GHS Classification Result

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GENERAL INFORMATION

Item Information
CAS number 98-13-5
Chemical name Trichlorophenylsilane
Substance ID 23A5011
Fiscal year of classification conducted FY2011
Classifier(s) (Ministries) Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
New/Revised New
Download in Excel format Excel file

REFERENCE INFORMATION

Item Information
Guidance used for classification (External link) Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government （July, 2010）
Environmental Hazards: UN GHS Document （4th revised edition）
Definitions / Abbreviations (Excel file) Definitions / Abbreviations
Model Label by MHLW (External link) MHLW Website （in Japanese Only）
Model SDS by MHLW (External link) MHLW Website （in Japanese Only）
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS

Hazard class Classification Symbol
Signal word 		Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases （including chemically unstable gases） Not applicable - - - "Liquids" according to GHS definition.
3 Aerosols Not applicable - - - Not an aerosol product.
4 Oxidizing gases Not applicable - - - "Liquids" according to GHS definition.
5 Gases under pressure Not applicable - - - "Liquids" according to GHS definition.
6 Flammable liquids Category 4
Warning
 H227
 P370+P378
P403+P235
P210
P280
P501
 A flash point of 86 degrees C [closed cup] (GESTIS (Access on Dec. 2010)) is > 60 degrees C and <= 93 degrees C, therefore, it corresponds to Category 4.
7 Flammable solids Not applicable - - - "Liquids" according to GHS definition.
8 Self-reactive substances and mixtures Not applicable - - - Containing neither chemical groups related to explosibility nor those related to self-reactivity.
9 Pyrophoric liquids Not classified - - - It is conceivable that it does not ignite at normal temperatures because an ignition temperature is not lower than 400 degrees C (HSDB (2010)).
10 Pyrophoric solids Not applicable - - - "Liquids" according to GHS definition.
11 Self-heating substances and mixtures Classification not possible - - - No established test method suitable for liquid substances.
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - There is information that a compound that contains a semimetal (Si) reacts vigorously with water and produces hydrogen chloride (IMDG (2008)), therefore, it was classified as "Not classified" because flammable gasses are not emitted.
13 Oxidizing liquids Classification not possible - - - An organic compound that contains chlorine which is chemically bonded to an element (Si) other than carbon, but there are no data.
14 Oxidizing solids Not applicable - - - "Liquids" according to GHS definition.
15 Organic peroxides Not applicable - - - An organic compound that does not contain -O-O- structure.
16 Corrosive to metals Classification not possible - - - There is information that it is not suitable for a container due to highly corrosive to most metals (Hommel (1996)), but the classification was not possible due to no prescribed data.

HEALTH HAZARDS

Hazard class Classification Symbol
Signal word 		Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - On the basis of an LD50 value of 2390 mg/kg for rats (HSDB (2010)), it was classified as "Not classified" in JIS classification (corresponding to Category 5 in UN GHS classification).
1 Acute toxicity （Dermal） Category 4

Warning
 H312
 P302+P352
P280
P312
P322
P363
P501
 On the basis of an LD50 value of 1166 mg/kg for rabbits (HSDB (2010)), it was classified in Category 4.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - "Liquids" according to GHS definition.
1 Acute toxicity （Inhalation: Vapours） Category 1

Danger
 H330
 P304+P340
P403+P233
P260
P271
P284
P310
P320
P405
P501
 On the basis of an LC50 value of 0.33 mg/L/2h for mice (converted to a 4-hour equivalent: 0.23 mg/L (26.6 ppm)) (HSDB (2010)), it was classified in Category 1.
Besides, a reference value of gasses was applied because the LC50 value (0.33 mg/L = 38.2 ppm) is lower than 90 % of the saturated vapour pressure concentration (561 ppm).
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - No data.
2 Skin corrosion/irritation Category 1

Danger
 H314
 P301+P330+P331
P303+P361+P353
P305+P351+P338
P304+P340
P260
P264
P280
P310
P321
P363
P405
P501
 It was classified in Category 1 base on a result as "highly corrosive" in a rabbit test (IUCLID (2000)) and a result indicating "corrosion" in another rabbit test (HSDB (2000)).
3 Serious eye damage/eye irritation Category 1

Danger
 H318
 P305+P351+P338
P280
P310
 It was classified in Category 1 because a test using rabbits was rated 9 on a scale of 1 to 10 according to a degree of injury which was paid particular attention to the condition of corneas (HSDB (2010)), and another test using rabbits resulted in "highly corrosive" (IUCLID (2000)).
4 Respiratory sensitization Classification not possible - - - No data.
4 Skin sensitization Classification not possible - - - No data.
5 Germ cell mutagenicity Classification not possible - - - No data.
6 Carcinogenicity Classification not possible - - - No data.
7 Reproductive toxicity Classification not possible - - - No data.
8 Specific target organ toxicity - Single exposure Category 2 (respiratory system)

Warning
 H371
 P309+P311
P260
P264
P270
P405
P501
 It is reported that mice exposed to low vapor concentrations showed breathlessness, cyanosis, and mucosal irritation as well as agitated motor activity and convulsions (HSDB (2010)), and the animals which died in the post-observation period showed edema in the brain and lung as well as degenerative effects in the liver, and distinct lung damage (HSDB (2010), GESTIS (Access on Dec. 2010)).
An LC50 value of 0.23 mg/L/4h corresponds to Category 1 in accordance with the Guidance values, but it was classified in Category 2 (respiratory system) because data were from List 2 and that does not meet Decision Criteria 1b3).
Besides, there are warnings that "breathing phenyl trichlorosilane can irritate the lungs causing coughing and/or shortness of breath," and "higher exposures can cause a build-up of fluid in the lungs (pulmonary edema), a medical emergency, with severe shortness of breath" (HSFS (2000)).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - No data.
10 Aspiration hazard Classification not possible - - - No data.

ENVIRONMENTAL HAZARDS

Hazard class Classification Symbol
Signal word 		Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - No data.
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - No data.
12 Hazardous to the ozone layer Classification not possible - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTES:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.



Updated date:
2016/6/29 Addition of Rationale for the classification

List of GHS Classification Results