GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTES:
Updated date:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS number | 78-81-9 |
| Chemical name | Isobutylamine |
| Substance ID | 23A5008 |
| Fiscal year of classification conducted | FY2011 |
| Classifier(s) (Ministries) | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| New/Revised | New |
| Download in Excel format | Excel file |
| Item | Information |
|---|---|
| Guidance used for classification (External link) |
Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government （July, 2010）
Environmental Hazards: UN GHS Document （4th revised edition） |
| Definitions / Abbreviations (Excel file) | Definitions / Abbreviations |
| Model Label by MHLW (External link) | MHLW Website （in Japanese Only） |
| Model SDS by MHLW (External link) | MHLW Website （in Japanese Only） |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Symbol Signal word |
Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 3 | Aerosols | Not applicable | - | - | - | Not an aerosol product. |
| 4 | Oxidizing gases | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 5 | Gases under pressure | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 6 | Flammable liquids | Category 2 |  |
H225 |
P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
A flash point of -9 degrees C [closed cup] (ICSC (2005)) is < 23 degrees C, and an initial boiling point of 68 degrees C is > 35 degrees C, therefore, it is classified in Category 2. |
| 7 | Flammable solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | Containing neither chemical groups related to explosibility nor those related to self-reactivity. |
| 9 | Pyrophoric liquids | Not classified | - | - | - | It is conceivable that it does not ignite at normal temperatures from an ignition point of 378 degrees C (Merck (14th, 2006)). |
| 10 | Pyrophoric solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | No established test method suitable for liquid substances. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | An organic compound that does not contain fluorine, chlorine, or oxygen. |
| 14 | Oxidizing solids | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 15 | Organic peroxides | Not applicable | - | - | - | An organic compound that does not contain -O-O- structure. |
| 16 | Corrosive to metals | Not classified | - | - | - | From information that stainless steel, steel, and aluminum are durable as a container (Hommel (1996)), it was classified as "Not classified." |
| Hazard class | Classification |
Symbol Signal word |
Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 3 |  |
H301 |
P301+P310 P264 P270 P321 P330 P405 P501 |
On the basis of an LD50 value of 228 mg/kg bw for rats (PATTY (5th, 2001)), it was classified in Category 3. |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | No data. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | "Liquids" according to GHS definition. |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | No data. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | No data. |
| 2 | Skin corrosion/irritation | Category 1 |  |
H314 |
P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501 |
It was classified in Category 1 because it was judged that exposure causes irreversible damage to skin from a description as "skin contact can result in erythema and blistering" (PATTY (5th, 2001)), and a description as "a powerful irritant to skin, eyes and mucous membrane" accompanied by pain, redness, and burns to skin (HSDB (2008)). Besides, there is information that the substance is corrosive to the eyes, skin and respiratory tract as effects of short-time exposures (ICSC (J) (2005)). |
| 3 | Serious eye damage/eye irritation | Category 1 | |
H318 |
P305+P351+P338 P280 P310 |
On the basis of a description as "a powerful irritant to skin, eyes and mucous membrane" (HSDB (2008)) and being classified as corrosive substance in skin corrosion/irritation, it was classified in Category 1. Besides, there is information that if it gets in eyes that can lead to blindness (GESTIS (Access on Jan. 2011)). |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | No data. |
| 4 | Skin sensitization | Classification not possible | - | - | - | No data. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - |
The classification is not possible due to no in vivo test data. Besides, a negative in an Ames test as an in vitro test was reported (NTP DB (1982)). |
| 6 | Carcinogenicity | Classification not possible | - | - | - | No data. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | No data. |
| 8 | Specific target organ toxicity - Single exposure | Category 3 （Respiratory tract irritation） |  |
H335 |
P304+P340 P403+P233 P261 P271 P312 P405 P501 |
On the basis of descriptions of symptoms caused by inhalation in a human such as dryness of a nose and a throat, burning sensation, cough, shortness of breath, and labored breathing (PATTY (5th, 2001), HSDB (2008)), it was classified in Category 3 (respiratory tract irritation). |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | No data. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | No data. |
| Hazard class | Classification |
Symbol Signal word |
Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | No data. |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | No data. |
| 12 | Hazardous to the ozone layer | Classification not possible | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
NOTES:
|
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Updated date:
|
2016/6/29 Addition of Rationale for the classification |