Item | Information |
---|---|
CAS number | 371-40-4 |
Chemical name | 4-Fluoroaniline |
Substance ID | 23A5026 |
Fiscal year of classification conducted | FY2011 |
Classifier(s) (Ministries) | Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE) |
New/Revised | New |
Download in Excel format | Excel file |
Item | Information |
---|---|
Guidance used for classification (External link) |
Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010)
Environmental Hazards: UN GHS Document (4th revised edition) |
Definitions / Abbreviations (Excel file) | Definitions / Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Symbol Signal word |
Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable | - | - | - | There are no chemical groups associated with explosive properties present in the molecule. |
2 | Flammable gases (including chemically unstable gases) | Not applicable | - | - | - | "Liquids" according to GHS definition. |
3 | Aerosols | Not applicable | - | - | - | Not an aerosol product. |
4 | Oxidizing gases | Not applicable | - | - | - | "Liquids" according to GHS definition. |
5 | Gases under pressure | Not applicable | - | - | - | "Liquids" according to GHS definition. |
6 | Flammable liquids | Category 4 |
H227 |
P370+P378 P403+P235 P210 P280 P501 |
A flash point of 73 degrees C [closed-cup] (solvents pocket book (1994)) is > 60 degrees C and <= 93 degrees C, therefore it corresponds to Category 4. | |
7 | Flammable solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
8 | Self-reactive substances and mixtures | Not applicable | - | - | - | Containing neither chemical groups related to explosibility nor those related to self-reactivity. |
9 | Pyrophoric liquids | Classification not possible | - | - | - | No data. |
10 | Pyrophoric solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
11 | Self-heating substances and mixtures | Classification not possible | - | - | - | No established test method suitable for liquid substances. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable | - | - | - | An organic compound that contains fluorine which is not chemically bonded to elements other than carbon. |
14 | Oxidizing solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
15 | Organic peroxides | Not applicable | - | - | - | An organic compound that does not contain -O-O- structure. |
16 | Corrosive to metals | Classification not possible | - | - | - | No data. |
Hazard class | Classification |
Symbol Signal word |
Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
H302 |
P301+P312 P264 P270 P330 P501 |
On the basis of an LD50 value of 460 mg/kg for rats (HSDB (2003)), it was classified in Category 4. | |
1 | Acute toxicity (Dermal) | Classification not possible | - | - | - | An LDLo value of 1250 mg/kg bw for rats (RTECS (2006): original literature National Technical Information Service. OTS0543265) is reported, but the classification is not possible because the category cannot be determined only from this data. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable | - | - | - | "Liquids" according to GHS definition. |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible | - | - | - | No data. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible | - | - | - | No data. |
2 | Skin corrosion/irritation | Classification not possible | - | - | - |
Lack of data. Besides, a standard Draize test in which 0.2 mg was applied to rabbit skin for 24 hours reports that irritation is severe (RTECS (2006)), but it was classified as "Classification not possible" due to the data from List 3 and unknown details. |
3 | Serious eye damage/eye irritation | Category 2A |
H319 |
P305+P351+P338 P337+P313 P264 P280 |
On the basis of an MMAS (corresponding to AOI) of 69.8 in a test in which instillation of 0.1 ml of a 100 % solution of test substance was dosed into the conjunctival sac of six rabbits (OECD TG405, GLP), all of which showed corneal opacity, and conjunctivae redness and chemosis rating an average score of 1 or higher an hour after application, and five of them showed iritis after 3 days (ECETOC TR48 (1998)), it was classified in Category 2A. | |
4 | Respiratory sensitization | Classification not possible | - | - | - | No data. |
4 | Skin sensitization | Classification not possible | - | - | - | No data. |
5 | Germ cell mutagenicity | Classification not possible | - | - | - | No data. |
6 | Carcinogenicity | Classification not possible | - | - | - | No data. |
7 | Reproductive toxicity | Classification not possible | - | - | - | No data. |
8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - | "During short-term poisoning via the cutaneous route in rats, p-fluoroaniline causes a significant increase in methemoglobin level" is reported (HSDB (2003)), but the classification is not possible because exposure levels, exposure time, and results are unknown. |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | No data. |
10 | Aspiration hazard | Classification not possible | - | - | - | No data. |
Hazard class | Classification |
Symbol Signal word |
Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 3 | - |
H402 |
P273 P501 |
It was classified in Category 3 from 96-hour LC50 = 16.9 mg/L for fish (Pimephales promelas) (AQUIRE, 2012). |
11 | Hazardous to the aquatic environment (Long-term) | Category 3 | - |
H412 |
P273 P501 |
Reliable chronic toxicity data are not obtained. It was classified in Category 3 from lack of rapid degradability (BIOWIN) and acute toxicity Category 3. |
12 | Hazardous to the ozone layer | Classification not possible | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
2016/7/13 Addition of Rationale for the classification |