GHS Classification Result （Revision of the past classification result）
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：2-Butene, 1,4-dichloro-
CAS：764-41-0
Result：
| ID: | 22B4529 |
| Classifier: | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| Year Classified: | FY2010 |
| Reference Manual: | GHS Classification Guidance by the Japanese Government （July, 2010） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecule. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 6 | Flammable liquids | Category 3 |
|
Warning | H226: Flammable liquid and vapour |
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P233: Keep container tightly closed. P240: Ground/bond container and receiving equipment. P241: Use explosion-proof electrical/ventilating/lighting/.../equipment. P242: Use only non-sparking tools. P243: Take precautionary measures against static discharge. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ... |
Since its flash point 59 degC (closed-cup) (Gangolli (2nd, 1999)) is >= 23 degC and <= 60 degC, the substance corresponds to Category 3. |
| 7 | Flammable solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 8 | Self-reactive substances and mixtures | Classification not possible | - | - | - | - | Classification is not possible since no data are available though it contains chemical groups (unsaturated bonds) associated with self-reactive properties in the molecule. |
| 9 | Pyrophoric liquids | Classification not possible | - | - | - | - | No data available. |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to liquid substances are not available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | The substance is an organic compound containing chlorine (but not fluorine or oxygen) which is chemically bonded only to carbon or hydrogen. |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no bivalent -O-O- structure in the molecule |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 3 |
|
Danger | H301: Toxic if swallowed |
P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ... |
The rat LD50 values of 89 mg/kg bw (ACGIH (2001) and SIDS (2006)), 220 mg/kg bw (SIDS (2006)) and 120 - 300 mg/kg bw (SIDS (2006)) were reported and all of them corresponded to Category 3. Therefore, the substance was classified as Category 3. |
| 1 | Acute toxicity （Dermal） | Category 3 |
|
Danger | H311: Toxic in contact with skin |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P280: Wear protective gloves/protective clothing/eye protection/face protection. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P322: Specific treatment （see ... on this label）. P361: Remove/Take off immediately all contaminated clothing. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the rabbit LD50 value of 735 mg/kg bw (ACGIH (2001), SIDS (2006)), the substance was classified into Category 3. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Category 1 |
|
Danger | H330: Fatal if inhaled |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P284: Wear respiratory protection. P310: Immediately call a POISON CENTER or doctor/physician. P320: Specific treatment is urgent （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
The rat LC50 values of 0.45 mg/L/4hrs (86 ppm/4hrs) (SIDS (2006) and ACGIH (2001)) and 1.35 mg/L/4hrs (264 ppm/4hrs) (SIDS (2006)) were reported, and they correspond to Category 1 and Category 2, respectively. Selecting the category of greater hazard, the substance was classified as Category 1. The test concentration (86 ppm) was lower than 90% of the saturated vapor pressure concentration (3950 ppm), the test substance was treated as "vapor hardly coexisting mists" and the criterion values for gas were adopted. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available. |
| 2 | Skin corrosion/irritation | Category 1 |
|
Danger | H314: Causes severe skin burns and eye damage |
P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ... |
The treatment of the forearms of human volunteers for 0.5 to 1 hour with the undiluted substance caused marked erythema, edema, and development of blisters (SIDS (2006)). Liquid and vapors of the substance caused extremely corrosive to human skin (SIDS (2006)). Based on the information, the substance was classified as Category 1. |
| 3 | Serious eye damage/eye irritation | Category 1 |
|
Danger | H318: Causes serious eye damage |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. |
The substance was classified as Category 1 based on the document that application of one drop of the substance to rabbit eye led to severe burns of the cornea and permanent damage, the substance was judged as severe eye irritant (ACGIH (2001)). As relevant information, it was reported that liquid and vapors of the substance were extremely irritating to human eyes (SIDS (2006)). |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available. |
| 5 | Germ cell mutagenicity | Category 2 |
|
Warning | H341: Suspected of causing genetic defects |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Positive results were reported in the chromosome aberration test using bone marrow of rats by the inhalation exposure (in vivo mutagenicity test in somatic cells) (SIDS (2006)). Positive results were also indicated in the dominant lethal test using rats by oral or inhaled administration for 2.5 months (in vivo mutagenicity test in germ cells) (SIDS (2006)), but information on the testing method and detail of results were unknown. From the results mentioned above, effects of this substance on the somatic cells were clear, however, findings of effects on germ cells were insufficient. Therefore, the substance was classified as Category 2 based on the positive results of the chromosome aberration test of rats (in vivo mutagenicity test in somatic cells) described above. As relevant information, negative results were reported in the micronucleus test using rats by 2-week inhalation exposure (in vivo mutagenicity test in somatic cells) (OECD TG474, GLP-compliance) (SIDS (2006)). As for in vitro studies, positive results were reported in the Ames test and the gene mutation test using CHO cells (SIDS (2006), NTP DB (Access on Jan. 2011)). |
