GHS Classification Result

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GENERAL INFORMATION

Item Information
CAS number 97-74-5
Chemical name Tetramethylthiuram monosulfide
Substance ID 23A5002
Fiscal year of classification conducted FY2011
Classifier(s) (Ministries) Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
New/Revised New
Download in Excel format Excel file

REFERENCE INFORMATION

Item Information
Guidance used for classification (External link) Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010)
Environmental Hazards: UN GHS Document (4th revised edition)
Definitions / Abbreviations (Excel file) Definitions / Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS

Hazard class Classification Pictogram
(Code: symbol)
Signal word
Code
(Hazard statement)
Code
(Precautionary statement)
Rationale for the classification
1 Explosives Not applicable - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable - - - "Solids" according to GHS definition.
3 Aerosols Not applicable - - - Not an aerosol product.
4 Oxidizing gases Not applicable - - - "Solids" according to GHS definition.
5 Gases under pressure Not applicable - - - "Solids" according to GHS definition.
6 Flammable liquids Not applicable - - - "Solids" according to GHS definition.
7 Flammable solids Classification not possible - - - The Classification is not possible because there are no data based on a prescribed test though there is information that it is a "Combustible solid" (GESTIS (Access on Nov. 2010)).
8 Self-reactive substances and mixtures Not applicable - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - "Solids" according to GHS definition.
10 Pyrophoric solids Not classified - - - It was classified as "Not classified" because it can be judged not to ignite at normal temperatures from an ignition point of 315 degrees C. (NITE Chemical Risk Information Platform (Access on Nov. 2010)) (KANTO CHEMICAL CO., INC. reagent catalog)
11 Self-heating substances and mixtures Classification not possible - - - No established test method suitable for solid substances with a melting point of 140 degrees C or lower.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - "Solids" according to GHS definition.
14 Oxidizing solids Not applicable - - - An organic compound that does not contain oxygen, fluorine, or chlorine.
15 Organic peroxides Not applicable - - - An organic compound that does not contain -O-O- structure.
16 Corrosive to metals Classification not possible - - - No established test method suitable for solid substances.

HEALTH HAZARDS

Hazard class Classification Pictogram
(Code: symbol)
Signal word
Code
(Hazard statement)
Code
(Precautionary statement)
Rationale for the classification
1 Acute toxicity (Oral) Category 4

Warning
H302
P301+P312
P264
P270
P330
P501
All reported four data (1320 mg/kg, 900 mg/kg, 620-869 mg/kg, and 918-1300 mg/kg) (IUCLID (2000)) on an LD50 value for rats correspond to Category 4.
1 Acute toxicity (Dermal) Classification not possible - - - Lack of data.
Besides, a test using one male or one female rabbit per one dose in which no death was observed up to 2000 mg/kg (IUCLID (2000)) was not used as a basis for the classification, because not appropriate was commented on the test.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - "Solids" according to GHS definition.
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - No data.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - No data.
2 Skin corrosion/irritation Not classified - - - From an irritation score of 0.7/8.0 as a result of a test applied to rabbit skin for 24 hours which reported "slightly irritating" (IUCLID (2000)), it was classified as "Not classified."
3 Serious eye damage/eye irritation Not classified - - - Slight to moderate conjunctival redness and lots of exudates observed in a test applied 0.1 g to rabbit eyes recovered within 72 hours.
From "slightly irritating" reported as a result and an irritation score of 4/110 (equivalent to AOI) (IUCLID (2000)), it was classified as "Not classified."
4 Respiratory sensitization Classification not possible - - - No data.
4 Skin sensitization Category 1

