GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTES:
Updated date:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS number | 7397-62-8 |
| Chemical name | Butyl hydroxyacetate |
| Substance ID | 23A5041 |
| Fiscal year of classification conducted | FY2011 |
| Classifier(s) (Ministries) | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| New/Revised | New |
| Download in Excel format | Excel file |
| Item | Information |
|---|---|
| Guidance used for classification (External link) |
Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government （July, 2010）
Environmental Hazards: UN GHS Document （4th revised edition） |
| Definitions / Abbreviations (Excel file) | Definitions / Abbreviations |
| Model Label by MHLW (External link) | MHLW Website （in Japanese Only） |
| Model SDS by MHLW (External link) | MHLW Website （in Japanese Only） |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 3 | Aerosols | Not applicable | - | - | - | Not an aerosol product. |
| 4 | Oxidizing gases | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 5 | Gases under pressure | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 6 | Flammable liquids | Category 4 |
|
H227 |
P370+P378 P403+P235 P210 P280 P501 |
A flash point of 75 degrees C [closed cup] (Ullmanns (E) (6th, 2003)), which is > 60 degrees C and <= 93 degrees C, corresponds to Category 4. |
| 7 | Flammable solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not classified | - | - | - | It is conceivable that it does not ignite at normal temperatures from an ignition point of 404 degrees C (Ullmanns (E) (6th, 2003)). |
| 10 | Pyrophoric solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | No established test method suitable for liquid substances. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | An organic compound that contains oxygen which is not chemically bonded to elements other than carbon or hydrogen. |
| 14 | Oxidizing solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 15 | Organic peroxides | Not applicable | - | - | - | An organic compound that does not contain -O-O- structure. |
| 16 | Corrosive to metals | Classification not possible | - | - | - | No data. |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Not classified | - | - | - | All of 3 LD50 values for rats (4240 mg/kg, 4595 mg/kg, 4825 mg/kg) (IUCLID (2000)) correspond to "Not classified" in JIS classification (corresponding to Category 5 in UN GHS classification). |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | No data. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - |
Lack of data. The classification is not possible because the category cannot be determined from no mortality in rats in a exposure to the saturated vapour pressure concentration (7.10 mg/L) (converted to a 4-hour exposure equivalent value: 9.39 mg/L) for 7 hours. (IUCLID (2000)) |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | No data. |
| 2 | Skin corrosion/irritation | Not classified | - | - | - | On the basis of a "not irritating" result in a test using rabbits (OECD TG 404; GLP) (IUCLID (2000)), it was classified as "Not classified." |
| 3 | Serious eye damage/eye irritation | Category 2 |  |
H319 |
P305+P351+P338 P337+P313 P264 P280 |
On the basis of a "irritating" result in a test using rabbits (OECD TG 405; GLP) (IUCLID (2000)), it was classified in Category 2. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | No data. |
| 4 | Skin sensitization | Classification not possible | - | - | - | No data. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - |
The classification is not possible due to no in vivo test data. Besides, negatives in both an Ames test and a chromosomal aberration test using V79 cells are reported in in vitro tests. (IUCLID (2000)) |
| 6 | Carcinogenicity | Classification not possible | - | - | - | No data. |
| 7 | Reproductive toxicity | Category 2 |  |
H361 |
P308+P313 P201 P202 P281 P405 P501 |
In an oral administration test in pregnant rats during an organogenetic period (OECD TG 414; GLP), fetal toxicity such as embryo absorption and malformation in bones and viscera was observed at a high dose (1250 mg/kg), where parent animals showed toxicity including mortality (a number of deaths are unknown), clinical symptoms, and decreases in food consumption and weight gains. (IUCLID (2000)) A preliminary test showed toxicity to maternal animals and fetuses at a dose of 1000 mg/kg in addition to weak teratogenicity, and a final test showed 2 of cases of abnormalities in breast vertebra bone and costa, and a case of a diaphragmatic hernia at 1250 mg/kg. (IUCLID (2000)) From the above, it was classified in Category 2 because developmental effects such as teratogenicity were observed in fetuses at the dose where toxicity was shown in maternal animals. |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - | No data. |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - |
A 28-day repeated oral administration test in rats (OECD TG 407; GLP) reported an increased serum phosphate, decreased protein and red blood cell appearance in urinary sediment at the highest dose of 1000 mg/kg/day in both males and females, all of which are slight. (IUCLID (2000)) Because it was not clearly concluded from the information that it cannot be denied that the exposure to the test substance caused the result whose toxicological significance is unknown (IUCLID (2000)), it was classified as "classification not possible" due to lack of data. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | No data. |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Not classified | - | - | - | On the basis of 24-hour EC50 = 280 mg/L for crustacea (Daphnia magna) (IUCLID (2000)), it was classified as "Not classified." |
| 11 | Hazardous to the aquatic environment （Long-term） | Not classified | - | - | - |
Reliable chronic toxicity data were not obtained. From "Not classified" in acute toxicity and not water-insoluble (water solubility = 20000 mg/L, NITE (2012)), it was classified as "Not classified." |
| 12 | Hazardous to the ozone layer | Classification not possible | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
NOTES:
|
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Updated date:
|
2016/9/2 Addition of Rationale for the classification |