| 6 | Carcinogenicity | Category 1B |
|
Danger | H350: May cause cancer |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
The substance was classified as Category 1B based on "A2" judgment in the carcinogenicity criteria of the ACGIH (ACGIH-TLV (2006)) and "Category 2" in the EU (EU Annex 1 (2006)). As relevant information, the substance was classified as "Group 3" by the IARC assessment (IARC 71 (1994)). |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | In the developmental toxicity study in rats by inhalation exposure during the organogenetic period, no adverse effects were observed in reproductive index and development of the fetus in the high dose group that maternal body weight gain was significantly reduced. Thus, this material was judged to show neither the embryotoxic nor teratogenic potential (SIDS (2006)). On the other hand, it was reported that in the oral or inhalation studies in male rats for 2.5 months, in addition to abnormalities and necrosis in the cells of the spermatogenic epithelium were observed, increased preimplantation mortality of embryos after mating of treated males with untreated females (SIDS (2006)). However, it was reported that detail of the test method and result were not mentioned and the documentation was insufficient for assessment (SIDS (2006)). Therefore, since data on sexual functions and fertility were insufficient, and no data on exposure for females were available, the substance was classified as "Classification not possible". As relevant information, in another study, an increase in the incidence of postimplantation death was reported for rats that inhaled during the pregnancy, however, this data was concluded as insufficient for assessment (SIDS (2006)). |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (respiratory system, nervous system, systemic toxicity), Category 3 (narcotic effects) |
|
Danger Warning |
H370: Causes damage to organs (respiratory system, nervous system, systemic toxicity) H336: May cause drowsiness or dizziness (narcotic effects) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. |
In addition to occurrence of deaths, toxic symptoms containing spasm, inappetence and weakness were observed in the acute oral toxicity study in rats at the dose levels of 119 and 297 mg/kg. Moreover, clinical symptoms consisting of spasm with gasping and flaccid paralysis were observed in the acute vapor inhalation toxicity study in rats at the concentration of 47 mg/L (SIDS (2006)). Since the exposure amounts in either study were equivalent to Category 1 of the guidance values, the substance was classified as Category 1 (nervous system). Further, in the acute inhalation (as vapors) study in rats, occurrence of deaths, irregular respiration, lacrimation and salivation were observed at the concentrations 0.364 mg/L and above, and lesions and hemorrhages in the lungs and trachitis were noted in histopathological examinations (SIDS (2006)). In another acute inhalation (as vapors) study in rats, marked reduction in respiratory rate was observed at 0. 15 mg/L and above, and the damage of epithelium of bronchus was found at 2.13 mg/L/30 min (0.74 mg/L/4hrs) and above, respectively (SIDS (2006)). All of the effective doses corresponded to Category 1 of the guidance values, thus the substance was classified as Category 1 (respiratory system). Furthermore, in the inhalation studies described above, cell degenerations in the liver, spleen, thymus and lymph nodes, or renal damage were observed concurrently (SIDS (2006)). Based on the information, since the effects by administration of the substance might extend systemically to the multiple organs, the substance was classified as Category 1 (systemic toxicity). Additionally, it was reported, in the human case, that depression of central nervous might occur by the exposure via oral and inhalation at low concentration, and coma might occur rapidly in inhalation at high concentrations (HSDB (2006)). Thus, the substance was classified as Category 3 (narcotic effect). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (respiratory system) |
|
Danger | H372: Cause damage to organs through prolonged or repeated exposure (respiratory system) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
In the 4-week inhalation study in rats exposed by vapors, concentration dependent effects on respiratory epithelium were observed, and inflammations and focal ulcerations were noted in mucous membranes of the nasal to respiratory tract and bronchi in the treatment groups at 8 and 12 ppm/6hrs (converted dose level as that of 90-day study: 0.014 and 0.021 mg/L/6hrs) (SIDS (2006), ACGIH (2001)). In another rat inhalation study exposed by vapors for up to 19 months, hyperplasia of basal cell in the nasal cavity and focal atrophy in the mucous membranes of the nasal cavities were observed in the group at 1 ppm/6hrs (0.0052 mg/L/6hrs) after 3 months of exposure (SIDS (2006)). As mentioned above, since the dose levels were all within Category 1 of the guidance values, the substance was classified as Category 1 (respiratory organ system). Besides, the effects on the liver were reported in the 26-week oral study in rats (RTECS (2009)). However, this information was not adopted as the evidence to classify due to information from the "List 3" information source designated in the GHS classification guidance for the Japanese government with its details unspecified. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 1 |
|
Warning | H400: Very toxic to aquatic life |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Classified into Category 1 from its 96h-LC50 = 0.42 mg/L for fish (Lepomis macrochirus) (IUCLID, 2000). |
| 11 | Hazardous to the aquatic environment （Long-term） | Category 1 |
|
Warning | H410: Very toxic to aquatic life with long lasting effects |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Classified into Category 1 since its acute toxicity is Category 1 and it is estimated not to be rapidly degradable (28 days degradation rate tested by OECD TG305D = 0% (IUCLID, 2000)). |
| 12 | Hazardous to the ozone layer | Classification not possible | - | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |