GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTES:
Updated date:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS number | 446-35-5 |
| Chemical name | 2,4-Difluoro-1-nitrobenzene |
| Substance ID | 23A5062 |
| Fiscal year of classification conducted | FY2011 |
|
Classifier(s) (Ministries) |
Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| New/Revised | New |
| Download in Excel format | Excel file |
| Item | Information |
|---|---|
|
Guidance used for classification (External link) |
Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document （4th revised edition） |
|
Definitions / Abbreviations (Excel file) |
Definitions / Abbreviations |
|
Model Label by MHLW (External link) |
MHLW Website （in Japanese Only） |
|
Model SDS by MHLW (External link) |
MHLW Website （in Japanese Only） |
|
OECD/eChemPortal (External link) |
eChemPortal |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Classification not possible | - | - | - |
It contains a chemical group associated with an explosive property (a nitro group), but the classification is not possible due to no data based on a prescribed test method. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - |
"Liquids" according to GHS definition. |
| 3 | Aerosols | Not applicable | - | - | - |
Not an aerosol product. |
| 4 | Oxidizing gases | Not applicable | - | - | - |
"Liquids" according to GHS definition. |
| 5 | Gases under pressure | Not applicable | - | - | - |
"Liquids" according to GHS definition. |
| 6 | Flammable liquids | Category 4 |
|
H227 |
P370+P378 P403+P235 P210 P280 P501 |
A flash point of 91 degrees C [closed cup] (MSDS (Sigma-Aldrich)), which is > 60 degrees C and <= 93 degrees C, corresponds to Category 4. |
| 7 | Flammable solids | Not applicable | - | - | - |
"Liquids" according to GHS definition. |
| 8 | Self-reactive substances and mixtures | Classification not possible | - | - | - |
It contains a chemical group associated with an explosive property (a nitro group), but the classification is not possible due to no data based on a prescribed test method. |
| 9 | Pyrophoric liquids | Not classified | - | - | - |
It is conceivable that it does not ignite at normal temperatures from an ignition point of 480 degrees C (BUA 252 (2004)). |
| 10 | Pyrophoric solids | Not applicable | - | - | - |
"Liquids" according to GHS definition. |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - |
No established test method suitable for liquid substances. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - |
Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Classification not possible | - | - | - |
An organic compound that contains oxygen which is chemically bonded to an element other than carbon or hydrogen (N), but the classification is not possible due to no data. Besides, fluorine covalently bonded to the carbon which is contained does not contribute to the oxidation of other substances. |
| 14 | Oxidizing solids | Not applicable | - | - | - |
"Liquids" according to GHS definition. |
| 15 | Organic peroxides | Not applicable | - | - | - |
An organic compound that does not contain -O-O- structure. |
| 16 | Corrosive to metals | Classification not possible | - | - | - |
No data. |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 3 |
 |
H301 |
P301+P310 P264 P270 P321 P330 P405 P501 |
From LD50 values of 200 mg/kg and 194 mg/kg for rats (BUA Report 252 (2004)), it was classified in Category 3. |
| 1 | Acute toxicity （Dermal） | Category 2 |
|
H310 |
P302+P350 P262 P264 P270 P280 P310 P322 P361 P363 P405 P501 |
An LD50 value of 84 mg/kg for rats (BUA Report 252 (2004)) corresponds to Category 2, and an LD50 value of 207 mg/kg for rabbits (BUA Report 252 (2004)) corresponds to Category 3. It was classified in Category 2 by adopting higher hazard category. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - |
"Liquids" according to GHS definition. |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - |
Because the LC50 above 274 ppm/8h = 387 ppm/4h from no deaths as a result of 8-hour exposure of > 1.78 mg/L (274 ppm) to rats (BUA Report 252 (2004)) cannot determine the category, the classification is not possible. Besides, a reference value of gasses as vapour with hardly included mist was applied because the test concentration (1.78 mg/L) is lower than 90 % of the saturated vapour pressure concentration (2.17 mg/L). |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - |
No data. |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - |
It was reported that this substance which has the difficulty of long-time application due to the high dermal toxicity causing deaths in animals, was washed off 15 minutes after application of 1 ml undiluted solution, then non-irritant was observed. (BUA Report 252 (2004)) But it was classified as "Classification not possible" due to an insufficient test method. |
| 3 | Serious eye damage/eye irritation | Not classified | - | - | - |
In a test applied 0.1 mL of the undiluted test substance to conjunctival sac of 6 rabbits (OECD TG 405; GLP), no effects on cornea and iris, redness of score 2 and edema of score 1 in conjunctiva 1 hour after application in all animals all of which reversed after two days, and an irritation score MMAS (equivalent to AOI, maximum 110) of 1.7 were observed. (ECETOC 48 (2) (1998)) Therefore it was classified as "Not classified." Besides, in another similar test using rabbits, "slightly irritating" from irritation scores of 5, 2, 14, 10 and 11 (maximum 110) after 1, 7, 24, 48 and 72 hours respectively, all of which were not more than 15 was reported. (BUA Report 252 (2004)) |
| 4 | Respiratory sensitization | Classification not possible | - | - | - |
No data. |
| 4 | Skin sensitization | Classification not possible | - | - | - |
As a result of treatment of provocation in 30 humans whose skin reaction disappeared after induction in an application of this substance to 96 volunteers to investigate a delayed hypersensitivity skin reaction, a positive reaction in 27 humans (90%) was reported. (BUA Report 252 (2004)) But it was classified as "Classification not possible" because data are from List 2, the details are unknown including a result in a control group, and it was not concluded from this result that this substance was positive. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - |
The classification is not possible due to no in vivo test data. Besides, as an in vitro test, an Ames test reported a positive. (BUA Report 252 (2004)) |
| 6 | Carcinogenicity | Classification not possible | - | - | - |
No data. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - |
No data. |
| 8 | Specific target organ toxicity - Single exposure |
Category 2 (blood) |
 |
H371 |
P309+P311 P260 P264 P270 P405 P501 |
The attribution of the methemoglobin formation caused by this substance to the reduction of a nitro group was described as a mechanism of action for this substance, (BUA Report 252 (2004)) It was reported that cats showed 8.5 to 11.4% of methemoglobin formation and 11 to 14% of Heinz body formation after an oral administration of 100 mg/kg, indicated muscular tremor, reflex, increased salivation, and panting, then died within 2 hours. (BUA Report 252 (2004)) The methemoglobin formation shown in rats also, which indicated the maximal concentration of 6% after 1 hour of oral administration at 80 mg/kg and decreased to not more than 2% after 48 hours, was described. (BUA Report 252 (2004)) From the above knowledge, it corresponds to Category 1 judging from Guidance values by adopting blood as a target organ. But it was classified in Category 2 (blood) in accordance with Guidance because data are from List 2 and do not meet Decision Criteria 1b3). |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - |
No data. |
| 10 | Aspiration hazard | Classification not possible | - | - | - |
No data. |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 2 | No pictogram |
H401 |
P273 P501 |
It was classified in Category 2 from 96-hour LC50 = 7.1 mg/L for fish (Danio rerio) (BUA 252, 2004). |
| 11 | Hazardous to the aquatic environment （Long-term） | Category 2 |
 |
H411 |
P273 P391 P501 |
Reliable chronic toxicity data were not obtained. Due to lack of rapid degradability (BIOWIN), and acute toxicity Category 2, it was classified in Category 2. |
| 12 | Hazardous to the ozone layer | Classification not possible | - | - | - |
This substance is not listed in Annexes to the Montreal Protocol. |
NOTES:
|
* A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Updated date:
|
2017/3/17 Addition of Rationale for the classification |