GHS Classification Result

日本語で表示

GENERAL INFORMATION

Item Information
CAS number 102-08-9
Chemical name N,N'-Diphenylthiourea
Substance ID 23A5001
Fiscal year of classification conducted FY2011
Classifier(s) (Ministries) Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
New/Revised New
Download in Excel format Excel file

REFERENCE INFORMATION

Item Information
Guidance used for classification (External link) Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010)
Environmental Hazards: UN GHS Document (4th revised edition)
Definitions / Abbreviations (Excel file) Definitions / Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS

Hazard class Classification Symbol
Signal word
Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable - - - "Solids" according to GHS definition.
3 Aerosols Not applicable - - - Not an aerosol product.
4 Oxidizing gases Not applicable - - - "Solids" according to GHS definition.
5 Gases under pressure Not applicable - - - "Solids" according to GHS definition.
6 Flammable liquids Not applicable - - - "Solids" according to GHS definition.
7 Flammable solids Classification not possible - - - The Classification is not possible because there are no data based on a prescribed test though there is information that it is “COMBUSTIBLE” (HSDB (2003)).
8 Self-reactive substances and mixtures Not applicable - - - Containing neither chemical groups related to explosibility nor those related to self-reactivity.
9 Pyrophoric liquids Not applicable - - - "Solids" according to GHS definition.
10 Pyrophoric solids Classification not possible - - - The Classification is not possible because there are no data based on a prescribed test though there is information that it is “COMBUSTIBLE” (HSDB (2003)).
11 Self-heating substances and mixtures Classification not possible - - - No data.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - "Solids" according to GHS definition.
14 Oxidizing solids Not applicable - - - An organic compound that does not contain oxygen, fluorine, or chlorine.
15 Organic peroxides Not applicable - - - An organic compound that does not contain -O-O- structure.
16 Corrosive to metals Classification not possible - - - No established test method suitable for solid substances.

HEALTH HAZARDS

Hazard class Classification Symbol
Signal word
Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 3

Danger
H301 P301+P310
P264
P270
P321
P330
P405
P501
On the basis of an LD50 value of 70 mg/kg bw for rats (RTECS (1997): original literature; Archives of Toxicology 54, 275, 1983), it was classified in Category 3.
1 Acute toxicity (Dermal) Classification not possible - - - No data.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - "Solids" according to GHS definition.
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - No data.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - No data.
2 Skin corrosion/irritation Classification not possible - - - No data.
3 Serious eye damage/eye irritation Classification not possible - - - No data.
4 Respiratory sensitization Classification not possible - - - No data.
4 Skin sensitization Category 1

Warning
H317 P302+P352
P333+P313
P261
P272
P280
P321
P363
P501
It was classified in Category 1 due to the conclusion that "Diphenylthiourea is a human and animal skin sensitizer (limited data)" (ECETOC 77 (1999)) and being listed as a sensitizing substance in Contact Dermatitis (Frosch) (4th, 2006).
5 Germ cell mutagenicity Classification not possible - - - The Classification is not possible because there are no in vivo test data.
Besides, a "Negative" or "Equivocal" result in an Ames test was reported as an in vitro test (NTP DB (Access on Nov. 2010)).
6 Carcinogenicity Classification not possible - - - No data.
7 Reproductive toxicity Classification not possible - - - No data.
8 Specific target organ toxicity - Single exposure Classification not possible - - - No data.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - No data.
10 Aspiration hazard Classification not possible - - - No data.

ENVIRONMENTAL HAZARDS

Hazard class Classification Symbol
Signal word
Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 3 - H402
P273
P501
It was classified in Category 3 from 96-hour LC50 = 18.9mg/L for fish (Pimephales promelas) (AQUIRE, 2012).
11 Hazardous to the aquatic environment (Long-term) Category 3 - H412 P273
P501
Reliable chronic toxicity data were not obtained.
It was classified in Category 3 due to lack of rapid degradability (BIOWIN), and acute toxicity Category 3.
12 Hazardous to the ozone layer Classification not possible - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTES:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.



Updated date:
2016/6/15 Correction of Rationale for the classification (Germ cell mutagenicity)
2016/4/26 Addition of Rationale for the classification

List of GHS Classification Results