Item | Information |
---|---|
CAS number | 110-01-0 |
Chemical name | Tetrahydrothiophene |
Substance ID | 23A5019 |
Fiscal year of classification conducted | FY2011 |
Classifier(s) (Ministries) | Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE) |
New/Revised | New |
Download in Excel format | Excel file |
Item | Information |
---|---|
Guidance used for classification (External link) |
Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010)
Environmental Hazards: UN GHS Document (4th revised edition) |
Definitions / Abbreviations (Excel file) | Definitions / Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Symbol Signal word |
Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable | - | - | - | There are no chemical groups associated with explosive properties present in the molecule. |
2 | Flammable gases (including chemically unstable gases) | Not applicable | - | - | - | "Liquids" according to GHS definition. |
3 | Aerosols | Not applicable | - | - | - | Not an aerosol product. |
4 | Oxidizing gases | Not applicable | - | - | - | "Liquids" according to GHS definition. |
5 | Gases under pressure | Not applicable | - | - | - | "Liquids" according to GHS definition. |
6 | Flammable liquids | Category 2 |
H225 |
P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
A flash point of 13 degrees C [closed-cup] (IMDG (2008)) is < 23 degrees C, and an initial boiling point of 119 to 121 degrees C is > 35 degrees C, therefore, it corresponds to Category 2. Besides, it is classified in 3PGII in UNRTDG (UN2412). |
|
7 | Flammable solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
8 | Self-reactive substances and mixtures | Not applicable | - | - | - | Containing neither chemical groups related to explosibility nor those related to self-reactivity. |
9 | Pyrophoric liquids | Not classified | - | - | - | It is conceivable that it does not ignite at normal temperatures from an auto-ignition temperature: 200 degrees C (ICSC (1998)). |
10 | Pyrophoric solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
11 | Self-heating substances and mixtures | Classification not possible | - | - | - | No established test method suitable for liquid substances. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable | - | - | - | An organic compound that does not contain oxygen, fluorine, or chlorine. |
14 | Oxidizing solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
15 | Organic peroxides | Not applicable | - | - | - | An organic compound that does not contain -O-O- structure. |
16 | Corrosive to metals | Classification not possible | - | - | - | No data. |
Hazard class | Classification |
Symbol Signal word |
Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
H302 |
P301+P312 P264 P270 P330 P501 |
On the basis of an LD50 value of 1850 mg/kg for rats (FIFRA, GLP compliance) (IUCLID (2000)), it was classified in Category 4. | |
1 | Acute toxicity (Dermal) | Not classified | - | - | - | From an LD50 value of >2000 mg/kg and no death in the administration of 2000 mg/kg to rabbits (FIFRA, GLP compliance) (IUCLID (2000)), it was classified as "Not classified." |
1 | Acute toxicity (Inhalation: Gases) | Not applicable | - | - | - | "Liquids" according to GHS definition. |
1 | Acute toxicity (Inhalation: Vapours) | Category 4 |
H332 |
P304+P340 P261 P271 P312 |
On the basis of an LC50 value of 6270 ppm/4h for rats (Federal Register 44 (145), GLP compliance) (IUCLID (2000)), it was classified in Category 4. Besides, a reference value of gasses was applied because the LC50 value (6270 ppm) is lower than 90 % of the saturated vapour pressure concentration (23692 ppm). |
|
1 | Acute toxicity (Inhalation: Dusts and mists) | Not classified | - | - | - |
On the basis of an LC50 value of 155 mg/L/1h = 38.75 mg/L/4h for rats (IUCLID (2000)), it was classified as "Not classified." Besides, it was considered to be a test by mist because the toxicity value (155 mg/L) was higher than the saturated vapour pressure concentration (85 mg/L). |
2 | Skin corrosion/irritation | Classification not possible | - | - | - |
A test using rabbits (FHSA compliance) evaluates this substance as not a skin irritant (HSDB (2003), ITC/USEPA; Information Review #307 (1982)). On the other hand, it is classified in Xi; R38, Skin Irrit.2 in EU (EC-JRC (ESIS) (Access on Jan. 2011)), which is a conflicting result. It was classified as "Classification not possible" due to no other information. |
3 | Serious eye damage/eye irritation | Classification not possible | - | - | - |
A test using rabbits (FHSA compliance) evaluates this substance as not an eye irritant because it does not induce local inflammatory reaction (HSDB (2003), ITC/USEPA; Information Review #307 (1982)), On the other hand, it is classified in Xi; R36, Eye Irrit.2 in EU (EC-JRC (ESIS) (Access on Jan. 2011)), which is a conflicting result. It was classified as "Classification not possible" due to no other information. |
4 | Respiratory sensitization | Classification not possible | - | - | - | No data. |
4 | Skin sensitization | Classification not possible | - | - | - | No data. |
5 | Germ cell mutagenicity | Classification not possible | - | - | - |
The classification is not possible due to no in vivo test data. Besides, negatives were reported in all of an Ames test (OECD TG471, GLP compliance), an HGPRT test using CHO cells (OECD TG476, GLP compliance), and a chromosomal aberration test using human lymphocyte as in vitro tests (JECFA No.1146 (2008)). |
6 | Carcinogenicity | Classification not possible | - | - | - | No data. |
7 | Reproductive toxicity | Classification not possible | - | - | - | An inhalation exposure test to pregnant rats during an organogenetic period (GLP compliance) reports no teratogenicity and no effect on a fetus (IUCLID (2000)), but effects on sexual function and fertility are not able to be judged due to no data, therefore, it was classified as "Classification not possible." |
8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - |
Lack of data. Besides, information that workers at a factory producing this substance complained of headache palpitations, giddiness, general feeling of being unwell after a short exposure (HSDB (2003)), the necropsy after deaths in oral administration to rats found changes in lung, stomach, and intestines in animal tests (IUCLID (2000)), and inhalation exposure to rats caused slight lacrimation, peripheral vasodilation, and ataxia was reported, but further details of which are unknown. |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - |
A 90-day vapour inhalation test (OECD, GLP compliance), in which rats were exposed to concentrations up to maximal 1500 ppm/6h (5.41 mg/L/6h) reported only a slight irritant, but no serious adverse effect, and NOAEL of 50 ppm (0.18 mg/L/6h) (IUCLID (2000)) without further details. The classification is not possible due to lack of data as a basis for classification. |
10 | Aspiration hazard | Classification not possible | - | - | - | No data. |
Hazard class | Classification |
Symbol Signal word |
Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Classification not possible | - | - | - | No data. |
11 | Hazardous to the aquatic environment (Long-term) | Classification not possible | - | - | - | No data. |
12 | Hazardous to the ozone layer | Classification not possible | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
2016/7/13 Addition of Rationale for the classification |