetic period in rats or rabbits, adverse effects on the development of the offspring including teratogenicity were not reported. (IRIS (2002)) |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - |
No data. |
| 9 | Specific target organ toxicity - Repeated exposure |
Category 2 (liver, adrenal gland) |
|
H373 |
P260 P314 P501 |
In a 3-month diet administration test in mice, dose-dependent elevated alkaline phosphatase and centrilobular hypertrophy of hepatocytes were observed at doses of 450 ppm (67.5 mg/kg/day) or higher. (Agricultural chemicals times supplement "Agricultural chemicals technology information" No. 18 (1995)) In a 2-year diet administration test in rats, increased cholesterol and triglycerides, fatty changes in livers, and eosinophilic changes of hepatocytes were observed at 1000 ppm (41.2 mg/kg/day). (IRIS (2002)) Because these doses corresponded to Category 2 in Guidance values, it was classified in Category 2 (liver). On the other hand, in a 90-day or 1-year diet administration test in dogs, degeneration in zona fasciculata and zona reticularis of adrenal cortex characterized by eosinophilic degeneration, vacuolation and cortical atrophy in animals at doses of 30 mg/kg/day or higher were reported as histopathological signs. (IRIS (2002)) Because the doses corresponded to Category 2 in Guidance values, it was classified in Category 2 (adrenal gland). |
| 10 | Aspiration hazard | Classification not possible | - | - | - |
No data. |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 3 | No pictogram |
H402 |
P273 P501 |
It was classified in Category 3 from 48-hour EC50 = 11.8 mg/L for crustacea (Daphnia magna) (AQUIRE, 2012). |
| 11 | Hazardous to the aquatic environment （Long-term） | Category 3 | No pictogram |
H412 |
P273 P501 |
Reliable chronic toxicity data were not obtained. Due to lack of rapid degradability (BIOWIN), and acute toxicity Category 3, it was classified in Category 3. |
| 12 | Hazardous to the ozone layer | Classification not possible | - | - | - |
This substance is not listed in Annexes to the Montreal Protocol. |
NOTES:
|
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Updated date:
|
2017/3/17 Addition of Rationale for the classification |