| Item | Information |
|---|---|
| CAS number | 99-62-7 |
| Chemical name | 1,3-Diisopropylbenzene |
| Substance ID | 23A5012 |
| Fiscal year of classification conducted | FY2011 |
| Classifier(s) (Ministries) | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| New/Revised | New |
| Download in Excel format | Excel file |
| Item | Information |
|---|---|
| Guidance used for classification (External link) |
Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government （July, 2010）
Environmental Hazards: UN GHS Document （4th revised edition） |
| Definitions / Abbreviations (Excel file) | Definitions / Abbreviations |
| Model Label by MHLW (External link) | MHLW Website （in Japanese Only） |
| Model SDS by MHLW (External link) | MHLW Website （in Japanese Only） |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 3 | Aerosols | Not applicable | - | - | - | Not an aerosol product. |
| 4 | Oxidizing gases | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 5 | Gases under pressure | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 6 | Flammable liquids | Category 4 |
H227 |
P370+P378 P403+P235 P210 P280 P501 |
A flash point of > 60 degrees C and <= 93 degrees C in a prescribed closed-cup test method may be judged from 76 degrees C [unkown] (Lange (16th, 2005)) in an unknown test method, therefore, it corresponds to Category 4. | |
| 7 | Flammable solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not classified | - | - | - | It is conceivable that it does not ignite at normal temperatures from an ignition temperature of 449 degrees C (GESTIS (Access on Dec. 2010)). |
| 10 | Pyrophoric solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | No established test method suitable for liquid substances. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | An organic compound that does not contain oxygen, fluorine, or chlorine. |
| 14 | Oxidizing solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 15 | Organic peroxides | Not applicable | - | - | - | An organic compound that does not contain -O-O- structure. |
| 16 | Corrosive to metals | Classification not possible | - | - | - | No data. |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Not classified | - | - | - | All of three LD50 values for rats (7400 mg/kg, > 5000 mg/kg (both SIDS (Access on Dec. 2010)), > 5000 mg/kg (US EPA/HPV (2003)) correspond to "Not Classified." |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | No data. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | No data. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | No data. |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | No data. |
| 3 | Serious eye damage/eye irritation | Not classified | - | - | - | From MMAS (an irritation index equivalent to AOI) of 2/110 in a test applied 0.1mL of an undiluted test substance to 6 rabbits (OECD TG 405; GLP) in which no effects on cornea and iris but mild redness and chemosis of the conjunctiva completely reversed in 2 to 7 days after application were observed in all animals (ECETOC TR 48 (1998)), it was classified as "Not classified." |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | No data. |
| 4 | Skin sensitization | Classification not possible | - | - | - | No data. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - |
No data. Besides, as in vitro tests on isomer mixture of unknown ratio, negative results were reported in both an Ames test and a chromosomal aberration test with CHL/IU cells (Report on Toxicity Tests of Chemical Substances, MHLW (Access on Dec. 2010)). |
| 6 | Carcinogenicity | Classification not possible | - | - | - | No data. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - |
Lack of data. Besides, decreased fertility and miscarriages in rats or mice, and disturbance of the sex cycle, depressed pregnancy ability, and a decreased number of pups in rats by inhalation exposure were reported. (SIDS (Access on Dec. 2010)). But these data were not used as a basis for classification because SIDS commented that the reliability of these Russian reports from the 1970s was uncertain due to no details obtainable (SIDS (Access on Dec. 2010)). On the other hand, a preliminary reproductive toxicity screening test (OECD TG 421; GLP) in which rats were orally dosed an isomer mixture reported adverse effects on neither male and female parents nor offspring were observed. (Report on Toxicity Tests of Chemical Substances, MHLW (Access on Dec. 2010)) |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - |
In an acute toxicity test in which five males and females rats in each dose were orally administrated at 1250, 2500, and 5000 mg/kg, this substance is described as practically non-toxic (US EPA/HPV (2003)) resulting from no death, no behavioral or gross pathological changes, and weight gain in all animals. Therefore it corresponds to "Not classified" in an oral route, but it was classified as "Classification not possible" in specific target organ toxicity (single exposure) due to no data of other routes. |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - |
A gastric irritation and an increase in liver weights were the main effects in a 29-day oral administration test (OECD TG 407; GLP) in rats dosed at 100, 300, and 1000 mg/kg. (US EPA/HPV (2003)) Hyperkeratosis and edema in the non-glandular region were not used as a basis for the classification because those findings were not systemic effects but were direct irritant responses. An increase in liver weight was also not used as a basis for the classification because it was described as a result of adaptive induction of metabolic enzymes subsequent by repeated exposure to higher doses, but not as an adverse effect. (US EPA/HPV (2003)) Therefore, it corresponds to "Not classified" in an oral route resulting from no adverse effect observed at the maximal dose of 1000 mg/kg/day (a 90-day conversion: 322 mg/kg/day) above a range of the upper limit of Guidance values. But it was classified as "Classification not possible" in specific target organ toxicity (repeated exposure) due to no other route data. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | No data. |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | No data. |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | No data. |
| 12 | Hazardous to the ozone layer | Classification not possible | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
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* Hazard statement or Precautionary statement will show when hovering the mouse over a code of Hazard statement or Precautionary statement. Hazard statement and Precautionary statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
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2017/1/30 Addition of Rationale for the classification |