GHS Classification Result （Revision of the past classification result）

Chemical Name：1,2-Oxathiolane 2,2-dioxide
CAS：1120-71-4

Result：
ID: 22B4528
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2010
Reference Manual: GHS Classification Guidance by the Japanese Government （July, 2010）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available.
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to solid (melting point <= 140 degC) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - Classification is not possible since no data are available though the substance contains oxygen atoms (but not fluorine or chlorine) bonded to sulfur atoms.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Two LD50 values for rats of 157 and 350 mg/kg (DFGMAK-Doc vol. 4 (1992)) were reported, and they correspond to Category 3 and Category 4, respectively. Selecting the category of greater hazard, the substance was classified into Category 3.
1 Acute toxicity （Dermal） Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the rabbit LD50 value of 660 mg/kg (DFGMAK-Doc vol.4 (1992)), the substance was classified into Category 3.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - The substance caused skin irritation to animal skin and caused contact dermatitis to human skin (DFGOT, vol.4, (1992)). But, because the reference of the information was "personal communication" and sufficient data were not available, the substance was classified as "Classification was possible". As relevant information, mild irritation was reported in the rabbit test (RTECS (2009)).
3 Serious eye damage/eye irritation Classification not possible - - - - The classification was not possible due to lack of data. As for the information from the "List 3" information source designated in the GHS classification guidance for the Japanese government, there are the description that the substance caused slight irritation to human eye (ICSC(J)(2004)), and eye irritant (HSFS (2000), SITTIG, 4th (2002)).
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		The substance was classified as Category 2 based on the positive results in the micronucleus test using peripheral blood obtained from mice intraperitoneally administered (in vivo mutagenicity test in somatic cells) (Mutat. Res., 389, 3-122 (1997)). As relevant information, positive results were reported in DNA break test (alkaline elution assay) using brain cells of rats (in vivo genotoxicity test in somatic cells) (IARC 71 (1999)). As for in vitro studies, positive results in the Ames test and the chromosome aberration test using CHL cells were reported (DFGMAK-Doc. 4 (1992)).
6 Carcinogenicity Category 1B Danger H350: May cause cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the carcinogenicity criteria of "2B" in the IARC (IARC 71 (1999)), "Group 2B" in Japan Society For Occupational Health (JSOH) (Recommendations for allowable concentrations (2010)) and "A3" in the ACGIH (ACGIH-TLV (2010)), the classification was equivalent to Category 2. However, the local or systemic tumors were induced in various organs with high frequency by the oral exposure for approximately six months to one year in animal studies and the carcinogenicity was observed in rats 78 weeks after single dermal administration (IARC 71 (1999)). This substance has been reported as a potent carcinogen in animal studies (DFGMAK-Doc.4 (1992)). Therefore, the substance was classified as Category 1B. As relevant information on humans, cerebral glioblastomas, intestinal malignant tumors, hematopoietic/lymphoid malignant tumors and renal cell carcinomas were reported in the follow-up study of 20 workers (the total number was unknown) who were exposed to this substance in 1950 - 1970 in chemical plant in Germany, and the organs and sites of these tumors had sufficiently coincided with those in animals (Toxicology Letters 151, 251-254 (2004)).
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - It was reported that acute intoxication by exposure to the substance was characterized by early apathy, progressive dyspnea, bloody diarrhea, and occasionally also tremor and spasm. Depending on the dose levels, death occurred between 6 hours and several days after exposure to the substance. Pathological examination revealed hemorrhagic pulmonary edema, severe intestinal bleeding and marked cerebral edema. It was also reported that the substance was highly cytotoxic and could cause necrosis (DFGMAK-Doc.4 (1992)). However, because whether the objects for exposure were humans or animals was unknown, and no detailed descriptions of the conditions such as exposure route and dose levels were given, the substance was classified as "Classification not possible" due to lack of sufficient data.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - No data available.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - No data available.
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - No data available.
12 Hazardous to the ozone layer Classification not possible - - - - This substance is not listed in Annexes to the Montreal Protocol.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information