GHS Classification Result

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GENERAL INFORMATION

Item Information
CAS number 366-18-7
Chemical name 2,2'-Bipyridyl
Substance ID 23A5061
Fiscal year of classification conducted FY2011
Classifier(s) (Ministries) Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
New/Revised New
Download in Excel format Excel file

REFERENCE INFORMATION

Item Information
Guidance used for classification (External link) Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010)
Environmental Hazards: UN GHS Document (4th revised edition)
Definitions / Abbreviations (Excel file) Definitions / Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS

Hazard class Classification Pictogram
(Code: symbol)
Signal word
Code
(Hazard statement)
Code
(Precautionary statement)
Rationale for the classification
1 Explosives Not applicable - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable - - - "Solids" according to GHS definition.
3 Aerosols Not applicable - - - Not an aerosol product.
4 Oxidizing gases Not applicable - - - "Solids" according to GHS definition.
5 Gases under pressure Not applicable - - - "Solids" according to GHS definition.
6 Flammable liquids Not applicable - - - "Solids" according to GHS definition.
7 Flammable solids Classification not possible - - - No data.
8 Self-reactive substances and mixtures Not applicable - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - "Solids" according to GHS definition.
10 Pyrophoric solids Classification not possible - - - No data.
11 Self-heating substances and mixtures Classification not possible - - - No established test method suitable for solid substances with a melting point of 140 degrees C or lower.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - "Solids" according to GHS definition.
14 Oxidizing solids Not applicable - - - An organic compound that does not contain oxygen, fluorine, or chlorine.
15 Organic peroxides Not applicable - - - An organic compound that does not contain -O-O- structure.
16 Corrosive to metals Classification not possible - - - No established test method suitable for solid substances.

HEALTH HAZARDS

Hazard class Classification Pictogram
(Code: symbol)
Signal word
Code
(Hazard statement)
Code
(Precautionary statement)
Rationale for the classification
1 Acute toxicity (Oral) Category 3

Danger
H301
P301+P310
P264
P270
P321
P330
P405
P501
All of 4 LD50 values for rats (107 mg/kg, 100 mg/kg, 256 mg/kg, 250 mg/kg) (IUCLID (2000)) correspond to Category 3.
1 Acute toxicity (Dermal) Category 3

Danger
H311
P302+P352
P280
P312
P322
P361
P363
P405
P501
It was classified in Category 3 that was the majority of possible categories to which 4 LD50 values for rats (>400 mg/kg, 250 to 600 mg/kg, 400 to 1000 mg/kg, 625 to 1250 mg/kg) (IUCLID (2000)) correspond.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - "Liquids" according to GHS definition.
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - No data.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - No data.
2 Skin corrosion/irritation Not classified - - - On the basis that 2 tests using rats reported "slightly irritating" (IUCLID (2000)), it was classified as "Not classified" in JIS classification (Category 3 in UN GHS classification).
3 Serious eye damage/eye irritation Category 2

Warning
H319
P305+P351+P338
P337+P313
P264
P280
A test using rabbits resulted in not irritating while another test reported moderately irritating with an unknown recovery period (IUCLID (2000)).
It was classified in Category 2 without sub-categorization by taking the information that pyridine and its derivatives cause local irritation on contact with the skin, mucous membrane and cornea (HSDB (2000)) into consideration and due to no description of the recovery period in the rabbit test.
4 Respiratory sensitization Classification not possible - - - No data.
4 Skin sensitization Classification not possible - - - Because a Draize test using guinea pigs, which reported not sensitizing (IUCLID (2000)), was not a test method agreed by OECD and from List 2 data, it was classified as "Classification not possible."
5 Germ cell mutagenicity Classification not possible - - - The classification is not possible due to no in vivo test data.
Besides, an Ames test as an in vitro test reported a negative or a positive. (IUCLID (2000))
6 Carcinogenicity Classification not possible - - - Lack of data.
Besides, IUCLID reported that 12 survived out of 20 mice and a mouse developed a parotid tumor by 40 times a week subcutaneous injections in 10 months. (IUCLID (2000))
7 Reproductive toxicity Classification not possible - - - Lack of data.
Besides, IUCLID reported that intraperitoneal administration of 60 to 75 mg/kg on gestation day 12.5 showed teratogenicity in limb bud development, and also reported that subcutaneous administration on gestation day 12.5 showed embryo absorption in 44% and external malformations in forelimb fingers in 88%. (IUCLID (2000))
8 Specific target organ toxicity - Single exposure Category 2 (nervous system)

Warning
H371
P309+P311
P260
P264
P270
P405
P501
From reports of behavioral suppression and loss of coordination in muscles after oral administration in rats (LD50: 100 mg/kg) (IUCLID (2000)) and tremor and slight ptosis after administration of 50 to 250 mg/kg (HSDB (2000)), it was classified in Category 2 (nervous system).
Besides, they correspond to Category 1 by judging from Guidance values, but it was classified in Category 2 in accordance with the Guidance because they are from List 2 and do not meet Decision Criteria 1b3) (OECD TG and GLP).
9 Specific target organ toxicity - Repeated exposure Category 2 (kidney)

Warning
H373
P260
P314
P501
A 90-day drinking water administration test (7, 13, 35.6 mg/kg/day) reported that some animals showed changes in the kidney that are calcium stone and nephrosclerosis and in some cases hypertrophy of Bowman's glomerular capsule and brown pigmentation in the renal tubular epithelium (IUCLID (2000)).
Due to data from List 2, it was classified in Category 2 (kidney), although it is unknown whether the effects were observed at a dose of the range of Category 1 in Guidance values.
Besides, no adverse effects were reported in a 28-day oral administration test in dogs at 10 to 40 mg/kg/day except occasional vomiting (IUCLID (2000)).
10 Aspiration hazard Classification not possible - - - No data.

ENVIRONMENTAL HAZARDS

Hazard class Classification Pictogram
(Code: symbol)
Signal word
Code
(Hazard statement)
Code
(Precautionary statement)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - No data.
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - No data.
12 Hazardous to the ozone layer Classification not possible - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTES:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
   and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.



Updated date:
2016/9/2 Addition of Rationale for the classification

List of GHS Classification Results