Warning
H317
P302+P352
P333+P313
P261
P272
P280
P321
P363
P501
A repeated insult patch test of 50 human volunteers concluded that this substance was a sensitizing substance (IUCLID (2000)).
And there are several reports that a patch test of ambulatory patients having a skin disease and workers of factories such as rubber industry having dermatitis indicates a positive reaction to this substance (IUCLID (2000), HSDB (2003)).
Furthermore, it is listed as a sensitizing substance in Contact Dermatitis (Frosch) (4th, 2006).
Therefore, it was classified in Category 1.
5 Germ cell mutagenicity Not classified - - - On the basis of a negative result in a chromosome aberration test by oral administration to rats (an in vivo somatic cell mutagenicity test: GLP compliance), it was classified as "Not classified."
Besides, a micronucleus test by intraperitoneal administration to Chinese hamsters (an in vivo somatic cell mutagenicity test), which reported statistically significant increase of polychromatophilic erythrocyte with micronucleus (IUCLID (2000)), was not used as a basis for the classification due to a slight increase, a few animals, and low test evaluation (IUCLID (2000)).
In addition, both of an Ames test and a gene mutation test using Chinese hamster V79 cells and mouse lymphoma L5178Y cells reported negatives as in vitro tests (IUCLID (2000)).
6 Carcinogenicity Classification not possible - - - A 19-month oral administration test using two strains mice did not show carcinogenicity. (IUCLID (2000))
But the result was from only one animal species (mice) and the test was not based on test guidelines.
Therefore, it was classified as "Classification not possible" due to lack of data.
7 Reproductive toxicity Classification not possible - - - No teratogenicity observed up to a dose of 100 mg/kg bw/day in a developmental toxicity test by subcutaneous administration in an organogenetic period of two strains mice (IUCLID (2000)) was data of subcutaneous administration and unknown details.
In addition, there are no data on effects on a sexual function and fertility.
Therefore, it was classified as "Classification not possible" due to lack of data.
8 Specific target organ toxicity - Single exposure Classification not possible - - - In a single oral administration test using rats, toxic symptoms of anorexia, hypoactivity, a collapse, and on an autopsy, pneumonemia, discoloration of a liver, and gastrointestinal inflammation were observed, and an LD50 value of 1320 mg/kg was reported. (IUCLID (2000))
But a dosage of manifestation is unknown and specification of target organs is difficult.
Because the data are from List 2, it was classified as "Classification not possible" due to lack of data.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - Significant decreases of a red blood count and an amount of hemoglobin, and as a slight change of organs, mild widespread swelling in liver cells and renal uriniferous tubule epithelium by 4-week repeated oral administration of 26 mg/kg/day to female rats (90-day correction: 8mg/kg/day) were reported (IUCLID (2000)).
The dose is equivalent to Category 1 in guidance values.
But the test was only female and one dose. And there were no other supportive data.
Therefore, it was classified as "Classification not possible."
10 Aspiration hazard Classification not possible - - - No data.

ENVIRONMENTAL HAZARDS

Hazard class Classification Pictogram
(Code: symbol)
Signal word
Code
(Hazard statement)
Code
(Precautionary statement)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1

Warning
H400
P273
P391
P501
It was classified in Category 1 from 96-hour EC50 = 1 mg/L for algae (Chlorella pyrenoidosa) (AQUIRE, 2012).
11 Hazardous to the aquatic environment (Long-term) Category 1

Warning
H410
P273
P391
P501
If chronic toxicity data are used, then it is classified in Category 1 because it is non-rapidly degradable (BIOWIN) and 60-day LOEC = 0.01 mg/L for fish (Oncorhynchus mykiss) (AQUIRE, 2012).
If acute toxicity data are used for trophic levels for which chronic toxicity data are not available, then it is classified in Category 1 because it is non-rapidly degradable (BIOWIN) and 96-hour EC50 = 1 mg/L for algae (Chlorella pyrenoidosa) (AQUIRE, 2012).
From the above results, it was classified in Category 1.
12 Hazardous to the ozone layer Classification not possible - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTES:
* Hazard statement or Precautionary statement will show when hovering the mouse over a code of Hazard statement or Precautionary statement.
   Hazard statement and Precautionary statement are also provided in the Excel file.
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government,
   and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.



Updated date:
  2017/1/30 Addition of Rationale for the classification

List of GHS Classification Results