Item | Information |
---|---|
CAS number | 366-18-7 |
Chemical name | 2,2'-Bipyridyl |
Substance ID | 23A5061 |
Fiscal year of classification conducted | FY2011 |
Classifier(s) (Ministries) | Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE) |
New/Revised | New |
Download in Excel format | Excel file |
Item | Information |
---|---|
Guidance used for classification (External link) |
Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010)
Environmental Hazards: UN GHS Document (4th revised edition) |
Definitions / Abbreviations (Excel file) | Definitions / Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable | - | - | - | There are no chemical groups associated with explosive properties present in the molecule. |
2 | Flammable gases (including chemically unstable gases) | Not applicable | - | - | - | "Solids" according to GHS definition. |
3 | Aerosols | Not applicable | - | - | - | Not an aerosol product. |
4 | Oxidizing gases | Not applicable | - | - | - | "Solids" according to GHS definition. |
5 | Gases under pressure | Not applicable | - | - | - | "Solids" according to GHS definition. |
6 | Flammable liquids | Not applicable | - | - | - | "Solids" according to GHS definition. |
7 | Flammable solids | Classification not possible | - | - | - | No data. |
8 | Self-reactive substances and mixtures | Not applicable | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
9 | Pyrophoric liquids | Not applicable | - | - | - | "Solids" according to GHS definition. |
10 | Pyrophoric solids | Classification not possible | - | - | - | No data. |
11 | Self-heating substances and mixtures | Classification not possible | - | - | - | No established test method suitable for solid substances with a melting point of 140 degrees C or lower. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable | - | - | - | "Solids" according to GHS definition. |
14 | Oxidizing solids | Not applicable | - | - | - | An organic compound that does not contain oxygen, fluorine, or chlorine. |
15 | Organic peroxides | Not applicable | - | - | - | An organic compound that does not contain -O-O- structure. |
16 | Corrosive to metals | Classification not possible | - | - | - | No established test method suitable for solid substances. |
Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 3 |
H301 |
P301+P310 P264 P270 P321 P330 P405 P501 |
All of 4 LD50 values for rats (107 mg/kg, 100 mg/kg, 256 mg/kg, 250 mg/kg) (IUCLID (2000)) correspond to Category 3. | |
1 | Acute toxicity (Dermal) | Category 3 |
H311 |
P302+P352 P280 P312 P322 P361 P363 P405 P501 |
It was classified in Category 3 that was the majority of possible categories to which 4 LD50 values for rats (>400 mg/kg, 250 to 600 mg/kg, 400 to 1000 mg/kg, 625 to 1250 mg/kg) (IUCLID (2000)) correspond. | |
1 | Acute toxicity (Inhalation: Gases) | Not applicable | - | - | - | "Liquids" according to GHS definition. |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible | - | - | - | No data. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible | - | - | - | No data. |
2 | Skin corrosion/irritation | Not classified | - | - | - | On the basis that 2 tests using rats reported "slightly irritating" (IUCLID (2000)), it was classified as "Not classified" in JIS classification (Category 3 in UN GHS classification). |
3 | Serious eye damage/eye irritation | Category 2 |
H319 |
P305+P351+P338 P337+P313 P264 P280 |
A test using rabbits resulted in not irritating while another test reported moderately irritating with an unknown recovery period (IUCLID (2000)). It was classified in Category 2 without sub-categorization by taking the information that pyridine and its derivatives cause local irritation on contact with the skin, mucous membrane and cornea (HSDB (2000)) into consideration and due to no description of the recovery period in the rabbit test. |
|
4 | Respiratory sensitization | Classification not possible | - | - | - | No data. |
4 | Skin sensitization | Classification not possible | - | - | - | Because a Draize test using guinea pigs, which reported not sensitizing (IUCLID (2000)), was not a test method agreed by OECD and from List 2 data, it was classified as "Classification not possible." |
5 | Germ cell mutagenicity | Classification not possible | - | - | - |
The classification is not possible due to no in vivo test data. Besides, an Ames test as an in vitro test reported a negative or a positive. (IUCLID (2000)) |
6 | Carcinogenicity | Classification not possible | - | - | - |
Lack of data. Besides, IUCLID reported that 12 survived out of 20 mice and a mouse developed a parotid tumor by 40 times a week subcutaneous injections in 10 months. (IUCLID (2000)) |
7 | Reproductive toxicity | Classification not possible | - | - | - |
Lack of data. Besides, IUCLID reported that intraperitoneal administration of 60 to 75 mg/kg on gestation day 12.5 showed teratogenicity in limb bud development, and also reported that subcutaneous administration on gestation day 12.5 showed embryo absorption in 44% and external malformations in forelimb fingers in 88%. (IUCLID (2000)) |
8 | Specific target organ toxicity - Single exposure | Category 2 (nervous system) |
H371 |
P309+P311 P260 P264 P270 P405 P501 |
From reports of behavioral suppression and loss of coordination in muscles after oral administration in rats (LD50: 100 mg/kg) (IUCLID (2000)) and tremor and slight ptosis after administration of 50 to 250 mg/kg (HSDB (2000)), it was classified in Category 2 (nervous system). Besides, they correspond to Category 1 by judging from Guidance values, but it was classified in Category 2 in accordance with the Guidance because they are from List 2 and do not meet Decision Criteria 1b3) (OECD TG and GLP). |
|
9 | Specific target organ toxicity - Repeated exposure | Category 2 (kidney) |
H373 |
P260 P314 P501 |
A 90-day drinking water administration test (7, 13, 35.6 mg/kg/day) reported that some animals showed changes in the kidney that are calcium stone and nephrosclerosis and in some cases hypertrophy of Bowman's glomerular capsule and brown pigmentation in the renal tubular epithelium (IUCLID (2000)). Due to data from List 2, it was classified in Category 2 (kidney), although it is unknown whether the effects were observed at a dose of the range of Category 1 in Guidance values. Besides, no adverse effects were reported in a 28-day oral administration test in dogs at 10 to 40 mg/kg/day except occasional vomiting (IUCLID (2000)). |
|
10 | Aspiration hazard | Classification not possible | - | - | - | No data. |
Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Classification not possible | - | - | - | No data. |
11 | Hazardous to the aquatic environment (Long-term) | Classification not possible | - | - | - | No data. |
12 | Hazardous to the ozone layer | Classification not possible | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
2016/9/2 Addition of Rationale for the classification |