GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTES:
Updated date:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS number | 542-18-7 |
| Chemical name | Chlorocyclohexane |
| Substance ID | 23A5031 |
| Fiscal year of classification conducted | FY2011 |
| Classifier(s) (Ministries) | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| New/Revised | New |
| Download in Excel format | Excel file |
| Item | Information |
|---|---|
| Guidance used for classification (External link) |
Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government （July, 2010）
Environmental Hazards: UN GHS Document （4th revised edition） |
| Definitions / Abbreviations (Excel file) | Definitions / Abbreviations |
| Model Label by MHLW (External link) | MHLW Website （in Japanese Only） |
| Model SDS by MHLW (External link) | MHLW Website （in Japanese Only） |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 3 | Aerosols | Not applicable | - | - | - | Not an aerosol product. |
| 4 | Oxidizing gases | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 5 | Gases under pressure | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 6 | Flammable liquids | Category 3 |  |
H226 |
P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
A flash point of 32 degrees C [closed cup] (GESTIS (Access on Feb. 2011)), which is >= 23 degrees C and <= 60 degrees C, corresponds to Category 3. |
| 7 | Flammable solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not classified | - | - | - | It is conceivable that it does not ignite at normal temperatures from an ignition point of 290 degrees C (HSDB (2002)). |
| 10 | Pyrophoric solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | No established test method suitable for liquid substances. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | An organic compound that contains chlorine which is not chemically bonded to elements other than carbon. |
| 14 | Oxidizing solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 15 | Organic peroxides | Not applicable | - | - | - | An organic compound that does not contain -O-O- structure. |
| 16 | Corrosive to metals | Classification not possible | - | - | - | No data. |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Not classified | - | - | - | From no mortality at a dose of 2000 mg/kg and an LD50 value of > 2000 mg/kg for rats (Report on Toxicity Tests of Chemical Substances, MHLW (2007)), it was classified as "Not classified." |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | No data. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - |
Lack of data. Besides, an LC50 value of 40 mg/L/2h (30 mg/L/4h) in 2-hour exposure for rats (RTECS (2006)) is from List 3, and the details are unknown. The test condition is considered to be a vapour including mist because the LC50 value （40 mg/L） is not less than 90 % of the saturated vapour pressure concentration (43 mg/L). |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | No data. |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - |
No data. Besides, there is a description of cyclohexane that is "mildly irritating to human skin" (HSDB (2002)). |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | No data. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | No data. |
| 4 | Skin sensitization | Classification not possible | - | - | - | No data. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - |
Due to no in vivo test data, the classification is not possible. Besides, both an Ames test and a chromosomal aberration test with Chinese hamster lung cells reported negative results as in vitro tests (Report on Toxicity Tests of Chemical Substances, MHLW (2006)). |
| 6 | Carcinogenicity | Classification not possible | - | - | - | No data. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - |
A combined repeated dose toxicity study with reproduction/developmental toxicity screening test by oral administration to rats reported salivation and a decreased weight gain in parent animals as general toxicities at a high dose, but no changes in parameters such as sexual function, fertility, and survival and external surface of offspring, and no finding of evidence of reproduction toxicity related to this substance. (Report on Toxicity Tests of Chemical Substances, MHLW (2007)) However, due to lack of data, it was classified as "Classification not possible" in adverse effects on the development of the offspring including teratogenicity on fetal examination at term pregnancy. |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - |
An oral administration test to rats given 300 or 2000 mg/kg reported no mortality and no abnormalities in clinical signs and in necropsy except a decreased weight gain at 2000 mg/kg. (Report on Toxicity Tests of Chemical Substances, MHLW (2007)) But a blood biochemical test and a histological test were not conducted, therefore, due to lack of data it was classified as "Classification not possible." |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - |
A combined repeated dose toxicity study with reproduction/developmental toxicity screening test by oral administration to rats reported hyperplasia in bladder mucosal epithelium at doses of 60 mg/kg/day (converted to a 90-day equivalent value: 28 mg/kg/day) or higher, and salivation and a decreased weight gain, and histopathological signs such as increased hyaline droplet disposition in proximal tubular epithelium in kidney in males, hyperplasia in bladder mucosal epithelium in females, as well as an increased number of reticulocyte, decreased inorganic phosphorus, and increased kidney weight in males or females at a dose of 300 mg/kg/day respectively (converted to a 90-day equivalent value: 140 mg/kg/day). (Report on Toxicity Tests of Chemical Substances, MHLW (2007)) Out of the above results, the hyperplasia in bladder mucosal epithelium found in males at the dose of 60 mg/kg/day was not used as a basis for classification because they are all minimal and details are unknown, therefore, it was classified as "Classification not possible." Besides, all of the other effects were found in doses above the upper limit (100 mg/kg/day) of Guidance values. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | No data. |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 2 | - |
H401 |
P273 P501 |
On the basis of 48-hour EC50 = 4.018 mg/L for crustacea (Daphnia pulex) (AQUIRE, 2012), it was classified in Category 2. |
| 11 | Hazardous to the aquatic environment （Long-term） | Category 2 |  |
H411 |
P273 P391 P501 |
Reliable chronic toxicity data were not obtained. Due to lack of rapid degradability (hardly degradable, a degradation rate by BOD: 0 % (the existing chemicals survey program, 1977)) and acute toxicity Category 2, it was classified in Category 2. |
| 12 | Hazardous to the ozone layer | Classification not possible | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
NOTES:
|
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Updated date:
|
2016/8/17 Addition of Rationale for the classification |