GHS Classification Result （Revision of the past classification result）
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Magnesium nitrate
CAS：10377-60-3
Result：
| ID: | 22B4525 |
| Classifier: | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| Year Classified: | FY2010 |
| Reference Manual: | GHS Classification Guidance by the Japanese Government （July, 2010） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not classified | - | - | - | - | The substance does not fall under Explosives since it is classified into Division 5.1, PG III in UNRTDG (UN1474) though it contains chemical groups (-NO3) associated with explosive properties. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Solid at room temperature (Sax (11th, 2004)) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Solid at room temperature (Sax (11th, 2004)) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Solid at room temperature (Sax (11th, 2004)) |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Solid at room temperature (Sax (11th, 2004)) |
| 7 | Flammable solids | Not classified | - | - | - | - | Not combustible (IUCLID (2000)) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | The substance is classified as "Not applicable" since it is classified into Division 5.1, PG III in UNRTDG (UN1474) though it contains chemical groups associated with explosive properties. |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid at room temperature (Sax (11th, 2004)) |
| 10 | Pyrophoric solids | Not classified | - | - | - | - | Not combustible (IUCLID (2000)) |
| 11 | Self-heating substances and mixtures | Not classified | - | - | - | - | Not combustible (IUCLID (2000)) |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified | - | - | - | - | Although the substance contains a metal (Mg), the water solubility data 71.2 g/100 g H2O at 25 degC (HSDB (2003)) is obtained and it is judged not to react vigorously with water. |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid at room temperature (Sax (11th, 2004)) |
| 14 | Oxidizing solids | Category 3 |
|
Warning | H272: May intensity fire; oxidizer |
P370+P378: In case of fire: Use ... for extinction. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P220: Keep/Store away from clothing/.../combustible materials. P221: Take any precaution to avoid mixing with combustibles/... P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ... |
The substance is classified into Division 5.1, PG III (UN1474) in UNRTDG. |
| 15 | Organic peroxides | Not applicable | - | - | - | - | The substance is not an organic compound. |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to solid substances are not available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Not classified | - | - | - | - | Based on the rat LD50 of 5440 mg/kg bw (IUCLID (2000)), the substance was classified as "Not classified". |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Solid at room temperature (Sax, 11th (2004)). |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available. |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | The classification was not possible due to lack of data. In the standard Draize test using rabbit, application of 500 mg of magnesium nitrate hexahydrate for 24 hours caused a mild reaction (RTECS (1998)). And it was reported that the substance was severe irritant to human skin (HSDB (2003)). However, no description of details was available. |
| 3 | Serious eye damage/eye irritation | Category 2 |
|
Warning | H319: Causes serious eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. |
The substance was classified as Category 2 based on the information that in the standard Draize test using rabbit, application of 500 mg of magnesium nitrate hexahydrate caused a mild reaction (IUCLID (2000), complemented with RTECS (1998)). |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | No data available. |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | The classification was not possible due to no data available. As relevant information, the IARC (IARC Vol.94 (2010)) described that the evidence of carcinogenicity in humans for nitrates in drinking water was uncertain. And also, it was evaluated the carcinogenicity as "Group 2A" under the conditions that nitrates or nitrites could be nitrosated in vivo after oral ingestion. The comprehensive evaluation of the IARC described additionally as follows: There is an active endogenous nitrogen cycle in humans that involves nitrates and nitrites, which are interconvertible in vivo. Nitrosating agents that arise from nitrites under acidic gastric conditions react readily with compounds which are easily nitrosated, especially secondary amines and amides, to generate N-nitroso compounds. These nitrosating conditions are enhanced following ingestion of additional nitrates, nitrites or nitroso compounds. Some of the N-nitroso compounds have the possibility to form known carcinogens in humans under these conditions. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | No data available. |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (blood) |
|
Danger | H370: Causes damage to organs (blood) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
There were no reports on human health for the substance concerned. With regard to information for general water-soluble nitrates, there was report stating that 15 soldiers who ingested sodium nitrate by mistake instead of table salts became methemoglobinemia. Of them, the 13 that ingested about 15 g died, while the two that ingested 5 g survived (ECETOC TR 27 (1988)). Based on the information, the substance was classified as Category 1 (blood). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (blood) |
|
Danger | H372: Cause damage to organs through prolonged or repeated exposure (blood) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
With regard to chronic toxicity of general water-soluble nitrates, there were numerous reports of increased methemoglobin concentrations observed in the infants who ingested meal or water containing nitrates, and case reports of methemoglobinemia observed in the patients administered sodium nitrate or ammonium nitrate as a diuretic agent or in the patients treated with ammonium nitrate as an urolithiasis-preventive agent were presented (ECETOC TR27 (1988)). Based on the information, the substance was classified as Category 1 (blood). Besides, the effects on the heart, etc. were reported as ones of nitrates, but these were considered to be secondary effect by methemoglobinemia-induced hypoxia (EHC 5 (1978)). |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | - | No data available. |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | - | No data available. |
| 12 | Hazardous to the ozone layer | Classification not possible | - | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |