GHS Classification Result

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GENERAL INFORMATION

Item Information
CAS number 124-19-6
Chemical name 1-Nonanal
Substance ID 23A5004
Fiscal year of classification conducted FY2011
Classifier(s) (Ministries) Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
New/Revised New
Download in Excel format Excel file

REFERENCE INFORMATION

Item Information
Guidance used for classification (External link) Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010)
Environmental Hazards: UN GHS Document (4th revised edition)
Definitions / Abbreviations (Excel file) Definitions / Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS

Hazard class Classification Pictogram
(Code: symbol)
Signal word
Code
(Hazard statement)
Code
(Precautionary statement)
Rationale for the classification
1 Explosives Not applicable - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable - - - "Liquids" according to GHS definition.
3 Aerosols Not applicable - - - Not an aerosol product.
4 Oxidizing gases Not applicable - - - "Liquids" according to GHS definition.
5 Gases under pressure Not applicable - - - "Liquids" according to GHS definition.
6 Flammable liquids Category 4
No pictogram

Warning
H227
P370+P378
P403+P235
P210
P280
P501
Because a flash point of 75 degrees C [closed cup] (GESTIS (Access on Nov. 2010)) is > 60 degrees C and < 93 degrees C, it was classified in Category 4.
7 Flammable solids Not applicable - - - "Liquids" according to GHS definition.
8 Self-reactive substances and mixtures Not applicable - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - It was classified as "Not classified" because it is conceivable that it does not ignite at normal temperatures from an ignition temperature of 200 degrees C (GESTIS (Access on Nov. 2010)).
10 Pyrophoric solids Not applicable - - - "Liquids" according to GHS definition.
11 Self-heating substances and mixtures Classification not possible - - - No established test method suitable for liquid substances.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - An organic compound that contains oxygen which is not chemically bonded to elements other than carbon or hydrogen.
14 Oxidizing solids Not applicable - - - "Liquids" according to GHS definition.
15 Organic peroxides Not applicable - - - An organic compound that does not contain -O-O- structure.
16 Corrosive to metals Classification not possible - - - No data.

HEALTH HAZARDS

Hazard class Classification Pictogram
(Code: symbol)
Signal word
Code
(Hazard statement)
Code
(Precautionary statement)
Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - From LD50 values of > 5000 mL/kg (> 4125 mg/kg) (JECFA FAS14 (1979)) and > 5000 mg/kg (JECFA 906 (1998) FAS 40) for rats, it was classified as "Not classified."
1 Acute toxicity (Dermal) Not classified - - - From LD50 values of > 5000 mL/kg (> 4125 mg/kg) (JECFA FAS14 (1979)) and > 5000 mg/kg (HSDB (2005)) for rabbits, it was classified as "Not classified."
1 Acute toxicity (Inhalation: Gases) Not applicable - - - "Liquids" according to GHS definition.
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - No data.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - No data.
2 Skin corrosion/irritation Category 2

Warning
H315
P302+P352
P332+P313
P264
P280
P321
P362
From a primary irritation index (PII) of 3.46/8 in a test using 4 rabbits (OECD TG404, GLP compliance) in which erythema and edema were observed in all animals throughout the 7-day observation period after administration (ECETOCTR63 (1995)), it was classified in Category 2.
Besides, severe edema and burns were observed at application sites at a dose of 5000 mg/kg in an acute dermal toxicity test in rabbits. (HSDB (2005))
3 Serious eye damage/eye irritation Classification not possible - - - No data.
4 Respiratory sensitization Classification not possible - - - No data.
4 Skin sensitization Classification not possible - - - No data.
5 Germ cell mutagenicity Classification not possible - - - The classification is not possible due to no in vivo test data.
Besides, as in vitro tests, negatives were reported in an Ames test (NTP DB (1982), JECFA FAS48 (2002)), a micronucleus test and a chromosomal aberration test both using rat hepatocytes (JECFA FAS48 (2002)).
And a positive was reported in a gene mutation test using Chinese hamster lung cells (V79) (JECFA FAS40 (1998)).
6 Carcinogenicity Classification not possible - - - No data.
7 Reproductive toxicity Classification not possible - - - No data.
8 Specific target organ toxicity - Single exposure Category 3 (Narcotic effects)

Warning
H336
P304+P340
P403+P233
P261
P271
P312
P405
P501
On the basis that rats showed no death and completely recovered from observed signs of dullness and lethargy 24 to 48 hours after oral administration of 5000 mg/kg (HSDB (2005)), it was classified in Category 3 (narcotic effects).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - Lack of data.
Besides, no adverse effect observed was reported as a result of 12-week diet administration in rats using a mixture of six aliphatic aldehydes including this substance (estimated dose of the substance: 29 mg/kg/day). (JECFA FAS14 (1979)).
In addition, 2-week dermal administration in rabbits at 500 mg/kg/day (converted to a 90-day equivalent: 76.9 mg/kg/day) reported no dose-related changes except decreases in food consumption and body weights, local effects such as erythema, necrosis, and exfoliation by irritation at the skin of application sites. (HSDB (2005))
But the classification is not possible because the all above doses were within a range of Guidance values.
10 Aspiration hazard Classification not possible - - - No data.

ENVIRONMENTAL HAZARDS

Hazard class Classification Pictogram
(Code: symbol)
Signal word
Code
(Hazard statement)
Code
(Precautionary statement)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 2
No pictogram

No signal word
H401
P273
P501
From 96-hour LC50 = 5.52 mg/L for fish (Pimephales promelas) (HSDB, 2005), it was classified in Category 2.
11 Hazardous to the aquatic environment (Long-term) Not classified - - - Reliable chronic toxicity data were not obtained.
Despite rapid degradability (degradation rate by TOC: 96% (Results of the Existing Chemicals Survey, 2002)) and acute toxicity Category 2, on the basis of low bioaccumulation estimate (logKow = 3.27 (PHYSPROP Database, 2012)), it was classified as "Not classified."
12 Hazardous to the ozone layer Classification not possible - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTES:
* Hazard statement or Precautionary statement will show when hovering the mouse over a code of Hazard statement or Precautionary statement.
   Hazard statement and Precautionary statement are also provided in the Excel file.
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
   and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.



Updated date:
  2017/1/30 Addition of Rationale for the classification

List of GHS Classification Results