GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTES:
Updated date:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS number | 328-84-7 |
| Chemical name | 1,2-Dichloro-4-(trifluoromethyl)benzene |
| Substance ID | 23A5025 |
| Fiscal year of classification conducted | FY2011 |
| Classifier(s) (Ministries) | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| New/Revised | New |
| Download in Excel format | Excel file |
| Item | Information |
|---|---|
| Guidance used for classification (External link) |
Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government （July, 2010）
Environmental Hazards: UN GHS Document （4th revised edition） |
| Definitions / Abbreviations (Excel file) | Definitions / Abbreviations |
| Model Label by MHLW (External link) | MHLW Website （in Japanese Only） |
| Model SDS by MHLW (External link) | MHLW Website （in Japanese Only） |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 3 | Aerosols | Not applicable | - | - | - | Not an aerosol product. |
| 4 | Oxidizing gases | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 5 | Gases under pressure | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 6 | Flammable liquids | Category 4 |
H227 |
P370+P378 P403+P235 P210 P280 P501 |
A flash point of 72 degrees C [closed-cup] (IUCLID (2000)) , which is > 60 degrees C and <= 93 degrees C, corresponds to Category 4. | |
| 7 | Flammable solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not classified | - | - | - | It is conceivable that it does not ignite at normal temperatures from an ignition temperature of > 600 degrees C (IUCLID (2000)). |
| 10 | Pyrophoric solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | No established test method suitable for liquid substances. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | An organic compound contains fluorine and chlorine, and these elements are not chemically bonded to elements other than carbon. |
| 14 | Oxidizing solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 15 | Organic peroxides | Not applicable | - | - | - | An organic compound that does not contain -O-O- structure. |
| 16 | Corrosive to metals | Classification not possible | - | - | - | No data. |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Not classified | - | - | - | It was classified as "Not classified" in JIS classification (corresponding to Category 5 in UN GHS classification) from the majority of 4 LD50 values for rats (1150 mg/kg, 3288 mg/kg (male), 2896 mg/kg (female), 2956 mg/kg) (US EPA/HPV (2008), corresponding to List 1). One data corresponds to Category 4, and 3 data correspond to "Not classified" in JIS classification. |
| 1 | Acute toxicity （Dermal） | Not classified | - | - | - | Both 2 data, an LD50 value of > 7390 mg/kg for rats (USEPA/HPV (2008)) and an LD50 value of > 5000 mg/kg for rabbits (USEPA/HPV (2008)), correspond to "Not classified." |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - |
The classification is not possible because the category cannot be determined only from an LC50 value of > 15.86 mg/L/4h (> 1871 ppm/4h) for rats (US EPA/HPV (2008)). Besides, a reference value of gasses as a vapour with hardly included mist was applied because the test concentration (1871 ppm) is lower than 90 % of the saturated vapour pressure concentration (3105 ppm). |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | No data. |
| 2 | Skin corrosion/irritation | Category 2 |  |
H315 |
P302+P352 P332+P313 P264 P280 P321 P362 |
Because a PII (primary irritation index) of 2.75 in a test of an occlusive application of 0.5 mL of an undiluted test substance to rabbit skins and a PII of 4.3 in another test of an occlusive application of 0.5 mL of the undiluted test substance to rabbit skin for 24 hours were both assessed as moderately irritating (US EPA/HPV (2008)), it was classified in Category 2. |
| 3 | Serious eye damage/eye irritation | Not classified | - | - | - |
A Draize test applied 0.1 mL of an undiluted test substance to rabbit eyes was assessed as not irritating (US EPA/HPV (2008)). Another test applied 0.1 mL of an undiluted test substance to a rabbit conjunctival sac was assessed as slightly irritating, and the only effect which was score 2 in the conjunctiva in 1 of 6 animals reversed within 72 hours (US EPA/HPV (2008)). From the above results, it was classified as "Not classified." |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | No data. |
| 4 | Skin sensitization | Classification not possible | - | - | - |
A skin sensitization test using guinea pigs (Buehler test) concluded from 0 % (0/9) positive rate in both topical (dermal) and systemic (intradermal) challenges in the challenge phase after induction that this substance was not sensitizing in guinea pigs (US EPA/HPV (2008)). However, because the test was not accordance with GLP and there is no other information, it was classified as "Classification not possible." |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - |
The classification is not possible due to no in vivo test data. Besides, an Ames test in an in vitro test reported a negative result (Mutagenicity test data, Industrial Safety and Health Law, Supplement 3 (2005), (US EPA/HPV (2008))). |
| 6 | Carcinogenicity | Classification not possible | - | - | - | No data. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - |
A reproduction test in which rats were orally administrated from prior to mating through gestation and delivery period until weaning of F1 litters was conducted. Judging from effects on weight changes in liver and kidney in parent animals without comments on reproductive toxicity, there were no adverse effects on sexual function and fertility (US EPA/HPV (2008)). However, because effects on development of the offspring including teratogenicity are unknown due to no fetal examination data at the end of gestation, it was classified as "Classification not possible" due to lack of data. |
| 8 | Specific target organ toxicity - Single exposure | Category 3 （Respiratory tract irritation） | |
H335 |
P304+P340 P403+P233 P261 P271 P312 P405 P501 |
Rats showed dry rales, mucoid or red nasal discharges, labored breathing during the 14-day observation period as well as a lung discoloration in necropsy, but no mortality after inhalation exposures (vapour) at 8.59 mg/L or 15.86 mg/L. (US EPA/HPV (2008)) From the above result, it was classified in Category 3 (Respiratory tract irritation). |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - |
Rats did not show dose-related changes other than increased liver weights in a 14-day oral administration test of 7.5 to 120 mg/kg/day (converted to a 90-day equivalent values:1.2 to 18.7 mg/kg/day). (US EPA/HPV (2008)) A 90-day oral administration test (5 to 45 mg/kg/day) from prior to mating male and female rats until weaning of F1 litters reported changes in liver and kidney weights in parents, but no other adverse effects, and NOAEL of 45 mg/kg/day (US EPA/HPV (2008)). The above both tests did not report any adverse effects related to administration of this substance, but effects near the upper limit of guidance values were unknown because the both doses of testing were within the guidance values. Therefore, it was classified as "Classification not possible" due to lack of data. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | No data. |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | Due to lack of data, the classification is not possible. |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | Due to lack of data, the classification is not possible. |
| 12 | Hazardous to the ozone layer | Classification not possible | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
NOTES:
|
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Updated date:
|
2016/10/13 Addition of Rationale for the classification |